(5-Chloropyridine)-2-Carboxylic acid ethyl ester

(5-Chloropyridine) - 2-carboxylate ethyl ester, this compound has a wide range of uses. In the field of pharmaceutical synthesis, it is often a key intermediate. Due to the structural characteristics of pyridine ring and chlorine atom, it can participate in various chemical reactions to construct molecular structures with specific pharmacological activities. For example, it can be combined with different reagents by nucleophilic substitution, coupling and other reactions to prepare drugs with antimalarial and antibacterial effects.
It also plays an important role in the creation of pesticides. It can be used as a starting material for the synthesis of new pesticides and chemically modified to generate compounds with high insecticidal, bactericidal or herbicidal activities. Because the structure of pyridine can endow pesticides with good biological activity and environmental compatibility, chlorine atoms can enhance their interaction with target biomolecules and improve drug efficacy.
In the field of materials science, (5-chloropyridine) -2-carboxylate ethyl ester may be used to synthesize special functional materials. By participating in polymerization reactions, etc., or by preparing polymer materials with specific optical, electrical or mechanical properties, it has made a name for itself in the fields of optoelectronics, sensors and so on.
To sum up, (5-chloropyridine) -2-carboxylate ethyl ester has important applications in many fields such as medicine, pesticides and materials due to its unique chemical structure, providing a key foundation for the development of related industries.

There are various ways to synthesize ethyl (5-chloropyridine) -2-carboxylic acid ester. The ancient classical Chinese text of this imitation of "Tiangong Kaiwu" is described as follows.
First, 5-chloropyridine-2-carboxylic acid and ethanol can be esterified under the catalysis of concentrated sulfuric acid. During this process, prepare an appropriate amount of refined 5-chloropyridine-2-carboxylic acid, put it in a clean flask, and add several times the amount of ethanol. Slowly drop concentrated sulfuric acid as a catalyst. Heat up to an appropriate degree, about 70-80 degrees Celsius, and stir continuously. During this time, the acid interacts with the alcohol to dehydrate and form esters. After the reaction is completed, the excess acid is neutralized in a saturated sodium bicarbonate solution, and the organic phase is separated by a separation funnel, dried with anhydrous magnesium sulfate, and the ethanol is removed by rotary evaporation to obtain (5-chloropyridine) -2-carboxylate ethyl ester.
Second, 5-chloropyridine-2-halo can also be used with diethyl malonate under alkaline conditions. Take 5-chloropyridine-2-halo first, and place it in a reaction kettle with diethyl malonate in an appropriate ratio, such as 1:1.2-1:1.5. Add alkaline reagents such as sodium alcohol, often sodium ethanol is preferred. At an appropriate temperature, such as 60-70 degrees Celsius, when the reaction number. The halogen atom of halopyridine is substituted with the active group of diethyl malonate. When the reaction is sufficient, the target product can be obtained through acidification, hydrolysis, decarboxylation and other steps. When acidified, slowly drop in dilute hydrochloric acid and adjust to a suitable pH. Hydrolysis needs to be warmed to 90-100 degrees Celsius for several hours. The decarboxylation reaction is completed at a higher temperature, resulting in (5-chloropyridine) -2-carboxylic acid ethyl ester.
Third, the reaction of 5-chloropyridine-2-formyl chloride with ethanol is also a method. The pure 5-chloropyridine-2-formyl chloride is prepared first, and it is added dropwise to the reaction vessel containing ethanol, and stirred moderately. This reaction is relatively rapid, at room temperature or slightly heated, about 30-40 degrees Celsius. The acyl group of formyl chloride is combined with the hydroxyl group of ethanol to form an ester and hydrogen chloride. After the reaction is completed, the hydrogen chloride is removed in a weak alkali solution, and pure (5-chloropyridine) -2-carboxylate ethyl ester is obtained through extraction, drying, distillation and other processes.

