5-Chloro-3-methylpyridine-2-carboxylic acid

5-Bromo-3-methylpentene-2-acid is one of the organic compounds. It has unique chemical properties and has attracted much attention in the field of organic synthesis.
In this compound, the presence of bromine atoms endows it with specific reactivity. Bromine atoms have strong electronegativity, which can change the distribution of molecular electron clouds, making it easier to participate in nucleophilic substitution reactions. In this reaction, the nucleophilic test agent can attack the carbon atoms attached to bromine, and the bromine ion is separated as a leaving group, thereby generating new organic compounds.
Furthermore, the presence of double bonds also adds reactivity to the compound. Double bonds can participate in addition reactions, such as addition with hydrogen halide, halogen elements, etc., to introduce new functional groups on the carbon atoms at both ends of the double bond. This addition reaction can enrich the structure and properties of compounds and lay the foundation for the synthesis of complex organic molecules.
At the same time, the characteristics of carboxyl groups cannot be ignored. Carboxyl groups are acidic and can neutralize with bases to form corresponding carboxylic salts. In addition, carboxyl groups can also participate in esterification reactions. Under the action of catalysts with alcohols, a molecule of water is removed to form ester compounds. This ester compound is widely used in flavors, coatings and other industries. 5-Bromo-3-methylpentene-2-acid has a variety of chemical reactivity due to the synergistic action of bromine atom, double bond and carboxyl group, and has important application prospects in many fields such as organic synthesis and medicinal chemistry.

5-Bromo-3-methylpyridine-2-carboxylic acid is an important organic compound with critical uses in many fields.
In the field of medicinal chemistry, it is often used as a key intermediate for the synthesis of drug molecules with specific biological activities. Due to its unique chemical structure, it can interact with specific targets in organisms. For example, some compounds synthesized based on it have been found to have inhibitory activity on specific disease-related protein kinases and are expected to be developed as innovative drugs for the treatment of cancer, inflammation and other diseases.
In the field of materials science, it also plays an important role. Can participate in the preparation of functional organic materials, such as optoelectronic materials. With the electronic properties given by its molecular structure, it can regulate the photoelectric properties of materials. Organic Light Emitting Diode (OLED) materials prepared from this compound may have higher luminous efficiency and stability, and have great application potential in the field of display technology.
In agricultural chemistry, 5-bromo-3-methylpyridine-2-carboxylic acid can be used to create new pesticides. Due to its special mechanism of action against certain pests or pathogens, it can be developed as a highly efficient, low-toxic and environmentally friendly pesticide product, helping to improve crop yield and quality while reducing adverse effects on the environment.
Furthermore, in the field of organic synthesis chemistry, as a multifunctional intermediate, it provides an effective way to construct complex organic molecular structures. Chemists can use its activity check point to introduce different functional groups through various organic reactions, such as nucleophilic substitution, coupling reactions, etc., to expand the structural diversity of organic molecules, and then promote the development of organic synthesis chemistry.
In short, 5-bromo-3-methylpyridine-2-carboxylic acids have shown important application value in many fields such as medicine, materials, agriculture and organic synthesis, and are of great significance to technological innovation and development in various fields.

To prepare 5-bromo-3-methylpyridine-2-carboxylic acid, the following methods can be used:
First, 3-methylpyridine is used as the starting material. First, 3-methylpyridine is brominated, and a suitable brominating reagent can be selected, such as bromine ($Br_2 $). Under a suitable catalyst, such as iron powder or iron tribromide, at a suitable temperature and reaction environment, the bromine atom replaces the hydrogen atom at a specific position on the pyridine ring to obtain 5-bromo-3-methylpyridine. Then, using a suitable oxidation reagent, such as potassium permanganate ($KMnO_4 $), the methyl is oxidized to a carboxyl group under basic conditions, and after acidification treatment, 5-bromo-3-methylpyridine-2-carboxylic acid is obtained. This process requires fine control of the reaction conditions. Due to the special properties of the pyridine ring, the position selectivity of bromination and the degree of oxidation reaction need to be carefully controlled.
Second, the pyridine derivative containing the appropriate substituent can be started. For example, if there is a suitable pyridine derivative containing a group that can be converted into a carboxyl group at the 2-position, a methyl group at the 3-position, and a bromine atom can be introduced at the 5-position. First, through a suitable halogenation reaction, bromine atoms are introduced at the 5-position, and different halogenation methods can be selected according to the characteristics of the substrate. After that, the 2-position group is converted into a carboxyl group, which varies according to the properties of the original 2-position group. For example, the ester group can be hydrolyzed to obtain a carboxyl group, and the nitrile group can be hydrolyzed or reacted with Grignard reagents to obtain a carboxyl group.
Third, the strategy of building a pyridine ring is adopted. With suitable nitrogen-containing, carbon-containing and bromine-containing raw materials, a pyridine ring is constructed through a multi-step reaction. For example, under specific conditions, a series of reactions such as condensation and cyclization are used to form a pyridine ring with a desired 5-bromo-3-methyl-2-carboxylic acid-related substituent on the ring. Although this method has complex steps, it has unique advantages for the synthesis of target products with specific structures, and can design the pyridine ring structure from the source.
The above synthesis methods have advantages and disadvantages. In practical application, it is necessary to comprehensively consider the availability of raw materials, the difficulty of reaction conditions, the yield and cost, and select the optimal synthesis path.

