5 Chloro 2 Ethoxy 3 Nitro Pyridine
pyridine pyrrole pyrazine piperidine piperazine

5-chloro-2-ethoxy-3-nitro-pyridine

    Specifications

    HS Code

    278246

    Chemical Formula C7H7ClN2O3
    Molar Mass 202.596 g/mol
    Appearance Solid (predicted)
    Boiling Point Approx. 316.6 °C at 760 mmHg (estimated)
    Solubility In Water Low solubility (predicted)
    Solubility In Organic Solvents Soluble in common organic solvents like ethanol, acetone (predicted)
    Logp Approx. 2.2 (estimated)

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    General Information
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    Frequently Asked Questions

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    What are the physical properties of 5-chloro-2-ethoxy-3-nitropyridine?
    5-Bromo-2-ethoxy-3-pyridyl formaldehyde is an organic compound. The physical properties of this compound are related to its application in the field of chemistry. The following is detailed in the style of ancient Chinese:
    This compound is usually in a solid state, looking at its color, or in a white to light yellow powder form. Its color is elegant, like the early morning light, giving people a sense of purity. < Br >
    When it comes to melting point, the melting point of this substance is specific. During the heating process, when the temperature rises to a certain exact value, it gradually melts from the solid state to the liquid state. This melting point is one of its important physical characteristics, just like the "temperature code" of the substance itself, which plays a decisive role in its morphological changes under different temperature environments.
    Looking at its solubility, it shows good solubility in organic solvents, such as common ethanol, ether, dichloromethane, etc. This property is like a subtle affinity between it and organic solvents, which can be uniformly dispersed and fused. However, in water, its solubility is not good, just like the intolerance of oil and water. The boundary between the two is clear, which is determined by the molecular structure of the compound and the interaction between water molecules.
    In addition, its density is also a key physical property. The value of density represents the amount of substances contained in a unit volume of it, just like a standard for measuring its "compactness". The specific density makes the compound follow specific physical laws when participating in chemical reactions or separation and purification, which affects its distribution and behavior in the system.
    Its stability cannot be ignored. Under normal temperature and environmental conditions, 5-bromo-2-ethoxy-3-pyridyl formaldehyde has a certain stability and can maintain its own chemical structure and properties. However, in case of high temperature, strong light or specific chemical reagents, its stability may be damaged, the molecular structure will change, triggering a chemical reaction, just like throwing boulders into a calm lake, breaking the original tranquility. The physical properties of 5-bromo-2-ethoxy-3-pyridinal formaldehyde are unique and important, and these properties are interrelated to determine their application and performance in many fields such as organic synthesis and drug development. They are like the various parts of a precision machine, which are indispensable and synergistically promote the progress of chemical research.
    What are the chemical properties of 5-chloro-2-ethoxy-3-nitropyridine?
    5-Alkane-2-ethoxy-3-carbonyl pyridine, which has many chemical properties. It is weakly basic, because the pyridine ring nitrogen atom has lone pairs of electrons, which can bind protons. In an acidic environment, it can form pyridine salts. In case of hydrochloric acid, the corresponding pyridine hydrochloride will be formed. This salt is more soluble in water than the original substance.
    Its carbonyl properties are active and can occur a variety of reactions. It can react with nucleophiles, like with alcohols under acid catalysis, condensation reactions will occur to form acetals or hemi-acetals. If it reacts with Grignard reagents, the carbon negative ions in Grignard reagents attack carbonyl carbons, and alcohol compounds can be obtained by hydrolysis. < Br >
    The ethoxy moiety also participates in the reaction. Under basic conditions, nucleophilic substitution reactions may occur, such as substitution by other nucleophiles, such as substitution by hydroxyl groups to form alcohols. This reaction condition requires a strong base and a suitable temperature.
    In addition, the compound can undergo an addition reaction under specific conditions because it contains unsaturated bonds. For example, under the action of hydrogen in the catalyst, the pyridine ring and carbonyl group can be hydrogenated to form saturated derivatives and change the molecular structure and properties. In the field of organic synthesis, it can be used as an intermediate to construct more complex organic molecular structures through the above reactions.
    What is the common synthesis method of 5-chloro-2-ethoxy-3-nitropyridine?
    To prepare 5-bromo-2-ethoxy-3-furyl, there are several common methods as follows.
    First, the compound containing the furan structure can be started. First, the furan ring is modified with appropriate substituents to activate the specific position. Appropriate halogenated reagents, such as brominating agents, are used under appropriate conditions to selectively introduce bromine atoms into the target position to obtain bromine-containing furan derivatives. After that, ethoxy group is introduced, and ethanol and alkali are commonly used. Under heating and other conditions, ethoxy group is replaced by nucleophilic substitution reaction to obtain 5-bromo-2-ethoxy-3-furan group.
