5-Chloro-1H-pyrrolo[2,3-b]pyridine

5-Chloro-1H-pyrrolido [2,3-b] pyridine is one of the organic compounds. Its physical properties are quite critical and are the key points for everyone to explore.
Looking at its properties, it is mostly white to light yellow solid powder under normal circumstances. This form is easy to store and transport. In many chemical reactions, the powdered substance can increase the contact area with other reactants, which is conducive to the reaction.
When it comes to the melting point, it is about 155-159 ° C. The melting point is the critical temperature at which a substance changes from a solid state to a liquid state. This specific melting point range can help chemists accurately judge the purity and state change of the substance during the experimental process, providing an important basis for synthesis, purification and other operations.
Its solubility is also worthy of attention. Slightly soluble in water, but soluble in common organic solvents such as dichloromethane, N, N-dimethylformamide, etc. This solubility characteristic is of great significance for the choice of reaction solvent in organic synthesis experiments. According to its solubility in different solvents, a suitable solvent can be selected to promote the efficient progress of the reaction in the desired direction, or for the separation and purification of the product.
In addition, the compound has certain stability, but under certain conditions, such as high temperature, strong acid, and strong alkali environment, its structure may change. Knowing this stability characteristic, during storage and use, you can know what conditions to avoid to prevent material deterioration, ensure its chemical properties are constant, and then ensure the smooth development of relevant experiments and production processes.

5-Chloro-1H-pyrrolido [2,3-b] pyridine, this is an organic compound. Its chemical properties are unique and allow me to elaborate.
First of all, its chlorine atoms, chlorine, and halogen elements give this compound a certain activity. Chlorine atoms can participate in many reactions, such as nucleophilic substitution reactions. Under appropriate conditions, nucleophiles can attack the carbon atoms attached to chlorine, and the chlorine atoms leave to form new compounds. This reaction can be used to introduce other functional groups to expand the chemical structure of the compound.
Furthermore, the cyclic structure of pyrrolido-pyridine has aromatic properties. Aromatic systems are usually relatively stable, but they also give them special reactivity. Due to the existence of the conjugated system, the electron cloud distribution is special, and electrophilic substitution reactions can occur. For example, it can react with electrophilic reagents to introduce substituents on the pyridine or pyrrole ring, and the reaction check point is affected by the density distribution of the electron cloud on the ring.
From the perspective of acidity and alkalinity, nitrogen atoms exist in the structure. The nitrogen on the pyridine ring is weakly basic, acceptable for protons, and reacts with acids to form salts. The nitrogen of the pyrrole ring, due to the participation of lone pairs of electrons in the conjugated system, is weakly basic, and under certain conditions, has a certain acidity, and can react with strong bases to lose protons.
The chemical properties of this compound are crucial in the field of organic synthesis. With its active chlorine atom and special cyclic structure, it can synthesize a variety of biologically active compounds, which have potential applications in medicinal chemistry, materials science and many other fields. Or through ingenious chemical reactions, complex organic molecules can be constructed, providing a basis for exploring the properties and functions of new substances.

5-Chloro-1H-pyrrolido [2,3-b] pyridine, an organic compound, has important applications in many fields such as medicinal chemistry and materials science.
In the field of medicinal chemistry, its role is crucial. Many drug development takes it as a key intermediate. Because of its unique chemical structure, it can interact with specific targets in organisms. For example, in the development of anti-tumor drugs, scientists hope to obtain compounds with high selective inhibitory effect on tumor cells by modifying and modifying their structures. This compound can be used to build a unique bioactive molecular skeleton, and its physicochemical properties and biological activities can be changed by introducing different substituents, so as to screen for anti-cancer drugs with good efficacy and small side effects.
In the field of materials science, 5-chloro-1H-pyrrolido [2,3-b] pyridine is also used. In the field of organic optoelectronic materials, because of their specific electronic structure and optical properties, they can be used to prepare organic Light Emitting Diodes (OLEDs), organic solar cells and other devices. It can be used as a light-emitting layer material or an electron transport material, which is of great significance to improve the luminous efficiency and stability of the device. In OLEDs, proper selection of such nitrogen-containing heterocyclic compounds as luminescent materials can achieve high-efficiency electroluminescence, thereby improving the image quality and performance of the display screen.
In addition, in the field of pesticide chemistry, it is also involved. It can be used as a lead compound to design new pesticides through structural optimization. Because it can interact with specific biomacromolecules in pests and interfere with their normal physiological metabolism, it can achieve insecticidal and bactericidal effects, providing new ways and methods for agricultural pest control. In short, 5-chloro-1H-pyrrolido [2,3-b] pyridine has shown great application potential and research value in many important fields.

The synthesis method of 5-chloro-1H-pyrrolido [2,3-b] pyridine is quite complicated, and now I will describe one or two of them.
The common method is to choose the starting material of pyridine derivatives, supplemented by halogenating reagents, such as chlorine-containing halogenating agents. Under suitable reaction conditions, such as specific temperature, pressure and catalyst, the halogenating agent interacts ingeniously with the pyridine derivative, so that the chlorine atom precisely replaces the hydrogen atom at a specific position in the pyridine ring, and then the chlorine-containing pyridine intermediate is obtained.
Then, the intermediate and the compound with pyrrole structure, under the catalysis of base or other promoters, undergo cyclization reaction, so that the pyrrole structure is cleverly connected to chloropyridine, and finally 5-chloro-1H-pyrrolido [2,3-b] pyridine.
Another method is to start with pyrrole derivatives, and first through a specific reaction, a suitable substituent is introduced to lay the foundation for the subsequent connection with the pyridine ring. Then through the pyridine-related reagents, in a suitable reaction environment, the pyridine ring is gradually constructed, and during the construction process, the reaction conditions are carefully regulated to promote the chlorine atoms to fall accurately at the target position, so as to complete the synthesis of 5-chloro-1H-pyrrolido [2,3-b] pyridine.
Or you can start from a simple organic small molecule and gradually build the structural unit of pyridine and pyrrole through a multi-step reaction, and ingeniously introduce chlorine atoms to finally achieve the synthesis of this compound. However, there are many steps in this way, and the control of the reaction conditions needs to be extremely precise. If there is a slight difference, it is difficult to obtain the ideal product.

5-Chloro-1H-pyrrolido [2,3-b] pyridine, this product is in the market, and its price range is difficult to determine. The price often varies due to many factors, such as the difficulty of preparation, the price of raw materials, the amount of market demand, and the abundance of supply.
If it is prepared, if the synthesis process is complicated, rare or expensive raw materials are required, or the steps are cumbersome and time-consuming, the cost will be high, and the price will rise accordingly. On the contrary, if the preparation method is simple, the raw materials are easily available and inexpensive, the price may be slightly lower.
The situation of market demand is also the key. If there is a large demand for this product in the fields of medicine, chemical industry, etc., and the supply is limited, when the supply is in short supply, its price will rise. If there is little demand and excess supply, the price may drop.
Looking at the market in the past, the price of similar compounds may vary from time to time, ranging from hundreds of yuan per kilogram to thousands or even higher. However, 5-chloro-1H-pyrrolido [2,3-b] pyridine, it is difficult to determine its exact price. To know its price, you can consult a chemical raw material supplier or a professional chemical product trading platform to get a more accurate price.