5-fluoro-2-methoxy-4-iodopyridine

5 - fluoro - 2 - methoxy - 4 - iodopyridine is an organic compound with unique chemical properties. In its structure, fluorine atoms, methoxy groups and iodine atoms each show characteristics. Fluorine atoms have high electronegativity, which can enhance the lipophilic properties of molecules, change their physical and chemical properties, and affect the solubility, stability and biological activity of compounds. Oxygen atoms in methoxy groups contain lone pair electrons, which can participate in the formation of hydrogen bonds and affect intermolecular interactions. It is reflected in crystal structure and solubility. It also affects the distribution of electron clouds and changes the electronic properties of molecules. Iodine atoms have large relative atomic mass and volume, which affect the molecular spatial structure and electron cloud distribution, can enhance molecular polarity, and have a significant impact on intermolecular forces, affecting physical properties such as boiling point and melting point. In chemical reactions, fluorine and iodine atoms in 5-fluoro-2-methoxy-4-iodopyridine can be used as leaving groups to participate in nucleophilic substitution reactions and react with nucleophilic reagents to form new compounds. Oxygen atoms of methoxy groups can be used as nucleophilic check points and participate in electrophilic substitution reactions. Due to its structural properties, this compound may have important applications in the fields of medicinal chemistry and materials science. In medicinal chemistry, or due to the interaction of structural properties with biological targets, it exhibits biological activity and becomes a potential drug lead compound. In materials science, its unique electronic and physical properties may be used to develop new functional materials.

In the synthesis of 5-fluoro-2-methoxy-4-iodopyridine, the pyridine-containing structure is often used as the starting material.
One method is to start with 2-methoxy pyridine and fluorinate it first. In a suitable solvent, such as dichloromethane, add a fluoride reagent, such as Selectfluor, and a temperature-controlled reaction can obtain 2-methoxy-5-fluoropyridine. In this step, the reagent activity is high, and it is necessary to pay attention to the temperature and reaction process to avoid side reactions.
Then iodine replaces it. Dissolve 2-methoxy-5-fluoropyridine in a suitable solvent, such as N, N-dimethylformamide, add an iodine substitution agent, such as iodine elemental substance and an oxidant (such as hydrogen peroxide or potassium persulfate), and oxidize iodine to obtain 5-fluoro-2-methoxy-4-iodopyridine. In this process, the amount of oxidant and the control of reaction conditions are related to the yield and purity of the product.
Another method uses 5-fluoropyridine as the starting material. Under appropriate conditions, 5-fluoropyridine is reacted with the iodine substitution agent to introduce iodine atoms. 5-Fluoro-4-iodopyridine is obtained by the reaction of iodine and copper salt in a suitable solvent. Then methoxylation is carried out with a methylating agent, such as dimethyl sulfate, in the presence of a base (such as potassium carbonate), and the target product 5-fluoro-2-methoxy-4-iodopyridine can be obtained. In this route, the optimization of the reaction conditions at each step, such as the amount of base, reaction temperature and time, are all key.
Furthermore, if 2-chloro-5-fluoropyridine is used as the starting material. 5-Fluoro-2-methoxy-4-iodopyridine can also be prepared by reacting with sodium methoxide and other methoxylating reagents to replace chlorine atoms with methoxy groups under the action of potassium iodide and catalyst (such as palladium catalyst). This synthesis path, the choice and amount of catalyst have a great impact on the reaction efficiency.

5-Fluoro-2-methoxy-4-iodopyridine is used in many fields. In the field of medicinal chemistry, it is often a key intermediate for the synthesis of new drugs. Due to its unique structure and specific chemical activity, it can be combined with other molecular fragments through various chemical reactions to construct compounds with specific pharmacological activities. For example, when developing antibacterial and antiviral drugs, its structural properties can be cleverly used to optimize the efficacy and selectivity of drugs.
In the field of materials science, 5-fluoro-2-methoxy-4-iodopyridine also has unique contributions. It can be used as a raw material for the synthesis of functional materials, giving the materials special photoelectric properties. Taking the preparation of organic semiconductor materials as an example, it participates in the synthesis process and can effectively regulate the electron transport capacity of the material, laying the foundation for the manufacture of high-performance electronic devices, such as organic Light Emitting Diodes (OLEDs) and organic field effect transistors (OFETs).
In the field of organic synthesis chemistry, this compound is an extremely important synthetic building block. With its fluorine, methoxy, iodine and other functional groups, it can participate in a variety of classical organic reactions, such as nucleophilic substitution reactions, coupling reactions, etc. With this, chemists can create complex and diverse organic molecules, which contribute to the development of organic synthetic chemistry, help to explore novel synthetic pathways and strategies, and continuously expand the structural diversity of organic compounds.

