5-fluoro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid

5-Fluoro-1H-pyrrolo [2,3-b] pyridine-2-carboxylic acid, this is the English name of an organic compound. According to the organic chemical nomenclature, its chemical structure can be deduced.
"pyrrolo [2,3-b] pyridine", showing that the core structure of the compound is a pyrrolido [2,3-b] pyridine ring system. This ring system is formed by fusing a pyrrole ring with a pyridine ring, and the 2 and 3 positions of the pyrrole ring are connected to the pyridine ring.
"5-fluoro" indicates the introduction of fluorine atoms at the 5 position of the fused ring system. Fluorine atoms have unique electronic effects that affect the physical, chemical and biological activities of compounds.
"2-carboxylic acid", shown in the 2 position of the fused ring structure with a carboxylic group (-COOH). The carboxylic group is acidic and can participate in many chemical reactions, such as salt formation, esterification, etc.
In summary, the chemical structure of 5-fluoro-1H-pyrrolo [2,3-b] pyridine-2-carboxylic acid is an organic compound with pyrrolio [2,3-b] pyridine as the parent nucleus, with fluorine atom substitution at the 5th position and carboxylic group at the 2nd position. This structure endows the compound with specific chemical properties and potential application value, and may have important uses in fields such as medicinal chemistry and materials science.

5 - fluoro - 1H - pyrrolo [2,3 - b] pyridine - 2 - carboxylic acid, that is, 5 - fluoro - 1H - pyrrolido [2,3 - b] pyridine - 2 - carboxylic acid, this is an organic compound. Its main physical properties are as follows:
Looking at its properties, it is mostly solid under normal conditions, but its specific appearance varies depending on purity and crystallization, or it is white to off-white powder, or crystalline solid, which is a common appearance of organic compounds.
The melting point is discussed, and its melting point is within a specific range due to the characteristics of the intermolecular force and structure of the compound. It is rare to obtain detailed experimental data, but according to the properties of similar fluorine-containing heterocyclic carboxylic acid compounds, the melting point may be between 150 ° C and 250 ° C. The presence of fluorine atoms in the genome molecule can enhance the intermolecular force, and the heterocyclic and carboxyl groups also have a significant impact on the melting point.
In terms of solubility, the solubility of this compound in water is limited. Although there are carboxyl groups in the molecule that can form hydrogen bonds with water, the heterocyclic structure of fluoropyrrole-pyridine has strong hydrophobicity, resulting in poor overall water solubility. In organic solvents, such as common N, N-dimethylformamide (DMF), dichloromethane, ethanol, etc., their solubility may be different. In DMF, because it is a strong polar aprotic solvent, it can form a good interaction with the compound, and the solubility is relatively high; in weak polar organic solvents such as dichloromethane, the solubility may be slightly lower, but there is still a certain solubility; in ethanol, because ethanol has both polarity and certain lipophilicity, the solubility will also depend on the specific interaction between molecules.
In addition, the density, boiling point and other properties of the compound are also restricted by its molecular structure. Density may vary depending on the degree of molecular packing compactness, but in the absence of exact data, it can be inferred that its density is slightly higher than that of water. Because the molecule contains fluorine atoms and heterocyclic structures, the ratio of molecular mass to volume is relatively large. Boiling point is due to complex intermolecular forces, or in a higher temperature range, but the specific value needs to be accurately determined by experiments.
In conclusion, the physical properties of 5-fluoro-1H-pyrrolido [2,3-b] pyridine-2-carboxylic acids are closely related to their structures, and different physical properties are of great significance in the fields of organic synthesis and drug development, which can provide a key basis for their separation, purification and application.

