5-HYDROXY-PYRIDINE-2-CARBOXYLIC ACID METHYL ESTER

Methyl 5-hydroxy-pyridine-2-carboxylate, an organic compound. Among its physical properties, its appearance is often white to pale yellow crystalline powder, with a certain melting point, and it melts into a liquid state at a specific temperature. This property is conducive to controlling its state in different experimental and industrial processes.
Talking about chemical properties, due to the presence of active groups such as hydroxyl groups and ester groups, the chemical activity is quite high. Hydroxy groups can participate in many reactions, such as esterification with acids to form new ester compounds. In alkaline environments, hydroxyl groups can dissociate hydrogen ions, showing a certain acidity. The ester group can be hydrolyzed under acidic or basic conditions. When hydrolyzed in acid, 5-hydroxy-pyridine-2-carboxylic acid and methanol are formed; when hydrolyzed in alkaline, 5-hydroxy-pyridine-2-carboxylic acid and methanol are formed.
The pyridine ring structure of the compound gives it unique chemical stability and electronic properties. The nitrogen atom on the pyridine ring can participate in the coordination reaction to form complexes with metal ions. This property may have important applications in the fields of catalysis and materials science. And the conjugated system in its structure makes the compound have certain optical properties, such as being irradiated with specific wavelengths of light, or capable of absorbing and emitting photons, which has potential uses in the field of optical materials.

Methyl 5-hydroxy-pyridine-2-carboxylate is one of the organic compounds and has important uses in many fields.
In the field of medicinal chemistry, it is often a key intermediate in drug synthesis. The structural properties of this compound enable it to participate in a variety of chemical reactions. After clever design and transformation, drug molecules with specific pharmacological activities can be prepared. For example, some innovative drug development targeting specific disease targets, methyl 5-hydroxy-pyridine-2-carboxylate may be used as a starting material to gradually construct drugs with complex structures and precise therapeutic effects through a series of chemical modifications and reaction steps.
In the field of materials science, it also plays an important role. Because of its unique chemical structure, it can be used to synthesize polymer materials with special properties. If it is polymerized with other monomers, the resulting polymer may have excellent physical and chemical properties, such as good thermal stability, mechanical properties or optical properties, etc., and has potential applications in electronic devices, optical materials and other fields.
Furthermore, in organic synthetic chemistry, methyl 5-hydroxy-pyridine-2-carboxylate is a building block commonly used by organic synthetic chemists. Its diverse reaction check points provide the possibility to construct various complex organic molecular structures. Chemists can achieve efficient synthesis of complex organic compounds by selective reactions of their hydroxyl and ester groups, expand the structural diversity of organic compounds, and lay the foundation for exploring new substances and new properties.
In addition, in the field of agricultural chemistry, it may be used as an important raw material for synthesizing pesticides or plant growth regulators. Through appropriate chemical modification, it can be endowed with specific biological activities, which can be used to control crop diseases and pests or regulate plant growth and development, and improve crop yield and quality. In short, methyl 5-hydroxy-pyridine-2-carboxylate shows value and potential in many fields due to its unique structure.

