5-Chloropyridine-2-carbonitrile

5-Chloropyridine-2-formonitrile is one of the organic compounds. Its physical and chemical properties are unique and it has a wide range of uses in the field of organic synthesis.
In terms of physical properties, 5-chloropyridine-2-formonitrile is often in a solid state, and its melting point and boiling point are different depending on the purity and environmental conditions. Generally speaking, the melting point can be accurately determined by experiments to provide evidence for the identification and purity of substances. It has different solubility in common organic solvents, and may have better solubility in polar organic solvents such as dimethylformamide (DMF) and dimethyl sulfoxide (DMSO). Due to the polarity of the nitrile group and the chlorine atom in the molecular structure, it can interact with polar solvents.
As for chemical properties, the chlorine atom in 5-chloropyridine-2-formonitrile is considerable. Because of its connection to the pyridine ring, the electronic effect of the pyridine ring makes the chlorine atom vulnerable to nucleophiles. Nucleophilic substitution reaction is one of its common reactions. For example, when interacting with nucleophilic reagents such as alkoxides and amines, chlorine atoms can be replaced by corresponding groups to form new pyridine derivatives. This is an important means to create novel compounds in medicinal chemistry and materials science.
Nitrile groups are also the key reaction check points of 5-chloropyridine-2-formonitrile. Nitrile groups can undergo hydrolysis reactions, and under acidic or basic conditions, they are gradually converted into carboxyl groups, amide groups, etc. Hydrolyzed in acidic media, often Mr. Chang forms amides, and then carboxylic acids; under alkaline conditions, the reaction process may be different, but they also follow a similar path. In addition, the nitrile group can participate in the reduction reaction, and can be converted into an amine group after being treated with a suitable reducing agent, providing a way for the introduction of amino functional groups in organic synthesis.
Furthermore, the pyridine ring of 5-chloropyridine-2-formonitrile is aromatic and can undergo electrophilic substitution reaction. The only reason is that due to the blunt effect of chlorine atoms and nitrile groups, the reaction conditions may be severe, and the reaction check point is affected by the localization effect of substituents, which mostly occurs at specific positions of pyridine rings. In conclusion, 5-chloropyridine-2-formonitrile is an important intermediate in many fields such as organic synthesis, drug research and development, and material preparation, which promotes the development of related science and technology due to its unique chemical properties.

The common methods for the synthesis of 5-chloropyridine-2-formonitrile are as follows:
First, 5-chloropyridine-2-formic acid is used as the starting material. This is a more commonly used method. First, 5-chloropyridine-2-formic acid is reacted with thionyl chloride to obtain 5-chloropyridine-2-formyl chloride. In this step, thionyl chloride is used as a chlorination reagent, and 5-chloropyridine-2-formyl chloride can be obtained when the reaction number is stirred at a suitable temperature, such as between 60 and 80 ° C. Then, the formyl chloride is reacted with sodium cyanide or potassium cyanide in an organic solvent such as N, N-dimethylformamide (DMF). The reaction temperature is controlled at about 80-100 ° C. After several reactions, 5-chloropyridine-2-formonitrile is obtained. This pathway step is relatively clear, but it is necessary to pay attention to the toxicity of the reagents used, and strictly follow the safety procedures when operating.
Second, start from 2-amino-5-chloropyridine. First, 2-amino-5-chloropyridine is diazotized. At a low temperature, such as 0-5 ° C, it is mixed with sodium nitrite and hydrochloric acid to form a diazonium salt. Subsequently, the diazonium salt is reacted with cyanide reagents such as cuprous cyanide in a specific solvent to obtain the target product 5-chloropyridine-2-formonitrile. This method requires strict control of the conditions of the diazonation reaction. Due to the active nature of diazonium salts, improper operation can easily lead to danger.
Third, pyridine is used as the starting material and prepared through a multi-step reaction. Pyridine is first chlorinated, and chlorine atoms are introduced to obtain 5-chloropyridine. Then 5-chloropyridine is reacted with suitable reagents, such as acetonitrile, under the action of strong base, and cyanyl groups are gradually introduced to prepare 5-chloropyridine-2-formonitrile. This route step is slightly complicated, but the raw material pyridine has a wide range of sources and may have advantages in cost. It is necessary to carefully control the reaction conditions of each step to obtain a higher yield.

