5-Fluoro-2,3-diaminopyridine

5-Hydroxy-2,3-dihydroxyacetophenone, this substance has not been specially recorded in the scope of "Tiangong Kaiwu", but it is deduced from the ancient knowledge of pharmacy and technology, or has the following uses.
In the field of pharmacy, hydroxyl, dihydroxyl and other structures endow it with certain chemical activity. Ancient books often say that "all medicines are based on sex and taste", and those containing such structures may have the effect of clearing heat and reducing fire. Looking at traditional herbs, many plants and trees containing hydroxyl compounds are often used in heat-clearing prescriptions. Such as Rehmannia, rich in hydroxyl groups, have the power of clearing heat and cooling blood. 5-Hydroxy-2,3-dihydroxyacetophenone may be able to participate in biochemical reactions in the body and regulate the body's heat syndrome by virtue of its structural characteristics.
In terms of process, because there are multiple hydroxyl groups in its structure, it can be complexed with metal ions. In ancient dyeing processes, certain compounds are often used to interact with metal ions to achieve color fixing purposes. Such as madder dyeing, metal ions are often complexed with madder pigments by means of mordant. 5-Hydroxy-2,3-dihydroxyacetophenone may be used as a natural complexing agent in similar processes to assist in the binding of dyes to fabrics and improve dyeing fastness.
In addition to fragrance blending, this compound may produce a special odor due to its unique structure. The ancient fragrance, focusing on the natural ingredients of the fragrance. Some substances with special hydroxyl structure can emit a light aroma. 5-Hydroxy-2,3-Dihydroxyacetophenone or can be refined and prepared into the fragrance, adding a unique charm to the aroma.

5-Hydroxy-2,3-dioxyglutaric acid, also known as oxaloacetic acid, is a kind of organic acid. Its physical properties are quite characteristic, it is a white crystal, and it is solid at room temperature and pressure. This substance exhibits a certain solubility in water and can be moderately dissolved. In organic solvents, such as ethanol and ether, it also has a certain solubility, but the degree of solubility varies.
The melting point of oxaloacetic acid is in a specific range, about 161-162 ° C. At this temperature, it will transform from solid to liquid. During the heating process, if the temperature continues to rise, beyond a certain limit, a decomposition reaction will occur, and its chemical structure will be destroyed to form other substances.
Furthermore, oxaloacetic acid has a certain degree of acidity. Because its molecular structure contains a carboxyl group, this functional group gives it acidic characteristics. In chemical reactions, it can neutralize with bases to generate corresponding salts and water. In living organisms, oxaloacetic acid plays a crucial role in the key metabolic pathway of the tricarboxylic acid cycle, participating in many biochemical reactions and is of great significance for maintaining the normal physiological functions of organisms.

The chemical properties of 5-hydroxy-2,3-dihydroxyacetophenone are still stable. This substance contains special functional groups, and the hydroxyl group is connected to the benzene ring, giving it specific chemical activity.
However, its stability is also affected by various factors. In normal environments, without extreme conditions such as significant oxidation, acid-base erosion, or high temperature, its molecular structure can be relatively stable. Hydroxyl groups have a certain hydrophilicity, so in humid environments or in contact with water, there may be weak hydrolysis, but this process is usually slow.
In case of strong oxidants, such as permanganate, dichromate, etc., because of their active hydroxyl groups, or can be oxidized, resulting in changes in molecular structure and impaired stability. In acidic or alkaline media, depending on the strength of its pH, or the occurrence of acid-base reactions, its stability will also be affected. Acids can catalyze some condensation or substitution reactions, while bases may cause hydroxyl ionization, which in turn triggers a series of reactions.
But in general, if there are no special external factors interfering, 5-hydroxy-2,3-dihydroxyacetophenone can maintain a certain degree of stability, and under moderate storage conditions, its chemical structure and properties can be maintained for a certain period of time.

There are several common methods for the synthesis of 5-alkyne-2,3-dihydroxypyridine:
One is a compound containing a pyridine structure as the starting material. If an appropriate pyridine derivative is selected, an alkynyl group and a hydroxyl group are introduced at a specific position in the pyridine ring. First, pyridine is used as the substrate, and under the action of a base, a nucleophilic substitution reaction is used to replace the halogen atom on the pyridine ring with an alkynyl negative ion to form a pyridine derivative containing an alkynyl group. This process requires the selection of a suitable base, such as sodium hydride, and the choice of reaction solvent is also very critical. Aprotonic solvents such as anhydrous tetrahydrofuran are often used to ensure the smooth progress of the reaction. Subsequently, hydroxyl groups are introduced at specific positions of the pyridine ring by means of oxidation reactions. Oxidants such as m-chloroperoxybenzoic acid can be used to oxidize specific carbon-hydrogen bonds on the pyridine ring under mild reaction conditions, thereby generating hydroxyl groups.
The second is to synthesize the pyridine ring in a way that builds the pyridine ring. Pyridine rings can be constructed by condensation reactions using multi-component reactions, such as acetylene derivatives, carbonyl-containing compounds, and ammonia sources. During this process, controlling the temperature of the reaction, the ratio of reactants, and the reaction time is extremely important for the selectivity of the target product. For example, the ratio of the reactants is precisely adjusted so that the reaction tends to form 5-alkynyl-2,3-dihydroxypyridine. During the reaction, the temperature may need to be maintained in a certain range, or the reaction may be initiated at a low temperature, and then slowly heated to a suitable temperature to promote the smooth construction of the pyridine ring and the correct introduction of each functional group.
Furthermore, it can be achieved by the reaction of organometallic reagents. For example, a metal-catalyzed coupling reaction between an alkyne-based fund reagent and a pyridine halide is used to form a pyridine intermediate containing alkynyl groups. Commonly used metal catalysts such as palladium catalysts, such as tetra (triphenylphosphine) palladium, etc. Then, through the subsequent functional group conversion reaction, the hydroxyl group is introduced into the pyridine ring. This step can be achieved by nucleophilic substitution, oxidation and other reactions. Attention should be paid to the optimization of the reaction conditions to avoid affecting the introduced alkynyl groups.
All these methods have their own advantages and disadvantages. In actual synthesis, the most suitable synthesis path should be selected according to the specific experimental conditions, the availability of raw materials and the purity requirements of the target product.

I look at your question, but I am inquiring about the price of 5-hydroxy- 2,3-dioxo-pyridine in the market. However, the price of this product often varies for many reasons.
First, its purity affects the price. If the purity is high, it is close to analytical purity or higher, and it is suitable for precise needs such as scientific research experiments, its price will be high. And those with slightly lower purity, or for general industrial use, the price will be slightly lower.
Second, the amount purchased is related to the price. If a large number of purchases are made, the merchant may give a discount due to economies of scale, and the unit price will be reduced. If only a small amount is purchased, it is used for laboratory primary research, etc., the unit price may be high.
Third, market supply and demand also affect its price. If there is a large increase in demand at a certain time and the supply is limited, the price will rise; conversely, if the supply is sufficient and the demand is stable, the price may stabilize or drop.
In the current market, the price of 5-hydroxy- 2,3-dioxo pyridine, if it is ordinary purity industrial grade, is hundreds of yuan per kilogram or more. If it is high-purity scientific research grade, the price per gram may reach tens of yuan or even higher. However, this is only an approximate number. The market situation is ever-changing. The actual price should be consulted with chemical raw material suppliers, reagent sellers, etc., and it also fluctuates depending on the region and season.