5 Chloro 2 Fluoro 3 Methylpyridine
pyridine pyrrole pyrazine piperidine piperazine

5-chloro-2-fluoro-3-methylpyridine

    Specifications

    HS Code

    906101

    Chemical Formula C6H5ClFN
    Molar Mass 147.56 g/mol
    Appearance Typically a colorless to light - yellow liquid
    Boiling Point Data may vary, generally in a specific temperature range
    Density Specific value depending on conditions
    Solubility Solubility in common organic solvents like ethanol, etc. has a certain pattern
    Flash Point Has a defined flash point value
    Pka Characteristic acidity constant value
    Vapor Pressure Has a specific vapor pressure at given temperatures

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    General Information
    Where to Buy 5-chloro-2-fluoro-3-methylpyridine in China?
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    Frequently Asked Questions

    As a leading 5-chloro-2-fluoro-3-methylpyridine supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 5-chloro-2-fluoro-3-methylpyridine?
    5-Alkane-2-ene-3-methylpyridine has a wide range of uses. In the field of medicine, it is a key intermediate for the preparation of many effective drugs. Take a new type of drug for the treatment of cardiovascular diseases as an example, 5-alkane-2-ene-3-methylpyridine can be converted into an active ingredient with the functions of regulating blood lipids and stabilizing heart rhythm through a series of delicate chemical reactions, helping patients restore cardiovascular health.
    In the field of materials science, it has made great achievements in the synthesis of high-performance polymer materials. Introducing it into polymer structures can significantly improve the mechanical properties, thermal stability and chemical stability of materials. For example, through special processing, lightweight and high-strength composites suitable for aerospace can be produced, which can reduce the weight of aircraft and improve its reliability in extreme environments.
    In the field of agricultural chemistry, 5-alkane-2-ene-3-methylpyridine also has important applications. It can be used as an important raw material for the synthesis of high-efficiency and low-toxicity pesticides. With its unique chemical structure, it exhibits excellent repellent and killing effects on a variety of crop pests, while minimizing the impact on the environment and non-target organisms, effectively ensuring the safety and sustainable development of agricultural production.
    In summary, 5-alkane-2-ene-3-methylpyridine, with its unique chemical properties, plays an indispensable role in many key fields such as medicine, materials science, and agricultural chemistry, and has made significant contributions to the development of various industries.
    What are the physical properties of 5-chloro-2-fluoro-3-methylpyridine?
    5-Alkane-2-ene-3-methylpyridine, this is an organic compound. Its physical properties are quite important and are related to many practical applications and studies. Here is an ancient saying.
    Its appearance is often colorless to light yellow liquid, and it has a certain fluidity under normal temperature and pressure. Looking at its color, the colorless one is clear and translucent, and if it is light yellow, it is slightly elegant. Its smell may have a special smell, an unusual taste, but it is not pungent and intolerable, but has a unique fragrance, or it can be distinguished under specific circumstances.
    In terms of boiling point, it has a specific value due to the characteristics of molecular structure. Its boiling point determines the temperature at which the substance changes from liquid to gaseous state. This value is closely related to the intermolecular force. The intermolecular force of the compound makes its boiling point in a certain range, providing an important basis for chemical operations, separation and purification processes.
    Melting point is also a key physical property. Melting point characterizes the temperature point at which a substance converts from solid to liquid. For 5-alkane-2-ene-3-methylpyridine, its melting point is affected by factors such as molecular arrangement and lattice energy. In the solid state, the molecules are arranged in an orderly manner. When the temperature rises to the melting point, the molecules gain enough energy, and the lattice structure disintegrates, then becomes liquid.
    Solubility is also the focus of investigation. The substance has different behaviors in different solvents. In organic solvents such as ethanol and ether, it may have good solubility, and can form intermolecular interactions with solvent molecules, such as hydrogen bonds, van der Waals forces, etc., so as to uniformly disperse them. In water, due to the difference between molecular polarity and water, its solubility may be poor. This property has important considerations in substance extraction and reaction medium selection.
    Density cannot be ignored. Its density reflects the mass per unit volume. Compared with other substances, its position and distribution in the mixed system can be judged. In chemical production, substance separation operations, etc., density data are important references, and are related to the design and optimization of technological processes. The physical properties of 5-alkane-2-ene-3-methylpyridine, from appearance and odor to melting point, solubility, density, etc., are the cornerstones for in-depth understanding and research of this substance, and are of indispensable significance in many fields such as chemical industry, materials, and medicine.
    What are the chemical properties of 5-chloro-2-fluoro-3-methylpyridine?
    5-Alkane-2-ene-3-methylpyridine, this is an organic compound. Its chemical properties are unique, let me tell you in detail.
    As far as its unsaturation is concerned, it has the typical characteristics of olefins due to its carbon-carbon double bond. Addition reactions can occur. In case of halogen elements, such as bromine water, the electron cloud density at the double bond is high, which can attract bromine molecules, break the pi bond, and add to the bromine water. This is a commonly used method to test the carbon-carbon double bond. When adding with hydrogen halide, following the Markov rule, hydrogen atoms tend to be added to double-bonded carbon atoms containing more hydrogen to form halogenated hydrocarbons.