There are various ways to prepare methyl 5-hydroxy-pyridine-2-carboxylic acid. First, it can be obtained by esterification of 5-hydroxy-pyridine-2-carboxylic acid and methanol under acid catalysis. During this process, an appropriate amount of 5-hydroxy-pyridine-2-carboxylic acid is placed in a reaction vessel, excess methanol is added, and strong acids such as sulfuric acid or p-toluenesulfonic acid are used as catalysts. Heat and stir, and the reaction system is maintained at a certain temperature range, such as 60-80 ° C. After several hours of reaction, the reaction liquid is cooled, the catalyst is neutralized in alkali solution, and then excess methanol is removed by distillation, followed by extraction, column chromatography, etc., to obtain the target product.
Furthermore, it can be prepared by functional group conversion from suitable pyridine derivatives. For example, first find pyridine derivatives with functional groups that can be converted into hydroxyl and ester groups, such as 5-halo-pyridine-2-carboxylic acid esters. Taking 5-chloro-pyridine-2-carboxylic acid methyl ester as an example, nucleophilic substitution reaction can be used to replace chlorine atoms with hydroxyl groups under heating conditions with appropriate nucleophilic reagents, such as sodium hydroxide aqueous solution, to generate 5-hydroxy-pyridine-2-carboxylic acid methyl ester. This reaction needs to control the reaction temperature and time to prevent overreaction from causing product decomposition or by-products. After the reaction is completed, the product is purified through neutralization, extraction, distillation, etc.
or synthesized through a pyridine ring construction strategy. With suitable raw materials, such as small molecule compounds containing nitrogen and oxygen atoms, pyridine rings are constructed through multi-step reactions, and hydroxyl and ester groups are introduced at the same time. For example, β-ketone esters and ammonia or amine compounds undergo condensation cyclization under specific conditions to form a pyridine ring structure. During the reaction, the reaction conditions, such as temperature, pH and the ratio of reactants, need to be precisely regulated to make the reaction proceed according to the predetermined path to generate the desired 5-hydroxy-pyridine-2-carboxylic acid methyl ester, and subsequent steps need to be separated and purified to obtain a pure product.

I have not obtained the exact number of "methyl 5-hydroxy-pyridine-2-carboxylate" in the market price range. This is due to the complex and changeable market conditions, and the price audience is influenced by many factors.
First, the price of raw materials fluctuates. The supply of raw materials required for the preparation of this compound and the market supply and demand situation can fluctuate the price of raw materials, which in turn affects the price of finished products. If raw materials are scarce, the price will rise, and the finished product will also be expensive.
Second, the preparation method is related to the cost. Different production methods have different difficulties, required equipment and energy consumption. The method of high efficiency and low cost can make the product price close to the people; the method of cumbersome and high consumption will lead to higher prices.
Third, the power of market demand cannot be underestimated. If the demand for this compound in the fields of medicine and chemical industry increases sharply at some time, the supply is in short supply, and the price will rise; on the contrary, if the demand is weak, the price may drop.
Fourth, regional factors also have an impact. In different places, due to logistics costs, tax differences, and local market competition, prices are different.
Although I do not know the specific price range, if you want to know, you can consult chemical raw material suppliers, chemical reagent sellers, or refer to chemical product trading platforms for quotations to obtain more accurate price information.

Methyl 5-hydroxy-pyridine-2-carboxylate, this is an organic compound. Its storage conditions are of great significance, which is related to the stability and quality of the compound.
According to the concept of "Tiangong Kaiwu", the storage of all things should be checked for their properties. Methyl 5-hydroxy-pyridine-2-carboxylate has specific chemical properties, and the temperature and humidity of the first environment during storage. It should be stored in a cool place. Due to high temperature or enhanced molecular activity of the compound, chemical reactions are triggered and its deterioration is caused. The temperature should not exceed 25 ° C. Humidity is also critical. An over-humid environment or a compound that absorbs moisture affects the purity. The relative humidity should be controlled at 40% - 60%.
Furthermore, this compound should be avoided from coexisting with oxidizing agents, acids, and alkalis. Due to its chemical structure, it is easy to react when encountering such substances, damaging its own structure and properties. Storage containers also need to be carefully selected. Sealed containers made of glass or specific plastics should be used to ensure that they are not disturbed by external substances. Glass containers are chemically stable and can prevent compounds from reacting with the container; sealing can block air and moisture.
In addition, the storage place should be well ventilated to disperse possible harmful gases, and should be kept away from fire and heat sources, as it may be flammable or risk thermal decomposition.
Store methyl 5-hydroxy-pyridine-2-carboxylate in a cool, dry and ventilated environment to avoid contact with incompatible substances, choose a suitable storage container and seal it, so as to ensure its quality and stability for subsequent use.