Ethyl (5-chloropyridine) -2-carboxylate is one of the organic compounds. Its physical properties are quite important and have applications in various fields of chemical industry.
Looking at its properties, it is mostly colorless to light yellow liquid under normal conditions, which is convenient for transfer and mixing during many process operations. Its odor has certain particularity. Although it is not strong and pungent, it is also recognizable. This odor characteristic has its significance in some processes that require fine sensory judgment.
When it comes to boiling point, it is about a certain temperature range. This temperature point is related to the setting of conditions for distillation, separation and other operations. The value of the boiling point can help the chemist to choose the appropriate temperature in the purification and other steps to ensure that the substance is vaporized at a specific temperature, separated from other substances, and obtained pure (5-chloropyridine) -2-carboxylate ethyl ester.
And the melting point also has a corresponding value. The characteristics of the melting point are crucial for the storage of substances and solid-state applications. Knowing the melting point can show the temperature range at which the substance is solid. When storing, the appropriate ambient temperature can be selected accordingly to avoid the change of state due to temperature discomfort and affect the quality.
Furthermore, its density is also an important physical property. Density values can help to calculate the mass of the substance at a specific volume, and are indispensable for precise control of ingredients and reaction proportions. When preparing mixtures containing this substance, density data can be used to ensure that the dosage is accurate, and the reaction proceeds as expected to achieve the required product quality and yield.
Solubility also cannot be ignored. (5-chloropyridine) -2-carboxylate ethyl ester has a certain solubility in organic solvents, such as common ethanol, ether, etc. This property makes it possible to build a homogeneous reaction system with these solvents in organic synthesis reactions, promoting the efficient progress of the reaction. However, in water, its solubility is poor, and this difference can be used for operations such as aqueous-organic phase separation, which helps to purify and refine the product.

I don't know what the market price of (5-chloropyridine) -2-carboxylate is. The price of these compounds often changes for many reasons.
First, the availability and price of raw materials have a great impact. If the raw materials required for the preparation of (5-chloropyridine) -2-carboxylate are scarce, or their prices fluctuate depending on the place of origin, season, and supply and demand, the price of finished products will also fluctuate.
Second, the difficulty of the preparation process is also related to the cost. If the process of synthesizing this compound is complicated, many steps are required, or expensive reagents and catalysts are used, or the reaction conditions are strict, and special equipment and technology are required, which will push up the production cost and then affect the market price.
Third, the supply and demand situation of the market is the key factor. If the compound is in high demand in the fields of medicine, pesticides, materials, etc., and the supply is limited, the price will tend to rise; conversely, if the market is saturated, the demand is weak, and the price may be reduced.
Fourth, the production scale of the manufacturer also plays a role. Large-scale production can often reduce the unit cost by virtue of the scale effect, which makes it more flexible in the market pricing, or can be sold at a relatively low price.
And the market environment, transportation costs, tax policies, etc. in different regions will make the price of (5-chloropyridine) -2-carboxylate vary. To know the exact market price, check the chemical product trading platform in detail, consult the relevant distributors or manufacturers to obtain the latest and accurate price information.

(5-Chloropyridine) - 2-carboxylate ethyl ester, this is an organic chemical. When storing and transporting, it is necessary to pay attention to many key matters.
When storing, the first choice of environment. It should be placed in a cool, dry and well-ventilated place. Because the compound is exposed to high temperature environment, or its chemical properties change, or even cause decomposition and deterioration. If the ambient humidity is too high, it may also promote moisture and affect the quality.
Furthermore, the storage place should be away from fire and heat sources. This compound may be flammable, and in case of open flames and hot topics, it may cause fire and endanger the safety of personnel and facilities.
At the same time, it needs to be stored separately from oxidants, acids, alkalis, etc., and must not be mixed. Due to its chemical activity, contact with the above substances, or severe chemical reaction, causing serious accidents such as explosion and leakage.
When transporting, the packaging must be tight and firm. Choose appropriate packaging materials to ensure that there is no damage or leakage during transportation. If the packaging is not good, the compound leaks, or the environment is polluted, and there is a risk of personal contact, which endangers health.
Transportation vehicles must also meet safety standards and be equipped with corresponding fire equipment and leakage emergency treatment equipment. In order to prevent emergencies during transportation, they can respond in time and reduce losses.
During transportation, careful loading and unloading should be done to avoid collisions and heavy pressure. Rough handling or packaging damage, causing compound leakage.
The escort personnel also need to undergo professional training, familiar with the characteristics of the compound and emergency treatment methods. Always pay attention during transportation, if there is any abnormality, dispose of it in time. In this way, the storage and transportation of (5-chloropyridine) -2-carboxylate ethyl ester are guaranteed to be safe.