(5-Bromomethyl-pyridine-2-YL)Carbamic Acid Tert-Butyl Ester

The chemical structure of tert-butyl carbamate (5-bromomethyl-pyridine-2-yl) is as follows: the pyridine ring is the core structure, and the tert-butyl carbamate group is connected at the 2 position of the pyridine ring, that is, the amino group (-NH-) is connected to the pyridine ring at one end, and the other end is connected to the carbonyl group (C = O), which is then connected to the tert-butoxy group (-OC (CH)) at the 5 position of the pyridine ring. In this structure, the pyridine ring provides aromaticity and certain electron cloud distribution characteristics. The tert-butyl group of the carbamate part has a large steric resistance, which affects the stability and reactivity of the molecule. The bromine atom in the bromomethyl group has strong reactivity and can undergo various reactions such as nucleophilic substitution. This unique structure makes it have important application value in the fields of organic synthesis and medicinal chemistry.

(5-Bromomethyl-pyridine-2-yl) tert-butyl carbamate, this compound has a wide range of uses. In the field of organic synthesis, it is often used as a key intermediate. It contains both bromomethyl and carbamate tert-butyl groups in its molecule, and has high activity of bromomethyl. It is prone to nucleophilic substitution reactions, such as interacting with nucleophiles containing nitrogen, oxygen, and sulfur. It can introduce multiple functional groups to help build complex organic molecules.
In the field of medicinal chemistry, this compound is also of great significance. After structural modification and optimization, it can design and synthesize drug molecules with specific biological activities. For example, using it as a starting material, through a series of reactions, drug lead compounds with high affinity and selectivity for specific disease targets may be obtained, laying the foundation for the development of new drugs.
In the field of materials science, it may be able to participate in the preparation of functional materials. Through its reactivity, polymerization or modification with other monomers, the material is endowed with unique properties, such as optical, electrical or mechanical properties, and then meets the needs of different application scenarios. In short, tert-butyl (5-bromomethyl-pyridine-2-yl) carbamate is an indispensable chemical raw material in many fields, and is of great significance to promote the development of related fields.

The synthesis method of tert-butyl (5-bromo-methyl-pyridine-2-yl) carbamate is an important topic in the field of organic synthesis. There are various synthesis methods, each with its own advantages and disadvantages, which are suitable for different scenarios.
One is to use 2-amino-5-methylpyridine as the starting material. The amino group is first protected to prevent side reactions in subsequent reactions. Tert-butoxycarbonyl (Boc) is often used as the protective group, and the amino group is connected to the Boc protective group by reacting with di-tert-butyl dicarbonate (Boc 2O O) catalyzed by an appropriate base (such as triethylamine). Subsequently, the methyl group is converted into bromomethyl by bromination reaction. The commonly used bromination reagent is N-bromosuccinimide (NBS). Under the conditions of initiator (such as benzoyl peroxide) and light or heating, the bromine radical in NBS attacks the methyl group to achieve bromination and obtain the target product. The raw material of this route is common and the operation is relatively conventional, but the bromination step needs to pay attention to the control of reaction conditions to avoid excessive bromination.
The second is to use 2-chloro-5-methylpyridine as the starting material. The chlorine atom is first replaced with an amino group, which can be achieved by working with ammonia at high temperature and pressure and a suitable catalyst (such as copper catalyst). Then the amino group is protected by Boc, which is similar to the above method. Then the methyl group is brominated to obtain the product. The chlorine substitution amino group step in this route has harsh conditions and high equipment requirements, but it can avoid some problems in the source of raw materials.
The third can be started from pyridine-2,5-dicarboxylic acid. First, one carboxyl group is converted into methyl ester, and the other carboxyl group is converted into amino group through a series of reactions and protected by Boc. Then the methyl group is brominated to obtain the final target product. This route has a little more steps, but the raw material stability is good, which is suitable for large-scale production optimization.
When synthesizing tert-butyl carbamate (5-bromo-methyl-pyridine-2-yl), it is necessary to carefully select suitable synthesis methods according to actual conditions, such as raw material availability, cost, target product purity and yield requirements, and carefully optimize reaction conditions to improve yield and purity.

Tert-butyl carbamate (5-bromomethyl-pyridine-2-yl) is an important compound in organic chemistry. Looking at its physical properties, at room temperature and pressure, it is mostly white to white solid state. Due to the intermolecular force, it has a relatively regular arrangement, so it becomes a solid state.
Its melting point is within a specific range, but the exact value is affected by many factors, such as purity, measurement method, etc. It is difficult to determine an exact value for the time being. However, roughly speaking, its melting point range can help chemists control the conditions during experiments.
Furthermore, its solubility is also a key physical property. In common organic solvents, such as dichloromethane, chloroform and other halogenated hydrocarbon solvents, it has good solubility. This is because the molecular structure of the compound and the halogenated hydrocarbon molecules can form appropriate interactions, such as van der Waals forces, etc., so that it can be uniformly dispersed in the solvent. In water, its solubility is poor. Because the hydrophobic part of the molecule accounts for a large proportion, it is difficult to form an effective interaction with water molecules. The polarity of water does not match the polarity of the compound, so it is difficult to dissolve.
In addition, the stability of the compound is also considerable. Under normal conditions, its chemical structure can remain relatively stable, and it is not prone to spontaneous decomposition or other chemical reactions. However, under extreme conditions such as strong acids, strong bases, or high temperatures, some chemical bonds in its structure may break or rearrange, which is also a key consideration when using and storing this compound.

Tert-butyl (5-bromomethyl-pyridine-2-yl) carbamate is a compound that has attracted much attention in the field of organic synthesis. Looking at its market prospects, it is of great value in the process of pharmaceutical research and development. In the creation of many new drugs, it is often used as a key intermediate, with the help of which a unique molecular structure can be built, opening up a path for the exploration of new drugs. The unique structure of tert-butyl (5-bromomethyl-pyridine-2-yl) carbamate can just fit this pursuit, and it has emerged in the research and development of anti-tumor and antiviral drugs.
In the field of materials science, it also shows potential applications. With the surge in demand for advanced materials, the synthesis of some functional materials can introduce the compound to give the material different properties, such as special optical and electrical properties.
From the perspective of market supply and demand, with the advancement of related scientific research projects and the acceleration of industrial transformation, the demand for it is on the rise. However, its synthesis process has a certain complexity, resulting in high production costs and limiting the scale of supply to a certain extent. Therefore, improving synthesis technology and reducing costs have become the key to unlocking market potential. If this problem can be overcome, the market prospect of tert-butyl (5-bromo-methyl-pyridine-2-yl) carbamate will be broader, and it will play a greater role in many fields.