5-Fluoro-2-methoxy-4-iodopyridine is a class of organic compounds that have attracted much attention in the field of fine chemicals. It plays a crucial role in many key fields such as pharmaceutical research and development, pesticide creation, etc., and is often used as an indispensable intermediate. However, its market price is difficult to generalize, because it is influenced by many factors.
First, the cost of raw materials has a deep impact on its price. The fluctuation of the market price of various starting materials required for the synthesis of 5-fluoro-2-methoxy-4-iodopyridine will be directly transmitted to the compound. If raw materials are scarce or difficult to obtain, prices will rise.
Second, the complexity of the preparation process is also the key. If the synthesis process requires a multi-step reaction, and the reaction conditions are strict, such as specific temperature, pressure, catalyst, etc., it will undoubtedly increase the production cost, and then push up the market price.
Third, the market supply and demand situation should not be underestimated. If many pharmaceutical and pesticide companies have strong demand for it, but the supply is relatively insufficient, the price will rise; conversely, if the market demand is weak and the supply is excessive, the price may have a downward trend.
Fourth, the production scale is also closely related to the price. In large-scale production, due to the scale effect, the unit production cost may be reduced, and the price will be more competitive; in small-scale production, the cost is relatively high, and the selling price will also be higher.
Based on past market conditions, the price range of 5-fluoro-2-methoxy-4-iodopyridine is relatively large, ranging from tens to hundreds of yuan per gram. However, the market situation changes, and the price will fluctuate frequently with the changes of the above factors. To know the exact market price, companies and researchers should pay attention to the market dynamics of chemical raw materials in real time, or consult professional chemical product suppliers in detail, in order to obtain accurate price information for comprehensive decision-making.

5-Fluoro-2-methoxy-4-iodopyridine is one of the organic compounds. On its safety and toxicity, the details are as follows.
First of all, the toxicity of this substance is not fully understood due to limited data. However, from the perspective of organic halides, it may have certain toxicity. The introduction of halogen atoms often makes the metabolic pathways of compounds in organisms unusual, and may interact with biological macromolecules such as proteins and nucleic acids. Fluorine atoms have strong electronegativity, or change the distribution of electron clouds of compounds, which in turn affect their chemical reactivity and biological activity. Iodine atoms are relatively large, or interfere with the fit between molecules and biological targets. In experimental animals, or through inhalation, ingestion or skin contact, this compound can cause toxic reactions to varying degrees. Such as on the respiratory system, or irritating the respiratory mucosa, causing cough, asthma and other diseases; in the digestive system, or affecting gastrointestinal function, causing nausea, vomiting, diarrhea genus.
As for safety, in terms of storage, when avoiding heat and open flames, because under specific conditions, there may be a risk of combustion or explosion. Its chemical properties are active, or react with many substances, so it needs to be stored separately from oxidants, reducing agents, acids, bases, etc. to prevent accidents. During operation, the experimenter must wear appropriate protective equipment, such as protective gloves, goggles, lab clothes, etc., to prevent skin contact and splashing into the eyes. If operated in a poorly ventilated place, its volatile gaseous substances may be inhaled, which endangers health, so it needs to be operated in a fume hood. After accidental contact, rinse with plenty of water as soon as possible. If the situation is serious, seek medical treatment immediately.
In short, 5-fluoro-2-methoxy-4-iodopyridine has potential toxicity and safety risks. When handling and using, be careful in accordance with relevant safety procedures to ensure the safety of personnel and the environment.