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What is the chemical structure of 5- (imidazo [1,2-a] pyridin-6-yl) -6-methyl-2-oxo-1, 2-dihydropyridine-3-carbonitrile
This is related to the chemical structure of 5- (imidazolo [1,2 - a] pyridine-6-yl) -6-methyl-2-oxo-1,2-dihydropyridine-3-formonitrile. The structure of this compound is cleverly connected by several parts.
Looking at its structure, the core is the ring system of dihydropyridine, and there is an oxo group at the 2 position. This oxo group has a great influence on the chemical properties and reactivity of the compound, giving it a specific electron cloud distribution and reaction check point. The 6-position is methyl, and the introduction of methyl may change the steric hindrance and electronic effect of the molecule, which affects its physical and chemical properties.
Furthermore, the 3-position is connected with a formonitrile group, and the nitrile group is a strong electron-absorbing group, which can make the molecule have specific polarity and reactivity, and plays a key role in many chemical reactions.
Especially important, the 5-position is connected with imidazolo [1,2-a] pyridine-6-yl, which also adds unique properties to the compound. The imidazolopyridine ring system has a special electronic structure and aromaticity, which interacts with the dihydropyridine ring to make the structure and properties of the whole molecule more complex and unique. This structure endows the compound with potential biological activity, optical properties or other special properties, which may have important applications in the fields of medicinal chemistry, materials science and other fields.
5- (imidazo [1,2-a] pyridin-6-yl) -6-methyl-2-oxo-1, what are the physical properties of 2-dihydropyridine-3-carbonitrile
5- (imidazolo [1,2-a] pyridine-6-yl) -6-methyl-2-oxo-1,2-dihydropyridine-3-formonitrile, this is an organic compound. It has specific physical properties.
Looking at its appearance, it is usually in a solid state, mostly white or off-white powder, and has a fine texture. As for the melting point, it has been accurately determined to be roughly within a certain range. This melting point characteristic is crucial for the identification and purification of this compound. Due to different purity substances, the melting point may vary slightly.
Solubility is also one of the important physical properties. In common organic solvents, such as ethanol and dichloromethane, it exhibits a certain solubility. In ethanol, with the increase of temperature, the solubility increases. Due to the increase in temperature, the thermal motion of the molecule intensifies, and the force between the solvent and the solute molecules changes. In water, the solubility of the compound is very small. Due to the large proportion of hydrophobic parts in the molecular structure, it is difficult to form an effective force with water molecules.
In addition, the density of the compound is also an inherent physical property. The density data measured under specific conditions is of great significance for the study of its dispersion and mixing in different media. At the same time, its stability in the solid state is quite good, and under conventional environmental conditions, it can maintain its own structure and properties unchanged for a long time. However, under extreme conditions such as high temperature, strong acid, and strong alkali, or chemical reactions occur, resulting in changes in structure and properties.
What is the common synthesis method of 5- (imidazo [1,2-a] pyridin-6-yl) -6-methyl-2-oxo-1, 2-dihydropyridine-3-carbonitrile
5- (imidazolo [1,2-a] pyridine-6-yl) -6-methyl-2-oxo-1,2-dihydropyridine-3-formonitrile is an organic compound, and its common synthesis method is as follows.
First take imidazolo [1,2-a] pyridine derivative as the starting material, this derivative can be obtained by the condensation reaction of pyridine and imidazole. Place pyridine and imidazole in a suitable organic solvent, such as toluene or dichloromethane, add an appropriate amount of condensation agent, such as triethylamine or potassium carbonate, and stir the reaction at a certain temperature. After the reaction is completed, the pure imidazolo [1,2-a] pyridine derivative can be obtained by separation and purification methods, such as column chromatography.
The obtained imidazolo [1,2-a] pyridine derivative is then reacted with the 6-methyl-2-oxo-1,2-dihydropyridine-3-formonitrile precursor. The precursor is generally prepared by cyanidation of the corresponding pyridinone derivative. The pyridinone derivative is dissolved in a suitable solvent, such as DMF or DMSO, and a cyanidation agent, such as potassium cyanide or sodium cyanide, is added. The cyanidation reaction is carried out at appropriate temperature and reaction conditions.
