5 Cyano 2 Pyridinecarboxylicacid
pyridine pyrrole pyrazine piperidine piperazine

5-Cyano-2-pyridinecarboxylicacid

    Specifications

    HS Code

    308578

    Name 5-Cyano-2-pyridinecarboxylic acid
    Molecular Formula C7H4N2O2
    Molecular Weight 148.12 g/mol
    Appearance Solid (usually powder or crystalline form)
    Melting Point 240 - 244 °C
    Solubility In Water Poorly soluble
    Solubility In Organic Solvents Soluble in some polar organic solvents like DMSO
    Pka Value ~3.4 (estimated for carboxylic acid group)
    Stability Stable under normal conditions, but reactive towards strong acids and bases
    Odor Odorless or faint odor
    Cas Number 4040-72-0

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    General Information
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    Frequently Asked Questions

    As a leading 5-Cyano-2-pyridinecarboxylicacid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What is the chemistry of 5-Cyano-2-pyridinecarboxylic acid?
    5-Cyano-2-pyridinecarboxylic acid is an organic compound whose molecule contains a cyanide group (-CN) and a carboxyl group (-COOH), which are connected to the pyridine ring. The chemical properties of these two are active, so that the compound exhibits unique reaction characteristics.
    As far as carboxyl groups are concerned, they are acidic and can neutralize with bases to form corresponding carboxylic salts and water. For example, when reacted with sodium hydroxide, 5-cyano-2-pyridinecarboxylate sodium and water will be formed. And carboxyl groups can participate in esterification reactions. Under acid catalysis, they react with alcohols to form esters and water.
    Cyanyl groups are also active and can undergo hydrolysis reactions. Under acidic conditions, it is gradually hydrolyzed into amides, and then hydrolyzed into carboxylic acids; under alkaline conditions, carboxylic salts and ammonia are hydrolyzed. Cyanyl groups can also participate in nucleophilic addition reactions, because their carbon atoms are electrophilic and vulnerable to nucleophilic reagents.
    5-cyano-2-pyridinecarboxylic acid is widely used in the field of organic synthesis because it contains two types of active groups. It can be used as a key intermediate for the preparation of a variety of nitrogen-containing heterocyclic compounds, which have important applications in many fields such as medicine, pesticides and materials science.
    What are the synthetic methods of 5-Cyano-2-pyridinecarboxylic acid?
    The synthesis method of 5-cyano-2-pyridinecarboxylic acid has been known for a long time. There are many methods, all of which are exquisite, and I will describe them in detail today.
    One of the methods is to start with pyridine derivatives. First take a suitable pyridine substrate and introduce a cyanyl group at a specific position. This step requires precise control of the reaction conditions. Often cyanide reagents, such as potassium cyanide, are used in the presence of suitable solvents and catalysts. The cyanide group is connected to the pyridine ring through substitution reaction. Then, carboxylation is carried out at another position. The method of carboxylation can use reagents such as carbon dioxide to introduce carboxyl groups under the action of specific bases and metal catalysts, and finally obtain 5-cyano-2-pyridinecarboxylic acid.
    The second method also starts from pyridine-related raw materials. First construct a pyridine ring, and reserve functional groups that can be converted into cyano and carboxyl groups on the ring. If a halogen atom is introduced first, and then a cyanyl group is substituted for the halogen atom, this substitution reaction must pay attention to the activity of the reagent and the reaction temperature. Then, through specific oxidation or other conversion methods, another functional group is converted into a carboxyl group to obtain the target product.
    The third method uses the strategy of organic synthesis. Based on other nitrogenous and carbon-containing compounds, the pyridine ring is gradually spliced. During the splicing process, cyanyl groups and carboxyl groups are introduced synchronously or sequentially. This process requires a good understanding of various reaction mechanisms, such as nucleophilic addition and elimination reactions, and careful regulation of the reaction sequence and conditions, in order to achieve the purpose of synthesis. Each method has its own advantages and disadvantages, or the raw materials are easy to obtain and the steps are cumbersome, or the reaction conditions are harsh but the yield is quite high. When synthesizing, it is necessary to weigh the advantages and disadvantages according to the actual situation, and choose the best method to obtain pure 5-cyano-2-pyridinecarboxylic acid.
    5-Cyano-2-pyridinecarboxylic acid is mainly used in which areas
