5-formyl-2-hydroxypyridine

5-Formyl-2-hydroxypyridine is one of the organic compounds. It has special chemical properties, which are important for chemical research and industrial applications.
This compound contains formyl (-CHO) and hydroxyl (-OH) on the pyridine ring. Formyl groups are active and can perform many reactions. If it can react with nucleophiles, it is common to react with amines to form imines. This reaction is commonly used in the preparation of nitrogen-containing heterocyclic compounds in organic synthesis because it can introduce nitrogen-containing structures and expand the complexity and functionality of molecules.
Hydroxyl groups are also active check points. The hydrogen of the hydroxyl group has a certain acidity, which can be left under the action of an appropriate base, so that the compound has a certain nucleophilicity. And the hydroxyl group can participate in the formation of hydrogen bonds, which affects the physical properties of the compound, such as melting point, boiling point and solubility. Under certain conditions, the hydroxyl group can be substituted, such as reacting with halogenated hydrocarbons to form ether compounds, which is also an important method for constructing carbon-oxygen bonds in organic synthesis.
The pyridine ring of 5-formyl-2-hydroxypyridine has aromatic properties, which makes its structure stable. However, the substituents on the ring can affect the electron cloud density distribution of the ring. Formyl group is an electron-withdrawing group and hydroxyl group is a donator group. The reactivity and selectivity of pyridine ring are unique when they work together. In electrophilic substitution reactions, the localization effect of substituents is affected by the combined electronic effects of the two, which can guide the reaction to occur at a specific location, which is of great significance for the synthesis of derivatives with specific structures.
Furthermore, 5-formyl-2-hydroxypyridine can be used as a multifunctional synthesizer due to its multiple active groups. By rationally designing the reaction path, it can be converted into a variety of complex organic compounds, which have potential applications in pharmaceutical chemistry, materials science and other fields.

5-formyl-2-hydroxypyridine is an important intermediate in organic synthesis. The common synthesis methods are as follows:
First, 2-hydroxypyridine is used as the starting material and prepared by the Vilsmeier-Haack reaction. In this reaction, N, N-dimethylformamide (DMF) reacts with phosphorus oxychloride (POCl) to form a viable intermediate. The nitrogen atom in 2-hydroxypyridine undergoes nucleophilic substitution with the active intermediate, and then hydrolyzes to obtain 5-formyl-2-hydroxypyridine. The conditions of this method are mild and the yield is acceptable. However, the reagent phosphorus oxychloride used is corrosive and the operation needs to be cautious.
Second, 2,5-dihydroxypyridine is used as the raw material and synthesized by selective formylation reaction. A system composed of trifluoromethanesulfonic anhydride (Tf 2O O) and DMF can be selected to achieve selective formylation of the 5-hydroxyl group under appropriate conditions, and then the target product can be obtained. This approach has good selectivity, but the acquisition of the raw material 2,5-dihydroxypyridine may be inconvenient.
Third, the coupling reaction catalyzed by transition metals. For example, using halogenated-2-hydroxypyridine and formaldehyde derivatives as raw materials, under the action of transition metal catalysts such as palladium (Pd) or copper (Cu), carbon-carbon bonds are formed through coupling reaction to achieve the synthesis of 5-formyl-2-hydroxypyridine. This method is efficient and innovative, but the catalyst price is higher and the reaction conditions are more stringent.
All this synthesis method has advantages and disadvantages. Experimenters need to carefully weigh and choose the best one according to the availability, cost, yield and selectivity of raw materials.

5-formyl-2-hydroxypyridine, which is used in many fields. In the field of medicine, it is often a key intermediate for the synthesis of drugs. Due to its unique chemical structure, it can participate in many organic reactions and help create compounds with specific biological activities. For example, when synthesizing some drugs with antibacterial and anti-inflammatory effects, 5-formyl-2-hydroxypyridine can introduce key functional groups into molecules, enabling drug molecules to precisely act on pathogenic targets and improve therapeutic effects.
In the field of materials science, it also shows important value. It can be used to prepare functional materials, such as participating in the synthesis of specific optoelectronic materials. With its structural characteristics, the optical and electrical properties of materials can be regulated, and then applied to organic Light Emitting Diode (OLED), solar cells and other devices to improve the performance of such devices, such as improving luminous efficiency and enhancing photoelectric conversion efficiency.
In the field of organic synthetic chemistry, 5-formyl-2-hydroxypyridine is an important building block for organic synthesis, which facilitates the construction of complex organic molecular structures. Chemists can use various chemical reactions, such as condensation reactions, addition reactions, etc., to build a rich and diverse molecular framework, expand the variety and structural complexity of organic compounds, and promote the development of organic synthetic chemistry.

5-Formyl-2-hydroxypyridine is one of the organic compounds. Its physical properties are unique, let me tell them one by one.
Looking at its appearance, under normal conditions, it may be a crystalline solid, white, delicate and uniform, just like the snow that falls in the early winter, shining brightly. This substance has a specific melting point, about 160-165 ° C. When the temperature gradually rises, its lattice structure begins to disintegrate, slowly turning from solid to liquid, just like ice and snow in the warm sun, quietly melting.
When it comes to solubility, 5-formyl-2-hydroxypyridine exhibits good solubility in polar organic solvents, such as methanol, ethanol, dimethyl sulfoxide, etc. Taking methanol as an example, the two contact, just like the water of fish, and quickly blend to form a uniform solution. This is because the compound molecules and polar solvent molecules can form hydrogen bonds and other interactions, so they can be mutually soluble. However, in non-polar solvents, such as n-hexane and toluene, their solubility is very small, and the two seem to be distinct and difficult to blend, due to the difference in the forces between molecules.
Furthermore, it has a certain volatility. Although the volatility is not strong, under certain conditions, such as heating or placing in a ventilated place, some molecules will also escape in the air. And because its molecular structure contains hydroxyl groups and formyl groups, both of which have a certain polarity, resulting in greater molecular polarity, which affects many aspects of its physical properties. If the intermolecular force is strong, its melting point and boiling point are relatively high, which is more stable than some non-polar compounds with similar structures. In conclusion, the physical properties of 5-formyl-2-hydroxypyridine are determined by its unique molecular structure, and it has important application value in the fields of organic synthesis, medicinal chemistry, etc.

I look at your question, but I am inquiring about the market price of 5-formyl-2-hydroxypyridine. However, the price in the market often varies with time, place, quality and supply and demand, so it is difficult to say for sure.
This 5-formyl-2-hydroxypyridine, if it is traded in various chemical trading places, its price or quantity depends on the quantity. When the quantity is small, the price may be slightly higher; if the buyer wants a large quantity, the merchant may offer a discount in order to promote the transaction.
And the quality of this compound is also the key to pricing. Refined high-quality products must be more expensive than crude ones. And where it is located, if it is in a place where the chemical industry is prosperous and the logistics is convenient, the price may be relatively easy; if it is remote and the transportation is difficult, the price should also rise.
Furthermore, the supply and demand of the city is the cardinal of the price. If there are many seekers and few suppliers, the price will rise; if the supply exceeds the demand, the price will fall.
To know the exact price, you can visit a business in the chemical market, or consult a platform for trading chemical raw materials, and ask the merchant in detail to get a near-real price.