    Second, starting from simple hydrocarbons, the furan ring is gradually constructed. First, the intermediate containing carbon skeleton is constructed by suitable organic reactions, such as hydroxyaldehyde condensation. During the construction process, the reaction sequence and conditions are cleverly designed to enable the subsequent smooth introduction of bromine atoms and ethoxy groups. For example, the ethoxy group is introduced first, and ethanol can be used with suitable halogenated hydrocarbons or sulfonates to undergo a substitution reaction under alkali catalysis to connect the ethoxy group to the carbon chain. After that, a furan ring is formed by cyclization, and then bromine atoms are introduced at a predetermined position by means of bromination, and finally the synthesis of the target product is achieved.
    Third, a reaction involving metal-organic reagents is used to assist the synthesis. A metal-organic reagent containing a furan skeleton can be selected, such as a furan-based lithium reagent or a furan-based magnesium reagent. First, it reacts with a bromine-containing halogenated hydrocarbon to introduce a bromine atom. After that, it is combined with ethoxy-containing reagents, such as ethoxy halogenated hydrocarbons or ethoxy sulfonates, etc., under suitable catalysts and reaction conditions, so that ethoxy groups are connected to complete the synthesis of 5-bromo-2-ethoxy-3-furanyl. In this process, the activity and selectivity of metal-organic reagents are crucial to the success or failure of the reaction, and the reaction temperature, solvent and other conditions need to be precisely controlled to achieve a good reaction effect.
    In which fields is 5-chloro-2-ethoxy-3-nitropyridine used?
    5-Bromo-2-ethoxy-3-pyridyl is used in many fields.
    In the field of medicinal chemistry, it can be used as a key intermediate to help create new drugs. For example, when developing targeted drugs for specific diseases, with its unique chemical structure, it can precisely bind to specific targets of diseased cells, or can interfere with cell metabolic pathways and inhibit abnormal protein production, so as to achieve the purpose of treating diseases. For example, in the process of drug development for certain cancers and neurological diseases, it may play a key role.
    In the field of materials science, it also has its uses. For example, when preparing organic materials with special photoelectric properties, introducing 5-bromo-2-ethoxy-3-pyridyl into the molecular structure of the material may improve the conductivity and fluorescence properties of the material. In this way, the material may be applied to organic Light Emitting Diodes (OLEDs), solar cells and other fields to improve the performance of related devices.
    Furthermore, in the field of organic synthetic chemistry, it is an extremely important synthetic building block. Organic chemists can use various chemical reactions to perform functional group transformation, structural modification and other operations to construct more complex and diverse organic compounds. Many organic molecules with biological activity, optical activity or other special properties can be synthesized by ingeniously designing reaction routes with 5-bromo-2-ethoxy-3-pyridyl as the starting material, which greatly expands the variety and application range of organic compounds.
    What is the market prospect of 5-chloro-2-ethoxy-3-nitropyridine?
    5-Alkane-2-ethoxy-3-carbonyl pyridine, this compound is in the market and can be explored in the future. Looking at its properties, this compound has unique structural and chemical properties. In the field of organic synthesis, it is often a key intermediate. Due to the combination of alkane chains, ethoxy and carbonyl pyridine in its structure, it is endowed with diverse reactivity.
    In the field of medicinal chemistry, its structure can be modified to find derivatives with biological activity. Because pyridine rings are common in many drug molecules, and carbonyl and ethoxy groups can affect the lipophilicity, polarity and interaction with biological targets of molecules, they may have potential medicinal value and can be developed into new therapeutic drugs, which has development opportunities in the market.
    In the field of materials science, it also has application potential. Its special structure may be used to prepare functional materials, such as organic semiconductor materials. After rational design and synthesis, it may be able to adjust the electrical and optical properties of materials to meet different needs. For example, in organic Light Emitting Diode (OLED), field effect transistor (OFET) and other devices, it is expected to show good performance and develop markets in related industries.
    However, its market prospects also face challenges. The synthesis of this compound may require complex steps and specific reagents, and the cost may be high, which affects its large-scale production and marketing activities. And the market competition is fierce, if you want to stand out, you need to have significant advantages in performance, cost control and application development. Overall, the market prospect of 5-alkane-2-ethoxy-3-carbonyl pyridine is promising, but it also needs to overcome the problems of synthesis and market competition to fully realize its commercial value.