I haven't heard of the market price of "5 -% deuterium-3-methylpyridine-2-carboxylic acid". However, in order to determine the range of its price, many factors must be examined.
First, the preparation of this product is difficult and easy, which is the main reason. If the preparation method is complicated, rare raw materials and exquisite processes are required, and the yield is quite low, the price will be high. On the contrary, if the preparation method is simple and the raw materials are easily available, the price will be cheap.
Second, the supply and demand of the market is also the key. If this acid is widely used in chemical, pharmaceutical and other industries, but the supply is limited, the price will be higher; if the demand is low and the supply is excessive, the price will be lower.
Third, the quality grade also affects its price. High purity, high quality, the price must be higher than ordinary ones.
Today's common chemicals in the market, those with the same quality, are difficult to prepare and have a wide demand for fine chemicals, and the price per gram may reach tens or even hundreds of yuan. If the preparation is slightly easier and the demand is average, the price per gram or a few yuan to tens of yuan.
However, "5 -% deuterium-3-methylpyridine-2-carboxylic acid" is more difficult to prepare than its ordinary counterparts due to the presence of deuterium. The acquisition and introduction of deuterium require specialized technology and equipment, and the cost is increasing.
Therefore, if it is laboratory grade and higher purity, the price per gram may be tens to hundreds of yuan; if it is industrial grade and lower purity, it may be a few to tens of yuan per gram. However, this is only an idea, and the actual price shall be subject to what is sold on the market.

The storage conditions of 5-bromo-3-methylpyridine-2-carboxylic acid are related to the stability and quality of this compound, and need to be carefully studied.
According to the principles of "Tiangong Kaiwu", the storage of things should be allowed to go with its own nature and avoid its harm. This compound has specific chemical properties and is susceptible to the influence of the surrounding environment.
First of all, the temperature should be controlled. It should be stored in a cool place. If it is exposed to high temperature, the thermal movement of molecules will intensify, or its structure will change, causing decomposition or reaction. In general, 5-bromo-3-methylpyridine-2-carboxylic acid should be stored in the range of 15 ° C to 25 ° C. This temperature range can ensure its chemical properties are relatively stable and reduce the risk of deterioration due to excessive temperature.
The second is the prevention of humidity. Moisture is often the culprit of chemical deterioration, and 5-bromo-3-methylpyridine-2-carboxylic acid is no exception. Adverse reactions such as moisture or hydrolysis damage its purity and quality. Therefore, it needs to be stored in a dry place, and it can be accompanied by a desiccant to absorb surrounding water vapor and maintain a dry environment.
Furthermore, light is also a potential threat to its deterioration. Optical radiation can provide energy, trigger photochemical reactions, and affect its stability. It is advisable to place it in a container protected from light, such as a brown glass bottle, to block light intrusion and maintain the integrity of its chemical structure.
It should also be noted that 5-bromo-3-methylpyridine-2-carboxylic acid should be placed separately from oxidizing, reducing and basic substances. Because its chemical structure contains active groups such as bromine and carboxyl groups, contact with the above substances, or initiate chemical reactions, causing it to deteriorate.
In summary, 5-bromo-3-methylpyridine-2-carboxylic acid should be stored in a cool, dry, dark place, and isolated from related reactive substances, so as to maintain its quality and stability for subsequent use.