    5-Cyano-2-pyridinecarboxylic acid, this substance has a wide range of uses. In the field of medicine, it is often a key intermediate for the synthesis of drugs. Due to its special chemical structure, it can participate in many reactions and help create drugs for the treatment of specific diseases. For example, for some difficult diseases, after ingeniously designing reactions, using it as a starting material, complex drug molecular structures are gradually constructed, bringing hope for recovery to patients.
    In the field of materials science, it is also of great value. It can be used to prepare functional materials, which can be treated by specific processes to obtain unique properties. For example, it can be used to make new photoelectric materials. Because of its structural characteristics, it can affect the photoelectric conversion efficiency of materials. It plays a role in photoelectric devices such as Light Emitting Diodes, solar cells, etc., and promotes related technological progress.
    In the field of organic synthesis, it is even more favored. As an organic synthesis block, it can react with a variety of reagents to build a diverse and complex organic molecular structure. Chemists can design exquisite synthesis routes according to their reactivity and check points, prepare organic compounds with specific functions and structures, expand the chemical boundaries of organic synthesis, and lay the foundation for chemical research and related industrial development. The application of this compound in the above fields has continuously promoted technological innovation and development in various fields, demonstrating a unique and important position.
    What is the market price of 5-Cyano-2-pyridinecarboxylic acid?
    5-Cyano-2-pyridinecarboxylic acid, the price of this product in the market is difficult to determine. The price of 5-cyano-2-pyridinecarboxylic acid often varies due to many reasons, such as the abundance of the production source, the difficulty of preparation, and the amount of need are all important factors.
    Looking at the market conditions of chemical materials in the past, if the production source is wide and the preparation is easy, its price is low; if the production source is narrow and the preparation is complex, or if there are many people who need it, the price will be high. The preparation of 5-cyano-2-pyridinecarboxylic acid involves a multi-step reaction, and the materials and processes used are all exquisite, which may cause its cost to fluctuate.
    And the chemical market is changing, and the trend of supply and demand is different in an instant. If there is a large increase in demand for a while, and production cannot respond, the price will rise; on the contrary, if the supply exceeds the demand, the price will decline. And the markets in different regions, due to transportation, taxation, etc., have different prices.
    Therefore, in order to determine the current market price of 5-cyano-2-pyridinecarboxylic acid, it is necessary to carefully investigate the market conditions of chemical raw material trading, consult the merchants specializing in this industry, or refer to the records of recent transactions, to obtain a more accurate price. However, there is no detailed information at this moment, and it is difficult to specify the specific price.
    What are the storage conditions for 5-Cyano-2-pyridinecarboxylic acid?
    5-Cyano-2-pyridinecarboxylic acid is an organic compound. Its storage requires specific conditions to maintain the stability of its chemical properties and avoid deterioration or danger.
    First pay attention to the ambient temperature of storage. This compound should be placed in a cool place, because high temperature can easily increase its chemical reactivity, or cause adverse changes such as decomposition and polymerization. The temperature should be controlled between 15 ° C and 25 ° C, so that its structure can be maintained stable.
    Second, humidity is also the key. Humid environment or cause it to absorb moisture, which affects purity and quality. Therefore, it should be stored in a dry place, and the relative humidity should be lower than 60%. A desiccant can be placed in the storage area to remove water vapor from the environment.
    Furthermore, 5-cyano-2-pyridinecarboxylic acid is sensitive to light. Light or photochemical reactions can damage its quality. Therefore, it must be stored in a dark place, such as in a brown bottle, or in a corner of the warehouse without light.
    In addition, this compound has certain chemical activity and cannot be stored with strong oxidants, strong acids, strong bases, etc. Due to contact with it, or a violent chemical reaction, heat, gas production, or even explosion should be generated. It should be placed separately from such substances, and the spacing should be appropriate to ensure safety.
    When storing, also pay attention to the integrity of the package. The packaging must be tight to prevent the intrusion of air, water vapor and impurities. If the packaging is damaged, it should be replaced in time to ensure that the compound is isolated from the outside world.
    Follow the above storage conditions to effectively protect the quality and stability of 5-cyano-2-pyridinecarboxylic acid and exert its due effectiveness in subsequent use.