    From the perspective of the pyridine ring, the pyridine ring is aromatic, but the electronegativity of the nitrogen atom is greater than that of the carbon atom, resulting in uneven distribution of electron clouds on the ring. Pyridine rings can undergo electrophilic substitution reactions, but compared with benzene, the reactivity is slightly lower due to the electron-withdrawing action of the nitrogen atom. The substitution position is mainly at the β-position of the pyridine ring (relative to the nitrogen atom), because the electron cloud density at this position is relatively high. And the nitrogen atom on the pyridine ring can provide lone pairs of electrons, which can bind to protons, exhibit a certain alkalinity, and can react with acids to form salts.
    Furthermore, the methyl group is attached to the side chain of the pyridine ring and the double bond, and the methyl group has a certain electron induction effect, which affects the electron cloud density of the double bond and the pyridine ring, or causes the electron cloud density of the double bond to increase slightly, which affects the addition reaction activity; it may also affect the basicity of the pyridine ring, or slightly increase the basicity. At the same time, the methyl group can undergo free radical substitution reactions, such as reacting with halogen elements under light or high temperature, and hydrogen atoms are replaced by halogen atoms.
    In summary, 5-alkane-2-ene-3-methylpyridine is widely used in organic synthesis and related fields due to its rich and diverse chemical properties including carbon-carbon double bonds, pyridine rings and methyl groups.
    What are the synthesis methods of 5-chloro-2-fluoro-3-methylpyridine?
    There are many methods for the synthesis of 5-bromo-2-pentene-3-methyl ketone. Today I will describe it in detail.
    First, it can be obtained by the condensation reaction of β-carbonyl ester and halogenated olefins. Take β-carbonyl ester first, in a suitable solvent, under the catalysis of a base, to form an enol negative ion. This negative ion is nucleophilic and can undergo nucleophilic substitution reaction with halogenated olefins. If ethanol is used as a solvent and sodium hydride is used as a base, mix β-carbonyl ester with it, stir well, and after the enol negative ion is formed, slowly drop the halogenated olefins. The reaction process requires temperature control to maintain the system at a suitable temperature to ensure that the reaction proceeds in the direction of generating the target product. The conditions of this method are relatively mild and the operation is relatively simple.
    Second, it can be synthesized by the reaction of enol silica ether with acyl halogen. First prepare enol silica ether, and react with the corresponding enol and silanizing agent under the action of catalyst. After that, enol silica ether and acyl halogen react under the catalysis of Lewis acid. For example, using dichloromethane as the solvent and aluminum trichloride as Lewis acid, enol silica ether and acyl halogen are added to the system in sequence to stir the reaction. This reaction activity is high and the yield is considerable. Third, the Michael addition reaction strategy can be used. Appropriate α, β-unsaturated ketones and nucleophiles, such as compounds containing active hydrogen, are selected to carry out the Michael addition reaction under the catalysis of bases. For example, α, β-unsaturated pentenone and methyl ketones are used as raw materials, and ethanol potassium is a base. Through this reaction, the desired carbon-carbon bond can be formed, and then 5-bromo-2-pentene-3-methyl ketone can be generated. This method has good atomic economy and can introduce a variety of functional groups to facilitate the subsequent derivatization of the product.
    All synthesis methods have their own advantages and disadvantages. In practical applications, the choice needs to be weighed according to many factors such as the availability of raw materials, the difficulty of reaction conditions, the yield and the purity of the product, in order to achieve the best synthesis effect.
    What is the price range of 5-chloro-2-fluoro-3-methylpyridine on the market?
    5-Alkane-2-ene-3-methylpyridine, this substance is in the market, and its price range is not easy to determine. The change in its price depends on various reasons.
    First, the difficulty of production is different. If the preparation method is difficult, it requires all kinds of rare raw materials, or precise processes, involving high-risk operations, and takes a long time, the price will be high. If the preparation requires special catalysts, this agent is rare and expensive, or the reaction conditions are harsh, and high temperature, high pressure, and high purity environments are required, all of which increase the cost of production and cause high prices.
    Second, the amount of market demand matters. If in the pharmaceutical, chemical and other industries, the demand for them is strong, the supply is in short supply, and the price is self-rising. If a new type of drug is developed, it needs to be used as a key intermediate, and many pharmaceutical companies compete to buy, the price will rise. On the contrary, if the demand is weak, the supply exceeds the demand, and the price will fall.
    Third, the competition in the city is also the main reason. If there are many people competing with each other in the market, competing for profits for customers, or lowering their prices. However, if the market is controlled by a few merchants and is monopolized, they may manipulate the price to make it high.
    Fourth, the price varies from time to place. For a while, due to the abundance of raw materials and changes in policies, prices rose and fell. In different places, prices vary depending on transportation fees and taxes.
    Overall, the price of 5-alkane-2-ene-3-methylpyridine may fluctuate between hundreds of yuan per kilogram and thousands of yuan per kilogram, but the exact value must be determined according to real-time market conditions.