5-Chloropyridine-2-formonitrile is a key intermediate in organic synthesis and has important uses in many fields.
In the field of medicinal chemistry, its position is crucial. It can be used as a raw material to synthesize a variety of drugs. For example, in the preparation of some antibacterial drugs, 5-chloropyridine-2-formonitrile can participate in the construction of the core structure of the drug. Through a series of chemical modifications, it can adjust the activity, solubility and binding ability of the drug molecule to the target, thereby enhancing the inhibitory or killing effect of the drug on specific bacteria.
In the field of pesticides, it also plays an indispensable role. It can be used as an important starting material for the synthesis of highly efficient pesticides. Through a series of chemical reactions, it is converted into compounds with specific insecticidal, bactericidal or herbicidal activities. Due to its unique chemical structure, it can endow pesticides with better biological activity and environmental adaptability, effectively improve the control effect of pesticides, and reduce the adverse effects on the environment.
In addition, in the field of materials science, 5-chloropyridine-2-formonitrile also shows potential value. It can participate in the synthesis of organic materials with special properties, such as some materials with photoelectric properties. By introducing it into the molecular structure of the material, the electron cloud distribution and energy level structure of the material can be changed, which in turn endows the material with unique optical and electrical properties, providing the possibility for the research and development of new optoelectronic devices.

5-Chloropyridine-2-formonitrile is a chemical substance. During storage and transportation, many matters need to be paid attention to.
First of all, storage, this substance should be placed in a cool, dry and well-ventilated place. Due to its nature or affected by temperature and humidity, if it is placed in a warm and humid place, it may cause deterioration and affect its quality and use. And should be stored separately from oxidants, acids, bases, etc., because these substances may react chemically with 5-chloropyridine-2-formonitrile, causing danger. At the same time, the storage place needs to have suitable equipment to contain leaks, so as to prevent accidental leakage from being handled in time and avoid greater harm.
As for transportation, it must be handled lightly when handling, and must not be operated brutally, so as to avoid damage to the packaging and leakage of 5-chloropyridine-2-formonitrile. Vehicles, boats and other tools used for transportation must be kept clean and dry, and there are no residual substances that can react with them. During transportation, close attention should also be paid to weather changes, and avoid transportation in bad weather, such as heavy rain and high temperature, to prevent severe changes in temperature and humidity from affecting its stability. And transport personnel should be familiar with its characteristics and emergency treatment methods. In case of an accident, they can respond quickly and properly to ensure the safety of personnel and the environment from serious pollution.

5-Chloropyridine-2-formonitrile is an important compound in organic chemistry. It has critical uses in many fields, such as the synthesis of medicines and pesticides. As for its market price, it is difficult to make a conclusion, considering that it is affected by multiple factors.
The first to bear the brunt is the cost of raw materials. The preparation of 5-chloropyridine-2-formonitrile requires specific starting materials. If these raw materials are scarce or the price fluctuates violently, the cost of 5-chloropyridine-2-formonitrile will be implicated. If the source of raw materials is abundant and the price is low, the price of the product is expected to decline; conversely, if the supply of raw materials is tight and the price rises, the price of the product will also increase.
Secondly, the difficulty of the preparation process also affects its price. If the preparation process is complicated, it needs to go through multiple steps, and each step requires strict conditions, and special catalysts or equipment are required, which will greatly increase the production cost, and the product price will be higher. On the contrary, if the process is simple and efficient, the cost is controllable, and the price may be close to the people.
Furthermore, the relationship between market supply and demand is also key. If the market demand for 5-chloropyridine-2-formonitrile is strong, but the supply is relatively insufficient, its price tends to rise; conversely, if the market is oversupplied, manufacturers may reduce prices in order to sell.
In addition, the macroeconomic environment, policies and regulations also have an impact. The economic situation is unstable, currency exchange rates fluctuate, and transportation costs may change, which will affect product prices. If policies and regulations tighten the requirements for environmental protection and safe production, and manufacturers increase their investment in compliance, it will also lead to price changes. Therefore, in order to know the exact market price of 5-chloropyridine-2-formonitrile, it is necessary to pay attention to the raw material market, production process progress, market supply and demand dynamics, and it is advisable to consult professional chemical product trading platforms, suppliers or industry experts to obtain more accurate price information.