5-Hydroxy-6-bromo-2-(trifluoromethyl)pyridine

5-Hydroxy-6-bromo-2- (trifluoromethyl) pyridine is one of the organic compounds. It has a wide range of uses and has important applications in many fields.
In the field of medicinal chemistry, such compounds are often used as key intermediates. Due to the special substituents attached to the pyridine ring, it is endowed with unique chemical properties and biological activities. Through organic synthesis, it can be converted into drug molecules with specific pharmacological activities. For example, it may be used to develop new therapeutic drugs for specific diseases, to act on specific biological targets in the body, and to intervene in physiological and pathological processes, which is of great significance for the study of disease treatment.
In the field of materials science, 5-hydroxy-6-bromo-2 - (trifluoromethyl) pyridine also shows unique value. Due to its fluorine atom, the compound has excellent properties such as chemical resistance and low surface energy. It can be introduced into the structure of polymer materials to prepare high-performance functional materials. For example, it can be used to make special coating materials, which can significantly improve the protective performance and service life of materials. It has potential application prospects in industries with strict material performance requirements such as aerospace and automobile manufacturing.
In pesticide chemistry, this compound may be an important starting material for the synthesis of new pesticides. Pyridine derivatives often have unique biological activities against certain pests or pathogens. Through rational molecular design and modification, high-efficiency, low-toxicity and environmentally friendly pesticide products can be developed, which helps to improve the yield and quality of crops and ensure the sustainable development of agricultural production.
In short, 5-hydroxy-6-bromo-2 - (trifluoromethyl) pyridine has important uses in many fields such as medicine, materials, and pesticides, providing a key material basis and research direction for the development of related fields.

5-Hydroxy-6-bromo-2- (trifluoromethyl) pyridine is a kind of organic compound. Its physical properties are of great research value, and it is said in ancient Chinese.
This compound is often solid at room temperature and pressure. Looking at its color, it is mostly white or off-white powder, and its texture is delicate, like the first snow in winter, light and uniform.
When it comes to the melting point, it is about a specific temperature range. This temperature is the critical point for a substance to change from solid to liquid. When the temperature gradually rises, the compound is like spring ice when it is warm, and slowly melts into a liquid state. The characteristics of this melting point can help to identify its purity and characteristics.
As for solubility, it shows different behaviors in many common organic solvents. In some polar organic solvents, such as alcohols, there is a certain solubility, just like fish entering water, it can be dispersed and fused with it; however, in non-polar solvents, its solubility is quite limited, just like oil and water, which is difficult to blend.
Its density is also one of the important physical properties. The density is related to the mass per unit volume of the substance. The density of this compound determines its position in different media. In specific experimental or industrial applications, this property affects its separation, mixing and other operations.
In addition, its appearance and crystal form also contain a lot of information. Viewed through a microscope, it can be seen that the arrangement and structure of its crystal forms are either regular and orderly, or slightly different, which are closely related to the internal structure and formation conditions of the compound. All these physical properties play a key guiding role in chemical research, industrial production and related application fields, and are the cornerstone for exploring its chemical properties and practical uses.

The common methods for synthesizing 5-hydroxy-6-bromo-2- (trifluoromethyl) pyridine are as follows.
First, the compound containing the pyridine structure is used as the starting material and is obtained by multi-step reactions such as halogenation and hydroxylation. First, the pyridine derivative is subjected to specific reaction conditions and interacts with the brominating reagent to realize the substitution of the bromine atom at the specific position of the pyridine ring. This process requires strict control of the reaction temperature, time and reagent dosage to ensure the accuracy of the bromination check point. Then, the introduction of hydroxyl groups can be achieved by means of nucleophilic substitution reactions. Appropriate nucleophilic reagents are selected and reaction conditions are optimized to improve the yield and selectivity of the hydroxylation reaction.
Second, it can be synthesized by the strategy of constructing pyridine rings. Pyridine rings are constructed by multi-step cyclization using small molecule compounds containing fluorine, bromine and hydroxyl groups. For example, based on compounds containing functional groups such as carbonyl and amino groups, in a suitable catalyst and reaction environment, intramolecular cyclization is promoted, and the required bromine, fluorine and hydroxyl functional groups are introduced at the same time. This path requires in-depth understanding of the mechanism of cyclization and careful design of reaction steps to improve the purity and yield of the target product.
Third, the coupling reaction catalyzed by transition metals is also an effective way. Select suitable halogenated pyridine derivatives and react with reagents containing trifluoromethyl groups under the action of transition metal catalysts (such as palladium, nickel, etc.). At the same time, bromine atoms and trifluoromethyl groups on the pyridine ring are introduced. Subsequently, hydroxyl groups are introduced through hydroxylation reaction. This method requires precise regulation of catalyst dosage, ligand selection and reaction solvent conditions to optimize reaction efficiency and product selectivity.
Each synthesis method has its own advantages and disadvantages. In actual operation, it is necessary to comprehensively consider and carefully select the appropriate synthesis strategy according to many factors such as the availability of starting materials, the controllability of reaction conditions, and the purity and yield requirements of the target product.

I look at this question, but I am inquiring about the price of 5-hydroxy-6-bromo-2- (trifluoromethyl) pyridine in the market. However, the price of the market often changes due to many reasons.
First, the source of this product is different, and the price is also different. If it is refined by a large factory, the quality is high or high; if it is produced by a small factory, although the price is low, the quality may be different. Second, the quantity has a great impact on the price. Those who buy a large quantity often give discounts in order to obtain a big profit; those who buy a small quantity, the price may be high. Third, the circulation of time also causes the price to change. The supply and demand of the market changes with the years. If you need to be prosperous and the supply is small, the price will rise; if you need to be prosperous and the demand is small, the price will drop.
If you want it in the market today, you can visit the merchants of chemical reagents. Common chemical reagent platforms, such as Sinopharm, search banner, etc., may have this thing. Go to its website and check it in detail, the price can be clearly understood. However, the price is often not fixed, or fluctuates from time to time. Or consult the market of chemical raw materials, visit various merchants in person, or hear different prices, and then weigh. In short, if you want to know the exact price, you should inquire more and more to check the status of the market, and you can get a more appropriate price.

5-Hydroxy-6-bromo-2- (trifluoromethyl) pyridine, this is a chemical substance, and its storage conditions are very critical. Store this substance in a cool, dry and well-ventilated place.
A cool environment can avoid high temperature causing its properties to change. High temperature often promotes chemical reactions, or causes the substance to decompose and deteriorate, damaging its chemical properties and purity. Therefore, when looking for a lower temperature, it is generally not more than 30 ° C.
A dry place can prevent moisture intrusion. If moisture comes into contact with the substance, it may cause reactions such as hydrolysis. Especially those containing hydrophilic groups such as hydroxyl groups are more likely to absorb moisture. Once moisture is absorbed, or agglomerated or deteriorated, the ambient humidity should be controlled at a relatively low level, such as 40% - 60%.
Well ventilated, it can ensure air circulation, disperse volatile gas in time, avoid danger caused by its accumulation, and maintain a dry environment.
In addition, because of its certain chemical activity, it should be stored away from fire, heat sources, strong oxidants, strong bases, etc. If mixed with strong oxidants, or cause severe oxidation reactions; in case of strong bases, or acid-base neutralization reactions, the substance will fail.
Storage containers should also be considered. Corrosion-resistant containers, such as glass or specific plastic containers, should be tightly sealed to prevent air and moisture from invading. In this way, the chemical properties of 5-hydroxy-6-bromo-2 - (trifluoromethyl) pyridine are kept stable, and their original quality and purity are maintained for a long time.