5-Bromopyridine-2-carboxamide

5-Bromopyridine-2-formamide has a wide range of uses. In the field of medicinal chemistry, it is a key organic synthesis intermediate, which can be derived from many bioactive compounds through various chemical reactions. Many drugs are often regarded as starting materials in the process of drug development. For example, in the development of anti-tumor drugs, by modifying and modifying its structure, it is expected to obtain new drug molecules with specific targeting properties and can effectively inhibit the proliferation of tumor cells.
In the field of materials science, 5-bromopyridine-2-formamide also has important applications. Some researchers use it as a raw material to prepare polymer materials with unique photoelectric properties through polymerization reactions and other means. These materials may be applied to organic Light Emitting Diode (OLED), solar cells and other photoelectric devices to help improve device performance and efficiency.
In addition, in pesticide chemistry, it can also be used to synthesize a variety of highly efficient, low-toxicity and environmentally friendly pesticides. After optimizing its chemical structure, pesticide products with high selectivity and activity for specific pests or diseases can be developed to meet the needs of modern agriculture for green and sustainable pesticides. Overall, 5-bromopyridine-2-formamide has shown great application potential in many important fields, which is of great significance for promoting the development of related fields.

5-Bromopyridine-2-formamide, this is an organic compound. Looking at its physical properties, it is mostly solid at room temperature, and its color is white or slightly yellow. This color changes slightly due to the preparation process or the influence of impurities. Its melting point is in a specific range, about [X] ° C, which is determined by the intermolecular force. This force maintains the molecule in the lattice, and when heated to the melting point, the molecule is energized, the lattice disintegrates, and then melts into a liquid state.
When it comes to solubility, it has certain solubility in common organic solvents, such as ethanol and dichloromethane. Ethanol is a polar solvent, and 5-bromopyridine-2-formamide contains polar groups, which are soluble in it due to the principle of "similar miscibility". Although dichloromethane has weak polarity, it has van der Waals force interaction with the compound molecules, which can also make it partially soluble. However, in water, its solubility is poor, because the polarity of water is quite different from that of the compound, and its intermolecular hydrogen bond is difficult to interact effectively with water.
Its density is also one of its characteristics, about [X] g/cm ³, which is determined by its molecular structure and atomic weight compared with other similar organic compounds. Density reflects the compactness of molecules, which is of great significance in chemical operations and separation processes, and is related to the distribution and behavior of substances in the system.
The physical properties such as appearance, melting point, solubility and density of 5-bromopyridine-2-formamide are crucial in the field of organic synthesis and drug development. During synthesis, the melting point helps to judge the purity, and the solubility is related to the choice of reaction medium; in drug development, these properties affect the absorption and distribution of drugs, which are important considerations for the creation of new drugs.

The synthesis method of 5-bromopyridine-2-formamide has been explored by many wise men throughout the ages. One of the common synthesis methods is to use 5-bromopyridine-2-formic acid as the starting material. The acid is first heated with an appropriate reagent, such as sulfuryl chloride, at a suitable temperature. This process can convert the acid into the corresponding acid chloride. Sulfuryl chloride is active, can react efficiently with carboxyl groups to form acid chloride, and the by-products are all gases, which are easy to separate. The resulting acyl chloride reacts with ammonia gas or ammonia alcohol solution, and the active chlorine atom of the acyl chloride can be replaced by the amino group of ammonia to obtain 5-bromopyridine-2-formamide. In this process, the amount of ammonia gas, the temperature of the reaction and the length of the reaction time all affect the formation of the product.
The second method is to use 5-bromopyridine-2-cyanopyridine as a raw material. It is placed under basic conditions, such as sodium hydroxide or potassium hydroxide in an aqueous solution, and heated for hydrolysis. The cyano group is hydrolyzed and gradually converted into a carboxyl group, which is then reacted with ammonia to form an amide. This hydrolysis reaction requires attention to the control of the concentration of the base, the reaction temperature and time. If the concentration of the base is too high, the temperature is too high or the time is too long, the product may be over-hydrolyzed or other side reactions may occur, affecting the purity and yield of the product.
In addition, pyridine is used as the starting material. After bromination, bromine atoms are introduced at the 5th position of the pyridine ring, and then formylation is carried out. Finally, the target product 5-bromopyridine-2-formamide is obtained through the amidation step. When brominating, choose the appropriate brominating reagent, such as bromine or N-bromosuccinimide (NBS), and control the reaction conditions to introduce the bromine atom precisely into the fifth position. The formylation and amidation steps also need to be carefully adjusted according to different reagents and conditions to obtain satisfactory results.
All synthetic methods have their own advantages and disadvantages. In practical application, it is necessary to weigh and choose according to the availability of raw materials, the difficulty of controlling the reaction conditions, and the requirements for product purity and yield.

The price of 5-bromopyridine-2-formamide in the market is difficult to determine. The change in its price depends on many ends. Looking at the past, the price movement of this chemical product is related to the state of supply and demand, manufacturing costs, market competition and other reasons.
If it comes to supply, the abundance of raw materials and the production capacity of manufacturers will all be influenced. If the raw materials are sufficient and the production capacity is high, the supply will be large, and the price will decline; conversely, if the raw materials are scarce and the production capacity is limited, the supply will be small, and the price will rise.
On the demand side, in the pharmaceutical, pesticide, material and other industries, if it is widely used and seeks prosperity, the price will also be pushed up; if it is not needed, the price will not be high.
Manufacturing costs are also heavy, and the price of raw materials, energy consumption, labor costs, etc., are all related to the cost. If raw materials are expensive, energy consumption is high, and labor costs are high, the cost will increase, and the price will also rise.
The competition in the city cannot be ignored. If there are many producers and many competing products, it is a competition for the market, or there is a move to reduce the price; conversely, if there are few producers and few competing products, the price may rise steadily.
In the past, the price of such chemicals ranged from a few yuan to tens of yuan per gram. However, market conditions change, the current price may vary due to changes in the above factors. To know the exact price, it is advisable to consult chemical raw material suppliers, chemical product trading platforms, etc., to obtain real-time prices.

5-Bromopyridine-2-formamide is an organic compound. When storing and transporting, be sure to pay attention to the following things.
First, the storage environment. This compound should be stored in a cool, dry and well-ventilated place. Do not place it in a high temperature or humid place. Due to high temperature or its decomposition, moisture can easily cause deliquescence and other conditions, which will damage the quality of the compound. Keep away from fire and heat sources to prevent the risk of fire.
Second, the material of packaging. When storing and transporting, the packaging must be tight. Appropriate packaging materials, such as glass bottles, plastic bottles, etc., should be used and sealed properly. If the package is damaged, it is easy to cause it to come into contact with air, moisture, etc., resulting in deterioration.
Third, isolated storage. It should be stored separately from oxidants, acids, alkalis, etc., and must not be mixed in storage and transportation. Due to its chemical properties, contact with these substances, or severe chemical reactions occur, resulting in danger.
Fourth, transportation requirements. During transportation, it is necessary to ensure that the container does not leak, collapse, fall, or damage. Transportation vehicles should be equipped with corresponding varieties and quantities of fire-fighting equipment and leakage emergency treatment equipment. During driving, it is necessary to protect against exposure to the sun, rain, and high temperature.
Fifth, clear signs. The name, nature, warning label and other information of the compound should be clearly marked on the package to facilitate identification and handling, and in case of emergency, appropriate measures can be taken quickly. In this way, the safety and quality of 5-bromopyridine-2-formamide during storage and transportation are guaranteed.