5 Hydroxy 2 Pyridinecarboxylic Acid
pyridine pyrrole pyrazine piperidine piperazine

5-Hydroxy-2-pyridinecarboxylic acid

    Specifications

    HS Code

    642940

    Chemical Formula C6H5NO3
    Molar Mass 139.11 g/mol
    Appearance Solid
    Color Typically white or off - white
    Odor Odorless (usually)
    Solubility In Water Moderately soluble
    Melting Point 225 - 227 °C
    Pka Value Around 3.5 (approximate for the carboxylic acid group)
    Boiling Point Decomposes before boiling

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    General Information
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    Frequently Asked Questions

    As a leading 5-Hydroxy-2-pyridinecarboxylic acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What is the chemistry of 5-Hydroxy-2-pyridinecarboxylic acid?
    5-Hydroxy-2-pyridinecarboxylic acid, this is an organic compound. Looking at its chemical properties, it is acidic, and because it contains a carboxyl group (-COOH), this carboxyl group can release protons under suitable conditions, developing acidic properties.
    In addition, its hydroxyl group (-OH) also has certain activity. The hydrogen atom of the hydroxyl group may participate in the formation of hydrogen bonds, which affects its physical and chemical properties. For example, the presence of hydrogen bonds may affect the solubility of the compound in solvents. In some chemical reactions, hydroxyl groups can be substituted or participate in reactions such as oxidation.
    The presence of pyridine rings gives the compound unique electronic properties. The pyridine ring is aromatic, and its electron cloud distribution characteristics enable the compound to participate in a variety of electrophilic substitution reactions. In addition, the nitrogen atom on the pyridine ring has lone pairs of electrons, which can be used as an electron donor to participate in coordination reactions and form complexes with metal ions.
    5-Hydroxy-2-pyridinecarboxylic acid exhibits various chemical properties such as acidic, can participate in hydrogen bond formation, substitution reactions, oxidation reactions and coordination reactions due to its carboxyl, hydroxyl and pyridine ring functional groups.
    What are the main uses of 5-Hydroxy-2-pyridinecarboxylic acid?
    5-Hydroxy-2-pyridinecarboxylic acid, this substance has a wide range of uses. In the field of medicine, it can be used as a key intermediate. Due to its specific chemical structure and activity, it can participate in the synthesis of a variety of drugs, helping to develop new therapeutic drugs, such as antibacterial and anti-inflammatory drugs, and contributing to human health and well-being.
    In the chemical industry, 5-hydroxy-2-pyridinecarboxylic acid also plays an important role. It can act as a catalyst or auxiliary agent to affect many chemical reaction processes. In organic synthesis reactions, it can adjust the reaction rate and selectivity, making the reaction more efficient and accurate to achieve the desired product, improving chemical production efficiency and product quality.
    Furthermore, in the field of materials science, 5-hydroxy-2-pyridinecarboxylic acid may play a unique role. Or it can participate in material modification and endow the material with excellent characteristics such as better stability and adsorption. For example, in the preparation of some adsorption materials, adding this substance can optimize the adsorption capacity of the material to specific substances, so that it can show excellent performance in environmental treatment and material separation.
    In addition, it also has potential uses in the agricultural field. Or it can be used as a component of plant growth regulators to affect plant growth and development, such as promoting plant root growth, enhancing plant stress resistance, etc., to help increase agricultural production and income, and promote sustainable agricultural development. Overall, 5-hydroxy-2-pyridinecarboxylic acid has significant functions in many fields and is of great significance to the development of various industries.
    What are the synthetic methods of 5-Hydroxy-2-pyridinecarboxylic acid?
    The synthesis of 5-hydroxy-2-pyridinecarboxylic acid is a subject of much concern in the field of chemistry. To make this product, several ways can be achieved.
    One can start from pyridine. First, under specific conditions, pyridine is substituted with suitable reagents and reaction processes, and a carboxyl group is introduced at the 2nd position of the pyridine ring, and then a hydroxyl group is introduced at the 5th position. In this process, precise control of reaction conditions such as temperature, pressure, ratio of reactants, and choice of catalyst is required. Too high or too low temperature may cause the reaction to be biased towards side reactions, or the reaction rate may be too slow. Pressure also affects the reaction process, and some reactions can achieve the best results under specific pressures.
