5-Bromo-PYRIDINE-3-Carbaldehyde

5-Bromo-pyridine-3-formaldehyde, this is an organic compound. It has unique chemical properties and is widely used in the field of organic synthesis.
Looking at its structure, the pyridine ring is a six-membered heterocycle characterized by a nitrogen atom, and the 5-position bromine atom is cleverly connected to the 3-position aldehyde group. The aldehyde group is a highly reactive functional group that can participate in many chemical reactions. For example, it can undergo nucleophilic addition reactions with nucleophiles. Common nucleophilic reagents such as alcohols, under certain conditions, the carbonyl carbon of the aldehyde group is attacked by the nucleophilic oxygen atom in the alcohol to form hemiacetal or acetal products. This reaction is often used in organic synthesis to protect the aldehyde group or to construct complex carbon-oxygen bond structures.
Bromine atoms are also active functional groups. Under metal-catalyzed conditions, coupling reactions can occur, such as with metal-containing organic reagents, such as Grignard reagents or organolithium reagents, to achieve the construction of carbon-carbon bonds, providing an effective path for the synthesis of various pyridine derivatives. Moreover, bromine atoms can also be replaced by other functional groups, which can be converted into hydroxyl groups, amino groups, etc. according to different reaction conditions and reagents, which greatly enriches the derivatization possibilities of this compound. 5-Bromo-pyridine-3-formaldehyde plays an important role in the construction of complex organic molecular structures due to the existence of aldehyde groups and bromine atoms, and has important applications in many fields such as medicinal chemistry and materials science.

5-Bromo-pyridine-3-formaldehyde, an important raw material in organic chemistry, is widely used in many fields.
In the field of medicinal chemistry, it is often a key intermediate for the synthesis of drugs. Through ingenious chemical reactions, it can be converted into compounds with specific pharmacological activities to develop new drugs. For example, some drug creations targeting specific disease targets, 5-bromo-pyridine-3-formaldehyde can be reacted in multiple steps to build complex drug molecular structures, or used to regulate human physiology for drug development, which is of great significance for the treatment of diseases.
In the field of materials science, it is also useful. It can participate in the synthesis of organic materials with special properties, such as materials with unique photoelectric properties. After specific chemical modification and polymerization, the substance can be integrated into the molecular structure of the material, endowing the material with special properties such as luminescence and conductivity, providing a foundation for the development of organic Light Emitting Diode (OLED), organic solar cells and other materials, and promoting the progress of materials science.
Furthermore, in the field of organic synthetic chemistry, 5-bromo-pyridine-3-formaldehyde is often used as a key starting material. Due to the presence of bromine atoms and aldehyde groups in its molecular structure, it is endowed with rich reactivity. A variety of chemical reactions such as nucleophilic substitution, oxidation, and reduction can be carried out to build a diverse organic molecular framework, providing an effective path for the synthesis of complex organic compounds and promoting the development of organic synthetic chemistry.