5 - fluoro - 1H - pyrrolo [2,3 - b] pyridine - 2 - carboxylic acid is an important compound in the field of organic synthesis. There are many common synthesis methods, which are described as follows:
First, the method of using nitrogen-containing heterocyclic compounds as starting materials. Appropriate pyridine derivatives can be taken first and halogenated to introduce fluorine atoms at specific positions in the pyridine ring. This step requires careful selection of halogenation reagents and reaction conditions to ensure precise positioning of fluorine atoms. Then, through a series of condensation and cyclization reactions, the parent nuclear structure of pyrrolido-pyridine is constructed. In the condensation reaction, the ratio of reactants, reaction temperature and time are all key factors, which have a significant impact on the yield and purity of the product. In the cyclization step, specific catalysts may be required to efficiently form the target ring system.
Second, the synthesis path catalyzed by transition metals is adopted. Transition metals such as palladium and copper are often used as catalysts to promote coupling reactions between fluorine-containing and nitrogen-containing substrates. This path requires careful consideration of the type of catalyst and the selection of ligands, because different combinations have a significant impact on the reaction activity and selectivity. For example, choosing a suitable phosphine ligand with palladium catalyst can effectively improve the reaction efficiency and product selectivity. The types of solvents and bases in the reaction system cannot be ignored. Suitable solvents can enhance the solubility of the substrate and catalyst, while suitable bases can help to regulate the acid-base environment of the reaction and promote the smooth progress of the reaction.
Third, structural modification methods based on natural products or existing compounds. If natural products or known compounds with similar structures can be found, they can be modified in a targeted manner. Through chemical means, such as substitution, oxidation, reduction, etc., fluorine atoms and carboxyl groups are gradually introduced to achieve the conversion to the target compound. This method requires in-depth understanding of the structure and reactivity of the starting compound before a reasonable modification route can be designed.
The above synthesis methods have their own advantages and disadvantages. In practical application, it is necessary to comprehensively consider the availability of raw materials, cost, difficulty in controlling reaction conditions, and the purity and yield of the target product to select the most suitable synthesis strategy.

5-Fluoro-1H-pyrrolo [2,3-b] pyridine-2-carboxylic acid, or 5-fluoro-1H-pyrrolo [2,3-b] pyridine-2-carboxylic acid in Chinese, has applications in medicine, materials and other fields.
In the field of medicine, this compound has attracted much attention in the development of new drugs due to its unique chemical structure and biological activity. It may be used as a key intermediate for the synthesis of compounds with specific pharmacological activities. For example, for some disease-related targets, researchers can explore the possibility of developing new therapeutic drugs by modifying their structures. The nitrogen-containing heterocyclic structure and fluorine atom may endow the compound with specific lipophilicity, electronic effects and biological activity, which will affect the interaction between the drug and the target, and then is expected to improve the drug efficacy, pharmacokinetic properties and safety.
In the field of materials, this compound may have unique optoelectronic properties. The nitrogen-containing heterocyclic structure can provide a rich electron conjugation system. Fluorine atoms introduce or change the molecular charge distribution and electron cloud density, which in turn affects the optical and electrical properties of the material. For example, in organic optoelectronic materials, it may be used as a building unit to participate in the preparation of organic Light Emitting Diodes (OLEDs), organic solar cells and other materials, providing a new way to develop new materials with high performance, low cost and easy processing. In addition, in the field of chemical synthesis, it can be used as a multifunctional synthesizer to participate in various organic reactions, build complex and diverse compounds, and contribute to the development of organic synthetic chemistry, helping researchers expand the boundaries of synthetic chemistry and prepare more compounds with potential application value.

5-Fluoro-1H-pyrrolo [2,3-b] pyridine-2-carboxylic acid, namely 5-fluoro-1H-pyrrolido [2,3-b] pyridine-2-carboxylic acid, is a class of organic compounds with high potential value in the field of pharmaceutical chemistry. Looking at its market prospects, it can be said that it is quite broad.
In the field of drug development, many studies have focused on compounds containing this structure, hoping to develop new and efficient therapeutic drugs through their unique chemical properties. For example, some innovative drug development projects for specific diseases are deeply exploring their pharmacological activities and therapeutic effects. Due to the particularity of its structure, it may have strong interactions with specific biological targets, opening up a new path for disease treatment.
In the field of organic synthesis, 5-fluoro-1H-pyrrolido [2,3-b] pyridine-2-carboxylic acid is also an important synthetic intermediate. It is often used as the starting material or key structural unit in the preparation of many fine chemicals and high value-added compounds. With the continuous improvement of organic synthesis technology, the demand for this compound may grow steadily. The optimization and innovation of synthetic methods are also the focus of academic and industrial attention to improve its synthesis efficiency and purity, and reduce production costs.
However, its market development also faces some challenges. First, the complexity of the synthesis process results in high production costs, restricting its large-scale production and wide application. Second, strict drug regulatory policies require the compound and its derivatives to go through a long and complicated approval process, increasing R & D cycles and costs.
Overall, although 5-fluoro-1H-pyrrolido [2,3-b] pyridine-2-carboxylic acid has considerable market potential, in order to fully tap this potential, researchers and industry personnel need to work together in synthetic technology innovation, cost control and regulatory compliance to promote the stable development of its market.