5-Fluoro-2-hydroxymethylpyridine

5 - Fluoro - 2 - hydroxymethylpyridine is an organic compound with a wide range of uses. In the field of medicinal chemistry, this compound is often used as a key intermediate to synthesize compounds with biological activity. Because of its structure of fluorine atoms and hydroxymethylpyridine parts, special properties can be introduced to target molecules to affect their biological activity, lipophilicity and metabolic stability.
In the field of pesticides, 5 - Fluoro - 2 - hydroxymethylpyridine also has important uses. By modifying its structure and derivatization, high-efficiency, low-toxicity and environmentally friendly pesticides can be prepared for the control of pests and diseases, and to ensure the yield and quality of crops.
In the field of materials science, this compound can be used as a building unit to synthesize functional materials with special photoelectric properties. Its unique structure can endow materials with specific properties such as electron transport and luminescence, and may have potential applications in organic Light Emitting Diode (OLED), solar cells and other fields.
In addition, in organic synthesis chemistry, 5-Fluoro-2-hydroxymethylpyridine is an important raw material for participating in various organic reactions, such as nucleophilic substitution, oxidation, reduction, etc., to construct complex organic molecular structures, providing organic synthesis chemists with rich synthesis strategies and pathways.

The synthesis method of 5-fluoro-2-hydroxymethylpyridine has been known for a long time. There are many methods, and they are described in detail today.
First, fluoropyridine derivatives are used as starting materials. First, a specific fluoropyridine halogen is interacted with a nucleophilic reagent, which requires a potential group containing hydroxymethyl groups. Under appropriate reaction conditions, such as in a suitable solvent, the temperature and reaction time are controlled. The nucleophilic reagent attacks the specific check point of the halogen, and the halogen atom leaves, thereby introducing a structural fragment containing hydroxymethyl groups. After hydrolysis or other suitable conversion steps, the potential hydroxymethyl group is converted into the target hydroxymethyl group, and then 5-fluoro-2-hydroxymethylpyridine is obtained.
Second, pyridine is used as the initial raw material. The pyridine ring is first fluorinated, and a suitable fluorination agent can be selected. In a certain reaction environment, fluorine atoms are selectively introduced into specific positions of the pyridine ring. Then, through the hydroxymethylation reaction, hydroxymethyl groups are introduced into the fluorinated pyridine ring. This hydroxymethylation reaction can be achieved with the help of specific reagents and reaction conditions, such as the use of formaldehyde or its equivalent reagents, under the action of catalysts, nucleophilic substitution or addition-elimination reactions occur with fluorinated pyridine to construct the structure of the target product.
Third, the coupling reaction catalyzed by transition metals. Using fluorine-containing pyridine halide or borate, and hydroxymethyl-containing halide or borate as raw materials, under the catalysis of transition metal catalysts such as palladium, nickel, etc., adding appropriate ligands, bases and solvents, through coupling reactions, fluoropyridine fragments are connected with hydroxymethyl fragments, and then 5-fluoro-2-hydroxymethylpyridine is synthesized. This method requires precise control of the amount of catalyst, the selection of ligands and reaction conditions to improve the selectivity and yield of the reaction.

5 - Fluoro - 2 - hydroxymethylpyridine is an organic compound with unique physical properties. Its properties are mostly white to light yellow crystalline powder at room temperature. It is delicate and uniform in texture, like a natural thing. The melting point of this substance is about 85 - 88 ° C, just like the critical point. At this time, the state of solid and liquid quietly changes, like ice melting in the spring sun.
When it comes to solubility, it can be soluble in many organic solvents, such as methanol, ethanol, etc., just like fish getting water and blending seamlessly. In water, it also has a certain solubility. Although it is not completely miscible, it can also partially blend, like a drizzle moistening the soil and silk infiltration.
Its density is about 1.32g/cm ³, does not float or sink, finds its own proper position in the world, stable and consistent. And with a certain stability, in case of extreme conditions such as strong acid, strong alkali or high temperature, the structure will also change, such as rock in case of fire, although hard, it will melt.
The physical properties of 5 - Fluoro - 2 - hydroxymethylpyridine lay an important foundation for its application in organic synthesis, drug research and development, just as the cornerstone is indispensable for high-rise buildings.

5-Fluoro-2-hydroxymethylpyridine, this is an organic compound with unique chemical properties and important uses in many fields.
Looking at its physical properties, it may be a solid under normal conditions, but it also varies depending on the specific environment. Its melting point and boiling point are closely related to the intermolecular force and relative molecular weight. Generally speaking, those with strong intermolecular force and high relative molecular weight have higher melting points and boiling points.
Chemical properties, hydroxyl groups are active. First, esterification can occur. When encountering carboxylic acids or their derivatives, under suitable catalysts and conditions, the hydrogen atom in the hydroxyl group combines with the hydroxyl group in the carboxyl group to form water, and the two are connected to form esters. This reaction is commonly used in organic synthesis and can build complex compound structures. Second, it can be oxidized. Under the action of suitable oxidants, the hydroxyl group can be converted into an aldehyde group or even a carboxyl group. This oxidation process provides a variety of paths for organic synthesis.
Furthermore, the pyridine ring also gives the compound special properties. The pyridine ring has aromatic properties and a special electron cloud distribution, which enables it to undergo electrophilic substitution reactions. Due to the influence of fluorine atoms and hydroxymethyl groups, the substitution reaction check point is preferred. The fluorine atom is electronegative and has an electron-absorbing induction effect, which reduces the electron cloud density of the pyridine ring. The electrophilic substitution reaction activity may be weaker than that of the pyridine itself, and the substitution check point is mostly in the interposition of the pyridine ring.
In addition, the compound can also participate in metal-catalyzed reactions. Pyridine cyclic nitrogen atoms can coordinate with metal ions to form stable complexes, which act as ligands in catalytic reactions to change the electronic properties and spatial structure of metal catalysts, thereby affecting the reactivity and selectivity.
In summary, 5-fluoro-2-hydroxymethylpyridine shows diverse chemical properties and application potential in organic synthesis, catalysis and other fields due to its unique structure.

It is difficult to determine the price range of 5-fluoro-2-hydroxymethylpyridine in the market. The price of 5-fluoro-2-hydroxymethylpyridine often varies due to many factors, such as material source, quality specifications, market supply and demand, and the amount of purchase.
In the past, the source of materials has a great influence on its price. If it is derived from rare or difficult-to-harvest raw materials, its price will be high; if the raw materials are easily available, the price will be flat. And quality specifications are also the key. Those with high purity are more expensive, and those with low purity are less expensive.
The supply and demand relationship of market conditions also affects its price. If there are many seekers and there are few suppliers, the price will rise; if the supply exceeds the demand, the price will fall. Furthermore, the amount of purchase also has an impact. Bulk buyers can often get preferential prices.
Because there is no detailed data, it is difficult to accurately say the price. However, you can go to the chemical raw material trading platform, chemical suppliers for details, or check industry reports, market surveys, and almost get a more accurate price range.