5-Cyano-pyridine-2-carboxylic acid methyl ester

Methyl 5-cyano-pyridine-2-carboxylate. This is an organic compound. It may be a white to pale yellow crystalline powder with specific chemical properties.
From a structural point of view, the molecule contains a cyanoyl group (-CN), a pyridine ring, and a functional group of methyl carboxylate (-COOCH 😉). The cyanyl group is highly active and can participate in various chemical reactions, such as hydrolysis to form carboxyl groups, or reduction to amino groups. The pyridine ring gives the molecule certain aromatic and basic properties. Due to the presence of nitrogen atoms, it can form salts with acids and can also play a role in nucleophilic or electrophilic substitution reactions. The methyl carboxylate functional group is relatively stable, but under certain conditions, such as acid or base-catalyzed hydrolysis reactions, it can be converted into carboxylic acids.
Its physical properties, such as melting point, boiling point, solubility, etc., are affected by intermolecular forces. Due to the polarity of cyano and ester groups, the compound may have a certain solubility in polar solvents such as methanol, ethanol, and acetone, but in non-polar solvents such as n-hexane and toluene.
Chemically, in addition to the hydrolysis and reduction reactions mentioned above, it can also participate in substitution reactions with nucleophiles. The hydrogen atom on the pyridine ring can be replaced by other groups under appropriate conditions to expand the chemical derivativeness of the compound. Methyl 5-cyano-pyridine-2-carboxylate has rich chemical properties and is an important intermediate in the field of organic synthesis. It can construct complex organic molecules through various reactions.

Methyl 5-cyano-pyridine-2-carboxylate has a wide range of uses. In the field of medicinal chemistry, it is often a key intermediate for the synthesis of drugs. Due to its special chemical structure, it can undergo many chemical reactions to construct complex drug molecules to develop new therapeutic drugs and fight various diseases.
In the field of materials science, it also has important functions. Or it can participate in the creation of special materials, such as materials with unique optical and electrical properties. Through its participation in polymerization reactions or other chemical processes, the materials may have outstanding performance in the field of optoelectronics and can be used to manufacture Light Emitting Diodes, sensors and other devices.
Furthermore, in the field of organic synthetic chemistry, it is an important building block for organic synthesis. Chemists use its active groups to ingeniously design reaction paths to realize the construction of complex organic molecules, expand the variety and structural diversity of organic compounds, and promote the progress and development of organic chemistry. Its applications in different fields are constantly being explored and expanded, providing key support for many scientific research and industrial production.

The synthesis method of methyl 5-cyano-pyridine-2-carboxylate often follows several paths. First, pyridine compounds are used as starting materials. If 2-methyl-5-cyanopyridine is selected, the methyl group can be converted into carboxyl group through oxidation reaction. Commonly used oxidizing agents include potassium permanganate, potassium dichromate and other strong oxidizing agents. Under suitable reaction conditions, such as in a specific solvent, controlling temperature and reaction time, this step can be realized. Subsequently, the obtained 5-cyano-pyridine-2-carboxylic acid is esterified with methanol under the action of a catalyst. This catalyst is mostly concentrated sulfuric acid, or p-toluenesulfonic acid, etc. During the reaction, attention should be paid to the reaction temperature and material ratio to promote the esterification reaction to proceed smoothly, so as to obtain methyl 5-cyano-pyridine-2-carboxylate.
Second, 2-chloro-5-cyanopyridine can be started from 2-chloro-5-cyanopyridine. First, 2-chloro-5-cyanopyridine reacts with nucleophiles such as sodium methoxide to introduce methoxy groups to form corresponding methoxy pyridine derivatives. Then, hydrolysis of cyano groups into carboxyl groups and esterification can also achieve the synthesis of the target product. The hydrolysis step, or catalyzed by acid or base, is a reasonable choice according to the specific reaction conditions and subsequent treatment.
Third, 5-cyano-2-halopyridine is used as the starting material, and carbon monoxide and methanol are synthesized by carbonylation under a suitable catalyst system. In this process, the choice of catalyst is crucial, such as palladium-based catalysts, with specific ligands, at specific reaction pressures and temperatures, to promote the carbonylation reaction and build a carboxyl methyl ester structure, resulting in 5-cyano-pyridine-2-carboxylic acid methyl ester. Each method has its advantages and disadvantages. In actual synthesis, it is necessary to carefully weigh and choose according to various factors such as the availability of raw materials, cost, and difficulty of reaction.

5-Cyanopyridine-2-carboxylic acid methyl ester, the price of this product in the market is geometric, and it is difficult to judge. The change in its price depends on many reasons.
As far as the raw materials are concerned, if the raw materials required for the production of 5-cyanopyridine-2-carboxylic acid methyl ester are changed in the origin and output, or due to the weather and geographical conditions, the raw materials are rare, the cost will rise, and its price in the market will also increase. If a key raw material depends on the sudden disaster in the origin and the output will drop sharply, the price of this chemical will be affected by it.
The simplicity of the process is also the main reason. If the preparation method is complicated, requires multiple processes, and the operation of each step is fine, the requirements for appliances and manpower are very high, and the cost is very high, and the price is not cheap. On the contrary, if the process is refined and the process is simple, the cost is controllable, and the price may be slightly lower.
Market supply and demand also affect its price. If for a while, the demand for 5-cyanopyridine-2-carboxylate methyl ester in many industries increases sharply, such as medicine, chemical industry and other industries are competing for it, and the supply is difficult to respond in time, and the price will rise. However, if the demand is sluggish and the supply exceeds the demand, the price will drop.
Furthermore, the price varies depending on the place where you are located. In a place with abundant materials and convenient transportation, the price may be slightly flat due to smooth logistics and easy access to resources; if it is remote, transportation is difficult, and various costs are superimposed, the price will be high.
From this perspective, in order to know the exact market price of 5-cyanopyridine-2-carboxylic acid methyl ester, it is necessary to carefully consider the raw materials, process, supply and demand, and regional affairs, and comprehensively consider, in order to obtain a more accurate price.

Methyl 5-cyano-pyridine-2-carboxylate is an important organic compound. During storage and transportation, many matters must be paid attention to.
First words storage. This compound should be placed in a cool, dry and well-ventilated place. If it is covered in high temperature, humidity, or cause changes in properties, or even chemical reactions and deterioration. High temperature can promote its molecular activity to increase, causing reactions such as decomposition or polymerization; in a humid environment, moisture may participate in the reaction, affecting its purity and stability.
Furthermore, the storage place should be away from fire and heat sources, because it has certain chemical activity, in case of open fire, hot topic or danger. It should also be stored separately from oxidizing agents, acids, alkalis, etc. These substances can chemically react with methyl 5-cyano-pyridine-2-carboxylate, causing safety accidents.
As for transportation, it is necessary to ensure that the packaging is complete and sealed. The transportation process must be protected from sun exposure, rain and high temperature. The transportation vehicle should also be equipped with the corresponding variety and quantity of fire fighting equipment and leakage emergency treatment equipment. When handling, be sure to pack and unload lightly to prevent damage to the packaging and containers. Damaged packaging can cause it to leak, pollute the environment, and cause dangerous reactions. In conclusion, methyl 5-cyano-pyridine-2-carboxylate has strict requirements in terms of environmental conditions, material isolation, and packaging protection during storage and transportation, so as to ensure its quality and transportation safety.