After the preparation of 6-methyl-2-oxo-1, 2-dihydropyridine-3-formonitrile precursor is completed, mix with imidazolo [1, 2-a] pyridine derivative, add suitable catalyst, such as palladium catalyst or copper catalyst, and react under a certain temperature and inert gas protection. The reaction process needs to be closely monitored, and the reaction process can be tracked by thin layer chromatography. After the
reaction, the product undergoes a series of post-processing steps, including extraction, washing, drying, and recrystallization, to obtain high-purity 5- (imidazolo [1,2-a] pyridine-6-yl) -6-methyl-2-oxo-1,2-dihydropyridine-3-formonitrile.
The entire synthesis process requires attention to the precise control of reaction conditions, the choice of solvent, and the amount of reactants and catalysts, so as to effectively improve the yield and purity of the product.
5- (imidazo [1,2-a] pyridin-6-yl) -6-methyl-2-oxo-1, in which areas 2-dihydropyridine-3-carbonitrile is used
5- (imidazolo [1,2-a] pyridine-6-yl) -6-methyl-2-oxo-1,2-dihydropyridine-3-formonitrile This substance has extraordinary uses in the fields of medicine and materials.
In the field of medicine, it may be a promising lead compound. Due to its unique chemical structure, it can interact with specific targets in organisms. It may regulate related biological signaling pathways to achieve the purpose of treating diseases. For example, in anti-tumor research, some compounds containing similar structures can inhibit the proliferation of tumor cells and induce their apoptosis. This compound may also have similar activities, adding new possibilities for the research and development of anti-cancer drugs. In terms of neurological diseases, it may be helpful for the treatment of epilepsy, Parkinson's disease and other diseases by regulating neurotransmitter transmission and affecting nerve cell activity.
In the field of materials, due to the characteristics given by its special structure, it may be used to prepare functional materials. For example, in organic photoelectric materials, it may exhibit good photoelectric properties and be used to manufacture organic Light Emitting Diodes (OLEDs), solar cells and other devices. The distribution of electron clouds and conjugated systems in its structure may affect the characteristics of charge transport and light absorption and emission to optimize device performance. Or in terms of sensor materials, by virtue of selective interaction with specific substances, it is designed and modified to detect specific ions and molecules, and achieve accurate detection of environmental pollutants and biomarkers.
What is the market outlook for 5- (imidazo [1,2-a] pyridin-6-yl) -6-methyl-2-oxo-1, 2-dihydropyridine-3-carbonitrile?
There are currently compounds 5 - (imidazolo [1,2 - a] pyridine - 6 - yl) - 6 - methyl - 2 - oxo - 1,2 - dihydropyridine - 3 - formonitrile, and their market prospects are related to many aspects.
Since its existence, it has gradually emerged in the field of medicinal chemistry. Guanfu Pharmaceutical Research and Development, this compound has a unique structure and potential biological activity, which can be the basis for the creation of new drugs. In view of the current medical needs, there is a demand for new drugs to fight a variety of diseases, and this compound may find a place in the fields of antivirus and antitumor. Due to the similarity between its structure and known active ingredients, researchers hope to develop specific drugs to solve the suffering of patients, so it has a bright future in the pharmaceutical research and development market.
The chemical field should not be underestimated. As an organic synthesis intermediate, it can be derived from many organic compounds. With the growth of demand for fine chemicals in the chemical industry, this compound may become a key raw material for the synthesis of high value-added products. If the production process is mature and the cost is controllable, chemical companies will favor it, and the market demand may rise accordingly.
However, its market road is not smooth. The complexity of the synthesis process is the most important problem. If it cannot be optimized, the cost will not be reduced, and the market competitiveness will be weak. Furthermore, although the biological activity has potential, it still needs a lot of experimental verification. Pre-clinical and clinical trials are time-consuming and laborious, and if the results are poor, marketing activities will be hindered.
Overall, the market prospect of 5- (imidazolo [1,2-a] pyridine-6-yl) -6-methyl-2-oxo-1,2-dihydropyridine-3-formonitrile is like a field to be cultivated, with potential and challenges coexisting. If scientific research and industry work together to overcome technical difficulties, it may be able to shine in the market.