5-Cyano-2-hydroxypyridine

5-Cyano-2-hydroxypyridine has a wide range of uses. In the field of medicinal chemistry, it is an important intermediate for the synthesis of many drugs. Due to its unique chemical structure, it has the potential to interact with biologically active molecules, and can participate in the construction of complex drug molecular structures, helping to create new drugs for the treatment of various diseases, such as antibacterial, anti-inflammatory, and anti-tumor drugs.
In the field of materials science, it has also emerged. It can be used as a key component in the construction of functional materials. With its special electronic properties and reactivity, it can modulate the optical and electrical properties of materials, and is expected to be applied to frontier materials such as organic Light Emitting Diodes and sensors.
In organic synthetic chemistry, it is a key building block. Chemists can build rich organic compounds through various organic reactions, such as nucleophilic substitution, electrophilic substitution, etc., according to their chemical activity check points, expand the diversity of organic molecules, and contribute to the development of organic synthetic chemistry. Therefore, 5-cyano-2-hydroxypyridine plays a pivotal role in many fields, promoting scientific research and technological innovation in various fields.

5-Cyano-2-hydroxypyridine is an important compound in organic chemistry. It has many unique physical properties and has attracted much attention from chemists.
This compound is mostly solid at room temperature, with a fine texture and a white or nearly colorless color, like the purity of white snow. Its melting point is in a specific range, about [X] ° C. Under this temperature, it lies quietly. If it heats up to the melting point, it gradually turns into a flowing state, just like ice and snow melting and turning into a babbling trickle.
When it comes to solubility, 5-cyano-2-hydroxypyridine is quite soluble in polar organic solvents, such as methanol, ethanol, dimethyl sulfoxide, etc., just like a fish entering water and fusing seamlessly. However, in non-polar solvents, such as n-hexane and benzene, the solubility is poor, just like oil and water, and it is difficult to dissolve.
Looking at its density, it is heavier than water. If placed in water, such as a stone sinking abyss, it sinks slowly. Its smell is weak and specific, like a mysterious smell hidden behind the scenes, and it needs to be sniffed carefully to detect it.
The physical properties of 5-cyano-2-hydroxypyridine are of great significance in the fields of organic synthesis and drug development. Because of its solubility and stability, chemists can use it to construct complex organic molecules, just like skilled craftsmen use exquisite materials to build magnificent structures. In the process of drug development, its properties may affect the absorption, distribution and metabolism of drugs, providing a key foundation for the creation of high-efficiency new drugs.

The synthesis of 5-cyano-2-hydroxypyridine is an important research direction in the field of chemical synthesis. In the past, there were many ways.
One is to use 2-hydroxypyridine as the starting material. Shilling 2-hydroxypyridine reacts with appropriate cyanide reagents, such as potassium cyanide or trimethylsilyl cyanide, under suitable reaction conditions. Among these, the choice of solvent is extremely critical, and polar aprotic solvents, such as dimethylformamide (DMF) or dimethylsulfoxide (DMSO), are often used because they can promote the dissolution of the reagents and the progress of the reaction. The reaction temperature also needs to be precisely controlled, usually under heating conditions, between about 80 and 120 degrees Celsius, so that the reaction can smoothly occur nucleophilic substitution reaction, and a cyano group is introduced into the 5-position of the pyridine ring to obtain 5-cyano-2-hydroxypyridine.
Second, pyridine derivatives are also used as starters and obtained through a multi-step reaction. First, the pyridine ring is modified, such as introducing a suitable functional group at a specific position, and then halogenating at a specific position on the pyridine ring through a halogenation reaction. Afterwards, a cyanation reaction is used to replace the halogen atom with a cyanyl group. Finally, through the hydroxylation step, the hydroxyl group is introduced at the 2-position, and the target product is synthesized through a multi-step reaction.
Third, the method of organometallic catalysis has also attracted much attention. Transition metal catalysts, such as palladium and nickel, are used to catalyze the reaction between the substrate containing the pyridine structure and the cyanyl source and hydroxylation reagent. This method can achieve the synthesis of 5-cyano-2-hydroxypyridine under relatively mild conditions, and the selectivity is quite high, which can effectively reduce the occurrence of side reactions. However, the requirements for catalysts are very high, and the cost and recycling of catalysts are also factors to be considered.
The above methods for synthesizing 5-cyano-2-hydroxypyridine have their own advantages and disadvantages, and the most suitable one should be selected according to the actual needs and conditions.

I look at the price of the market, which is fickle, like the unpredictable situation. The market price of 5-cyano-2-hydroxypyridine is also difficult to hide. Due to the determination of prices, it is subject to many factors.
First, the abundance of raw materials is related to cost. If the raw materials required for its preparation are widely sourced and affordable, the price of 5-cyano-2-hydroxypyridine may be affordable; on the contrary, if the raw materials are scarce and difficult to obtain, the price will rise.
Second, the difficulty of preparation affects the output. If the preparation method is simple and efficient, the output can be increased, and the price may be stabilized; if the preparation process is complicated, time-consuming and laborious, and the cost must be high, the price will also rise accordingly.
Third, the supply and demand of the market affect the market. If the demand for this product is strong, but the supply is limited, and people compete to buy it, the price will rise; if the demand is low, and the supply exceeds the demand, the price may have a downward trend.
Also, the market competition is intense, and many manufacturers use various means, or reduce costs to compete for profits, or improve quality and price. And different regions have different prices, and the difference in transportation fees and taxes can make their prices different.
Therefore, in order to know the exact market price of 5-cyano-2-hydroxypyridine, it is necessary to carefully investigate the situation of raw materials, the method of preparation, the state of supply and demand, and the situation of local markets. After comprehensive consideration, a more accurate number can be obtained.

5-Cyano-2-hydroxypyridine is also an organic compound. Its storage conditions are related to the stability and quality of this substance, which cannot be ignored.
This substance should be stored in a cool place, protected from sunlight and light. Direct sunlight, or the breaking of chemical bonds in the compound, triggers reactions such as decomposition, which damage its chemical structure and properties. And if the temperature is too high, it can also accelerate the thermal movement of molecules, enhance the reaction activity, or cause deterioration. Therefore, choosing a cool place can reduce the risk of changes caused by temperature and light.
Furthermore, a dry environment is essential. Moisture is easy to make the compound absorb moisture, or cause reactions such as hydrolysis. If 5-cyano-2-hydroxypyridine absorbs moisture, the hydroxyl group or interacts with water, the cyano group may also change under the influence of water, thereby changing the purity and characteristics of the compound.
At the same time, sealed storage is indispensable. Sealing can isolate the outside air to prevent it from reacting with gases such as oxygen and carbon dioxide in the air. Oxygen or oxidizing, carbon dioxide may also interact with active groups in the compound to change its chemical composition.
In addition, the storage place should be kept away from fire sources, heat sources and incompatible substances. Fire sources and heat sources will increase the ambient temperature, as mentioned above, which is unfavorable to their stability. And incompatible substances, or react violently with them, cause danger.
In short, 5-cyano-2-hydroxypyridine should be stored in a cool, dry place, sealed, away from fire, heat and incompatible materials, so as to maintain its quality and stability for subsequent use.