    Second, a compound containing a pyridine structure is used as the starting material. If the compound has a group that can be converted into a carboxyl group at the 2nd position of the pyridine ring and a group that can be converted into a hydroxyl group at the 5th position, the group can be converted by clever chemical reactions. For example, the ester group at the 2nd position can be converted into a carboxyl group by reactions such as hydrolysis, and the halogen atom at the 5th position can be converted into a hydroxyl group by reactions such as nucleophilic substitution. However, in this process, attention should be paid to the impact of each reaction step on other groups, and protection and de-protection strategies should be taken in a timely manner to prevent other groups from being damaged during the reaction.
    Third, there are also those who try to prepare it by biosynthesis. The synthesis of 5-hydroxy-2-pyridinecarboxylic acid is achieved by using specific microorganisms or enzymes through complex metabolic pathways in organisms. This method may have the advantages of mild reaction conditions and high selectivity compared to chemical synthesis methods. However, biosynthesis also faces many challenges, such as harsh culture conditions for microorganisms, and difficulty in maintaining the stability and activity of enzymes.
    All these synthesis methods have advantages and disadvantages. Although chemical synthesis methods are complicated and strictly controlled, they can be prepared on a large scale; although biosynthesis has the potential for green and high efficiency, the technology still needs to be perfected. Synthesizers should carefully choose the appropriate synthesis method according to their own needs, resources and technical conditions.
    What is the price range of 5-Hydroxy-2-pyridinecarboxylic acid in the market?
    5-Hydroxy-2-pyridinecarboxylic acid, the range of market prices is difficult to determine. There are many reasons for this. First, the number of producers and the quality of the product can make the price vary. Those who are good in production and quality, the price is high; those who are wide in production and of average quality, the price is low. Second, the number of seekers is also the main reason. If the demand of various industries is prosperous, the demand is too high, and the price will rise; if the demand is thin, the supply is too high, and the price will drop. Third, the state of the city changes, such as the prosperity and decline of the past, and the rise and fall of the government, all are related to the price.
    Looking at the past examples, in the chemical raw material market, the price of this compound often moves with time. In the past, if it was difficult to harvest and transport raw materials and the manufacturing process changed, the price might be as high as a few gold per gram. And if the production capacity increases greatly and the demand does not rise, the price may drop to a few cents per gram.
    If you want to confirm the price now, you should carefully examine the market conditions. Or consult chemical manufacturers, or observe various e-commerce platforms and industry information, and synthesize the prices quoted by many parties to understand the approximate current price. However, the market situation changes rapidly, and the price is also difficult to maintain. If you want to obtain a definite number, you must constantly observe the changes in time to cope with the volatility of the market.
    What are the storage conditions for 5-Hydroxy-2-pyridinecarboxylic acid?
    5-Hydroxy-2-pyridinecarboxylic acid, this is a fine chemical substance. The most important thing for its preservation is in a dry environment. If it is covered in a humid place, it is very susceptible to moisture, causing changes in its properties, affecting its quality and utility. It is necessary to choose a dry and well-ventilated storage, and it should be kept away from water sources and places with heavy moisture.
    For the second time, temperature is also the key. It should be stored in a cool place to avoid hot topics. If it is overheated, or a chemical reaction occurs, it will decompose or deteriorate. Generally speaking, the temperature should be maintained at 15 ° C to 25 ° C. Excessive temperature may enhance the activity of molecules and cause unnecessary reactions; too low temperature, although it will not cause immediate damage, may affect its performance for subsequent use.
    Furthermore, protection from light is also indispensable. Energy in light may promote photochemical reactions, damaging its structure and properties. Therefore, it should be stored in brown bottles or materials with light-shielding packaging to block light intrusion.
    And this material may have certain chemical activity and cannot be co-stored with strong oxidizing agents, strong reducing agents and substances with different acidity and alkalinity. Due to contact with it, or violent reaction, it endangers safety and also damages its quality. It must be stored in categories and marked carefully for management and access to ensure its stability and safety during storage.