To prepare 5-bromo-3-pyridyl formaldehyde, the following methods are often followed.
First, 3-pyridyl formaldehyde is used as the starting material. Dissolve 3-pyridyl formaldehyde into an appropriate solvent, such as dichloromethane, and cool to a certain low temperature, such as about 0 ° C. Slowly add a brominating reagent, such as N-bromosuccinimide (NBS), and add a small amount of initiator, such as benzoyl peroxide. Stir the reaction at low temperature and monitor the reaction progress closely by thin-layer chromatography (TLC). When the raw material point disappears, the reaction is complete. The reaction solution was washed with sodium bicarbonate solution, except for the unreacted brominating reagent, and then the organic phase was dried with anhydrous sodium sulfate, and the solvent was removed by rotary evaporation to obtain a crude product. Purified by column chromatography to obtain pure 5-bromo-3-pyridine formaldehyde.
Second, start from 5-bromo-3-methylpyridine. First, 5-bromo-3-methylpyridine and an appropriate amount of oxidant, such as potassium permanganate or potassium dichromate, are co-placed in an appropriate solvent and an alkaline environment, such as water-acetone as a solvent, plus an appropriate amount of sodium carbonate. Heat the reflux reaction, and monitor it during TLC. After the raw materials are exhausted, the reaction liquid is cooled, acidified to acidic with dilute hydrochloric acid, and a solid is precipitated. Filter, wash with water, and dry to obtain 5-bromo-3-pyridinecarboxylic acid. Then 5-bromo-3-pyridinecarboxylic acid is reacted with lithium aluminum hydride (LiAlH) in anhydrous ether and other solvents, and the reactants are added at low temperature. After the reaction is completed, the hydrolysis is carefully carried out, and then purified by extraction, drying, rotary evaporation, and column chromatography to obtain 5-bromo-3-pyridinecarboxylic alcohol.
Or, use 5-bromo-3-pyridinecarboxy In a suitable solvent, such as dichloromethane, add an appropriate amount of Dess-Martin reagent, stir the reaction at room temperature. TLC monitoring, when the raw material is completely converted, wash with saturated sodium thiosulfate solution, remove excess Dess-Martin reagent, and operate through drying, rotary steaming, column chromatography, etc., 5-bromo-3-pyridine formaldehyde can also be obtained.

5-Bromo-pyridine-3-formaldehyde is an organic compound. When storing, many aspects need to be paid attention to.
First, temperature and humidity are the key. This compound should be stored in a cool and dry place. Because it may be sensitive to heat and humidity, high temperature and humid environment may cause it to deteriorate. At high temperature, it may cause chemical reactions and cause structural changes; in humid environment, it may absorb moisture, affect purity, or even undergo reactions such as hydrolysis. Therefore, the storage temperature should be controlled at room temperature or slightly lower, and the humidity should be kept at a relatively low level, such as humidity 40% - 60%.
Second, light also affects. The compound may be photosensitive, and light may cause it to undergo photochemical reactions, resulting in changes in properties. Therefore, it should be stored in a dark place, such as in a brown bottle, or in a warehouse without direct light.
Third, the packaging should be appropriate. Sealed packaging should be used to prevent contact with air. Components such as oxygen and carbon dioxide in the air may react with the compound. Sealed packaging can avoid its interaction with air components and maintain its stability. At the same time, the packaging material should also be considered, and materials that do not react with the compound should be selected.
Fourth, the storage location should be away from fire, heat and strong oxidants. This compound may be flammable, and there is a risk of combustion in case of fire and heat sources; strong oxidants can oxidize with it, causing it to deteriorate, so it needs to be stored separately to ensure safety.
In short, when storing 5-bromo-pyridine-3-formaldehyde, proper control of temperature, humidity, light, packaging and storage location can ensure its quality and stability.

5-Bromo-pyridine-3-formaldehyde, the price of this product in the market often changes due to many reasons. Looking at the market conditions of the past, the demand and supply of materials, the simplicity of the manufacturing process, and the quality of the quality are all variables in the price.
If the supply of materials is abundant and the supply is small, the price will be high. If there are many people who want it, they will all want it, and the merchants will raise the price accordingly. As in the past, at a certain time, the pharmaceutical industry was in a hurry for it, but the number of producers did not increase sharply, resulting in high prices.
The simplicity of the manufacturing process is also related to the price. If the production requires exquisite methods, rigorous processes, and laborious consumables, the price will be high. Because of its high cost, merchants must seek generous profits to make up for the expenses. If the manufacturing process is gradually improved, the cost will drop slightly, and the price may also drop.
The quality of the product is also the main reason for the price. Those with high purity and few impurities must be higher than the regular product. If it is suitable for high-end fields, such as pharmaceutical research and development, the quality requirements are very strict, so the price is not cheap.
According to the ancient market conditions, the price of 5-bromo-pyridine-3-formaldehyde may be between tens of yuan and hundreds of yuan per gram. However, this is only an approximate number, and the market is not constant, and the price is also variable, or varies greatly from time to time and situation to situation. Businesspeople entering the market must scrutinize the market conditions and take advantage of the current situation before they can know the changes in prices and seek good profits.