5-chloro-3H-imidazo[4,5-b]pyridine-2-carboxylic acid

5-Chloro-3H-imidazolo [4,5-b] pyridine-2-carboxylic acid, this is an organic compound. In terms of physical properties, it may be solid under normal conditions, but the exact properties still need to be determined according to specific experimental conditions. Key physical parameters such as melting point and boiling point may vary in different literature due to different experimental measurement conditions.
In terms of chemical properties, the compound contains carboxyl groups, which are acidic and can neutralize with bases to form corresponding carboxylic salts. For example, when reacting with sodium hydroxide, the hydrogen in the carboxyl group is replaced by sodium ions to obtain the corresponding sodium salt and water.
The imidazolopyridine part in its structure has certain aromaticity and conjugated system, which endows the molecule with a unique electron cloud distribution, which affects its chemical activity and reaction check point. For example, in the electrophilic substitution reaction, due to the electron cloud density distribution characteristics of the conjugated system, specific positions are vulnerable to attack by electrophilic reagents.
In addition, chlorine atoms are attached to the molecular structure, and chlorine has an electron-absorbing induction effect, which changes the density of the surrounding electron cloud and affects the molecular reactivity and polarity. This compound may participate in the nucleophilic substitution reaction. The chlorine atom is replaced by other nucleophiles as a leaving group, and then a new carbon-heteroatomic bond or a carbon-carbon bond is constructed, which provides an important way for organic synthesis. In fields such as medicinal chemistry and materials science, it may be used to develop new drugs or functional materials based on its unique chemical properties.

The common synthesis methods of 5-chloro-3H-imidazolo [4,5-b] pyridine-2-carboxylic acid generally include the following.
First, a compound containing pyridine and imidazole structures is used as the starting material. First, a specific position on the pyridine ring is halogenated, and chlorine atoms are introduced, and then a carboxyl group is constructed by suitable reaction in the imidazolo-pyridine structure. This process requires fine control of the reaction conditions, such as temperature, reaction time, and ratio of reactants. Because the halogenation reaction is prone to side reactions, it is necessary to choose a halogenation reagent and reaction solvent with high efficiency and good selectivity to improve the yield of the target product.
Second, starting from simple pyridine derivatives. First, the imidazole-containing fragment is connected to the specific check point of the pyridine ring by nucleophilic substitution reaction, and then the carboxyl group is introduced through a series of reactions such as oxidation and hydrolysis. In this path, the conditional choice of nucleophilic substitution reaction is very important, and factors such as substrate activity, nucleophilic basicity and reaction solvent polarity need to be considered to ensure the smooth progress of the reaction and good selectivity.
Third, based on imidazole derivatives. Through a series of reactions, the pyridine ring is gradually established and chlorine atoms and carboxyl groups are introduced at the same time. This synthesis strategy requires an accurate understanding of the reactivity and reaction check point of the imidazole ring, and an appropriate protective group strategy is used to prevent unnecessary side reactions and ensure the selectivity and yield of each step of the reaction.
Each synthesis method has its own advantages and disadvantages, and it is necessary to weigh the appropriate synthesis path according to the actual situation, such as raw material availability, reaction cost, target product purity requirements, etc.

5-Chloro-3H-imidazolo [4,5-b] pyridine-2-carboxylic acid, which is used in the fields of medicine, pesticides and materials science.
In the field of medicine, due to its unique chemical structure, it can be used as a key intermediate to create new drugs. It can exhibit various biological activities such as antibacterial, anti-inflammatory and anti-tumor by acting on specific biological targets. In terms of antibacterial, it may interfere with the key metabolic pathways of bacteria or damage their cell structure to inhibit the growth and reproduction of bacteria; in terms of anti-tumor, it may block the proliferation signal transduction pathway of tumor cells and induce tumor cell apoptosis. < Br >
In the field of pesticides, it is also of great value. It can be developed into high-efficiency and low-toxicity pesticides, which can effectively control pests by affecting the nervous system or metabolic mechanism of insects, and have less harm to the environment, which is in line with the current needs of green agriculture development.
In the field of materials science, it can be used as a building unit of functional materials. Due to its special electronic structure and reactivity, it can be reasonably designed and modified to prepare materials with special optical, electrical or adsorption properties. For example, it can be used to prepare adsorption materials with high selectivity identification ability for specific substances, and is used in environmental monitoring and substance separation.
In summary, 5-chloro-3H-imidazolo [4,5-b] pyridine-2-carboxylic acids hold great potential for application in many fields, providing new opportunities and material bases for innovation and development in various fields.

5-Chloro-3H-imidazolo [4,5-b] pyridine-2-carboxylic acid, which is an organic compound in the field of fine chemicals. However, its market price is difficult to generalize, because many factors will affect its price.
First, the purity of the product is the key factor. High purity 5-chloro-3H-imidazolo [4,5-b] pyridine-2-carboxylic acid, because the preparation process is more complicated, the required technology and process are more exquisite, so the price is often higher. If the purity is above 99%, it may be able to obtain a higher price in the market due to meeting the strict needs of high-end pharmaceutical, electronics and other industries.
Second, the market supply and demand relationship determines the price. If there is a period of surge in demand for pharmaceutical R & D companies for specific drug synthesis, and the supply is relatively insufficient, the price will rise. On the contrary, if the market demand is weak and the supply is excessive, the price will fall.
Third, the cost of raw materials also has an impact. The price fluctuations of various starting materials required to prepare this compound will be transmitted to the final product. If raw materials are scarce or prices rise, the cost of 5-chloro-3H-imidazolo [4,5-b] pyridine-2-carboxylic acid will increase, and the price will also increase.
Fourth, production scale and process are also related to price. Large-scale production can reduce unit product cost and price or be more competitive with the help of scale effects. Advanced and efficient production processes can improve production efficiency and reduce energy consumption, which also has an impact on prices.
In summary, the market price of 5-chloro-3H-imidazolo [4,5-b] pyridine-2-carboxylic acid varies according to purity, supply and demand, raw material costs and production-related factors, and is in a dynamic state in the market. To know the exact price, it is necessary to carefully review the current market conditions and communicate with relevant suppliers.

5-Chloro-3H-imidazolo [4,5-b] pyridine-2-carboxylic acid, this is an organic compound. Looking at its physical properties, it is mostly solid under normal conditions, and its structure is stable due to the interaction of atoms in the molecule. Its melting point and boiling point values depend on the size of the intermolecular force. The molecule contains chlorine atoms, pyridine rings and imidazole rings, which cause it to have a specific polarity, which has a great influence on its solubility.
In common organic solvents, such as dichloromethane, N, N-dimethylformamide, the compound exhibits certain solubility due to its polar adaptation. However, in water, its solubility is limited due to its polarity not reaching a high degree of compatibility with water.
When it comes to appearance, it is mostly white to light yellow powder or crystalline, which is caused by the absorption and reflection characteristics of the molecule. In addition, the stability of the compound is good under conventional conditions. In case of strong acid, strong base or high temperature environment, due to the activity of chemical bonds in the molecule, it is easy to undergo chemical reactions and cause structural changes.