5-Fluoro-2-methoxypyridine-4-boronic acid

5-Fluoro-2-methoxypyridine-4-boronic acid is a crucial reagent in the field of organic synthesis. Its unique physical and chemical properties have far-reaching effects on many organic reactions.
When it comes to physical properties, under normal conditions, 5-fluoro-2-methoxypyridine-4-boronic acid is mostly white to off-white solid, which is easy to store and use. Its melting point is within a specific range, which is of great significance in the identification and purification process. With the determination of melting point, the purity of the substance can be determined, and it can also help distinguish it from other similar compounds.
In terms of chemical properties, the boric acid group gives it unique activity. This boric acid group can participate in the classic Suzuki coupling reaction, which is widely used in the construction of carbon-carbon bonds. In the reaction, the boric acid group of 5-fluoro-2-methoxypyridine-4-boronic acid can be coupled with halogenated aromatics or olefins under the action of palladium catalysts and bases to form a series of organic compounds with specific structures, which are widely used in drug synthesis, materials science and many other fields. For example, in drug development, complex drug molecular skeletons can be constructed through this reaction, laying the foundation for the creation of new drugs.
Furthermore, the fluorine atom and methoxy group in the compound also affect its chemical properties. Fluorine atoms have strong electronegativity, which can change the electron cloud distribution of the molecule, which in turn affects the reactivity and selectivity. Methoxy groups can regulate the reaction check point and reactivity of the molecule through electronic effects and spatial effects. The synergistic effect of the two makes 5-fluoro-2-methoxypyridine-4-boronic acid exhibit diverse reaction properties under different reaction conditions, providing rich reaction path choices for organic synthesis chemists.

5-Fluoro-2-methoxypyridine-4-boronic acid has a wide range of uses and is often a key intermediate in the field of organic synthesis. It can participate in many chemical reactions, such as the Suzuki-Miyaura coupling reaction, which is an important means of constructing carbon-carbon bonds. In this reaction, 5-fluoro-2-methoxypyridine-4-boronic acid can efficiently form biaryl or alkenylated products with specific structures with halogenated aromatics or alkenes under the action of palladium catalysts and bases. These products are of great significance in the field of medicinal chemistry, and the synthesis of many drug molecules depends on this reaction to build a key skeleton.
Furthermore, in the field of materials science, 5-fluoro-2-methoxypyridine-4-boronic acid is also useful. The materials prepared by the reactions in which they participate may have special optoelectronic properties and can be applied to the preparation of optoelectronic devices such as organic Light Emitting Diodes (OLEDs) and solar cells. Because it can endow materials with unique electronic structures and molecular configurations, it can optimize the optical and electrical properties of materials.
In addition, in the field of agricultural chemistry, compounds synthesized from 5-fluoro-2-methoxypyridine-4-boronic acid may be used as new pesticides. The modified pyridyl boronic acid derivatives may have high killing or inhibitory effects on specific pests, and may have lower environmental toxicity and higher selectivity than traditional pesticides, providing a new way for agricultural pest control.

To prepare 5-fluoro-2-methoxypyridine-4-boronic acid, the following method is often followed.
Take 5-fluoro-2-methoxypyridine as the starting material, and combine it with a suitable halogenated reagent, such as N-bromosuccinimide (NBS), in a suitable reaction solvent, such as carbon tetrachloride (CCl), under the action of an initiator such as benzoyl peroxide (BPO), the radical reaction can be initiated by heating, and the bromine atom can be introduced at the 4-position of the pyridine ring to obtain 5-fluoro-2-methoxy-4-bromopyridine. This step requires attention to the reaction temperature and the amount of reagents to control side reactions.
The resulting 5-fluoro-2-methoxy-4-bromopyridine is then reacted with an organometallic reagent, such as n-butyllithium (n-BuLi), in an anhydrous ether or tetrahydrofuran (THF) solvent at a low temperature such as -78 ° C to form a lithiated intermediate. This intermediate is extremely sensitive to air and water, and the operation must be carried out under the protection of an inert gas atmosphere, such as nitrogen or argon.
Subsequently, the above lithiated intermediate is reacted with a borate ester, such as trimethyl borate (B (OMe)). After the reaction is completed, 5-fluoro-2-methoxypyridine-4-boronic acid is hydrolyzed to 5-fluoro-2-methoxypyridine-4-boronic acid after an appropriate amount of dilute acid, such as hydrochloric acid (HCl) solution.
The product can be purified by extraction, column chromatography or recrystallization. Pure 5-fluoro-2-methoxypyridine-4-boronic acid can be obtained. Reaction conditions such as temperature, time, and reagent ratio need to be carefully adjusted to achieve good yield and purity.

5-Fluoro-2-methoxypyridine-4-boronic acid is a commonly used reagent in organic synthesis. During storage, the following things should be paid attention to.
Bear the brunt, the temperature of the storage environment is very important. This compound should be stored in a cool place, and the temperature should be maintained at 2-8 ° C. If the temperature is too high, it may cause the compound to decompose and deteriorate, causing its chemical properties to change and affecting the effect of subsequent use.
Humidity is also a factor that cannot be ignored. It needs to be placed in a dry place, away from moisture. Because it has a certain degree of water absorption, if the ambient humidity is high, it is easy to absorb moisture and agglomerate, or react with water, so that the purity is damaged.
Furthermore, the compound is sensitive to air. When storing, contact with air should be minimized, and sealed packaging can be used. If the seal is not good, the oxygen, carbon dioxide and other components in the air may react with it, resulting in a decrease in quality.
In addition, the choice of storage containers is also very particular. Glass or plastic containers should be used, and the containers should be clean and dry to avoid impurities from mixing. Containers of different materials may interact with compounds, affecting their stability.
The storage place should also be kept away from fire and heat sources, because it is a chemical product, in case of open flame, hot topic or risk of combustion and explosion. In short, proper storage of 5-fluoro-2-methoxypyridine-4-boronic acid is of great significance to ensure its quality and performance, and it must not be taken lightly when operating.

I am looking at the relevant market price of 5 - Fluoro - 2 - methoxypyridine - 4 - boronic acid. However, the market price of this compound is not constant and is determined by many factors.
First, the cost of production has a great impact. The price of raw materials and the complexity of the synthesis process are all related to its production consumption. If raw materials are scarce, or the synthesis requires fine and complicated steps, the cost will rise, and the market price will also increase.
Second, the supply and demand relationship in the market is the key. If the demand for this compound is strong, such as in pharmaceutical research and development, material science and other fields, there is a large demand, but the supply is relatively insufficient, the price will be high; conversely, if there is a lack of demand and excess supply, the price may be reduced.
Third, the difference in suppliers also has an impact. Different suppliers may have different pricing due to different production scales, technical levels, and business strategies. Large suppliers, with economies of scale, may be able to offer relatively low prices; while small suppliers, due to cost constraints, may have slightly higher prices.
Furthermore, geographical factors cannot be ignored. The price of this compound will also vary in different regions due to differences in transportation costs, tax policies, and market competition. In prosperous commercial areas, the competition is intense, and the price may be more reasonable; in remote areas, the price may be slightly higher due to the increase in transportation and other costs.
According to past market conditions, the price of this compound may range from tens to hundreds of yuan per gram. However, this is only a rough estimate. The actual price needs to be consulted in real time with chemical raw material suppliers, chemical trading platforms, etc., to obtain an accurate figure.