5-Bromo-Pyridine-2-Carboxylic Acid

5-Bromopyridine-2-carboxylic acid has a wide range of main uses. In the field of pharmaceutical synthesis, this compound plays a crucial role. Due to its unique chemical structure, it can be used as a key intermediate for the preparation of many drugs with specific pharmacological activities. For example, in the development of some new drugs targeting specific disease targets, 5-bromopyridine-2-carboxylic acid can be ingeniously introduced into the molecular structure of the drug through a series of chemical reactions, thus endowing the drug with unique pharmacological properties and helping the drug to achieve precise treatment of diseases.
In the field of pesticides, it has also shown significant role. It can be used as an important raw material for the synthesis of high-efficiency and low-toxicity pesticides. Through reasonable chemical modification and synthesis processes, pesticide products with high-efficiency killing or inhibitory effects on crop pests can be created. Such pesticides can not only effectively protect crops from pest attacks, ensure food yield and quality, but also have relatively little impact on the environment and non-target organisms due to low toxicity, which meets the needs of current green agriculture development.
In addition, in the field of organic synthetic chemistry research, 5-bromopyridine-2-carboxylic acid is an important building block for organic synthesis. Chemists can construct complex organic compounds with diverse structures and functions through various organic reactions, such as nucleophilic substitution reactions and coupling reactions, according to their structural characteristics. These compounds have potential applications in materials science, total synthesis of natural products, and many other fields, providing a rich material foundation for scientific research and technological innovation in related fields.

The synthesis method of 5-bromopyridine-2-carboxylic acid has been known in ancient times, and there are many methods, which are now the number of Jun Chen.
First, pyridine-2-carboxylic acid is used as the starting material and can be prepared by bromination reaction. In this method, liquid bromine or N-bromosuccinimide (NBS) is often used as the bromination reagent. If liquid bromine is used as the bromine source, in the presence of suitable catalysts such as iron powder or iron tribromide, pyridine-2-carboxylic acid reacts with liquid bromine in a suitable solvent (such as dichloromethane or chloroform). When reacting, it is necessary to pay attention to the regulation of temperature. Generally, it starts at a low temperature and gradually rises to a moderate temperature to ensure that the reaction proceeds smoothly and the product selectivity is good.
Second, you can start from 5-bromo-2-methylpyridine. First, 5-bromo-2-methylpyridine is oxidized. The commonly used oxidizing agents are potassium permanganate, potassium dichromate, etc. In an alkaline medium, potassium permanganate reacts with 5-bromo-2-methylpyridine. After a series of oxidation steps, the methyl group is oxidized to a carboxyl group, resulting in 5-bromopyridine-2-carboxylic acid. This process requires strict control of the reaction conditions, such as the proportion of reactants, reaction temperature and time, to avoid side reactions such as excessive oxidation.
Third, using 2-amino-5-bromopyridine as raw material, diazotization is first carried out, and then hydrolysis can also synthesize the target product. 2-amino-5-bromopyridine is reacted with sodium nitrite under acidic conditions to form a diazonium salt. Subsequently, the diazonium salt is hydrolyzed, and the diazonium group is replaced by a hydroxyl group, which is then converted into a carboxyl group through oxidation and other steps, and finally 5-bromopyridine-2-carboxylic acid is obtained. In this route, the conditions of the diazotization reaction are quite critical, and factors such as temperature and acid concentration need to be controlled to ensure the stability of the diazotide salt and the smooth progress of the reaction.
All this synthesis method has its own advantages and disadvantages, and it is necessary to choose carefully according to the actual situation, such as the availability of raw materials, cost, and product purity requirements.

5-Bromopyridine-2-carboxylic acid, the price of this product varies from time to time in the market, and also varies with quality, supply and demand. Looking at the market conditions of the past, the price per gram of high-quality products may range from tens to hundreds of yuan. If its purity is extremely high, it is suitable for high-end scientific research, and the price must be high; while the purity is slightly lower, it is used for general industrial preparation, and the price is slightly cheaper.
In the past, due to the development of new drugs by a pharmaceutical company, the demand for 5-bromopyridine-2-carboxylic acid increased sharply, causing its price to rise in a short time. Or because the supply of the place of origin is abundant, the market is flooded with this product, and the price is going down. And the pricing of different merchants is also different. The goods of large merchants are often of high quality and high price; the goods sold by small merchants may be slightly lower due to cost considerations.
If you want to know the exact market price at the moment, you should consult the chemical raw material supplier, or visit the relevant chemical product trading platform, so that you can get real-time and accurate prices to meet your needs.

5-Bromopyridine-2-carboxylic acid, this is an organic compound. Its physical and chemical properties are unique, let me come one by one.
Looking at its properties, at room temperature, it is mostly in the state of white to quasi-white crystalline powder. This state is conducive to storage and use, and also shows specific advantages in many chemical reactions.
When it comes to solubility, it has a certain solubility in organic solvents, such as dichloromethane, N, N-dimethylformamide (DMF). However, in water, the solubility is relatively limited. This solubility characteristic is of great significance in the extraction and separation steps of organic synthesis. For example, in a reaction system, if you want to separate the product containing 5-bromopyridine-2-carboxylic acid, you can choose a suitable solvent for extraction according to its solubility in different solvents to achieve the purpose of separation and purification.
The melting point of 5-bromopyridine-2-carboxylic acid is usually within a specific range. Accurate melting point data is an important indicator for identifying the purity of this compound. If the purity is high, the melting point range is narrow and close to the theoretical value; if it contains impurities, the melting point may decrease and the melting point range will also become wider.
Its chemical properties are active, and carboxyl groups can participate in many reactions. If it is catalyzed by acid with alcohols, it can undergo esterification reaction to generate corresponding ester compounds. This ester product may have a unique aroma and can be used in the fragrance industry; or in drug synthesis, it can be used as a key intermediate to further react to construct complex drug molecular structures. The bromine atom is also an activity check point, which can introduce various functional groups through nucleophilic substitution reactions. In the design of organic synthesis routes, this reaction is often a key step in building new carbon-heteroatom bonds, expanding the structural diversity of molecules, and laying the foundation for the preparation of organic materials with different functions, drugs, etc.

5-Bromopyridine-2-carboxylic acid is a chemical substance. When storing and transporting, many matters must be paid attention to.
First word storage. This material or lively, should be avoided by high temperature and fire sources to prevent unexpected changes. It should be placed in a cool, dry and well-ventilated place, so that its properties can be kept stable. And because it may be sensitive to air and moisture, it is necessary to keep it sealed. If the storage device is not strict, moisture intrudes, or causes it to hydrolyze, and lose its original characteristics. In addition, this product may be in danger of phase transformation with other things, so it should not be stored with things that are contrary to their properties, and should be separated to prevent interaction and damage their quality.
As for transportation. Also need to be cautious. The container for transportation must be strong and sealed to prevent leakage. When handling, handle it with care and do not drop it to avoid damage to the container. At the same time, the transporter must understand its characteristics and hazards, and know the emergency response methods. If there is any leakage during the journey, it must be able to respond quickly to reduce the harm. And the transportation environment should also be paid attention to, the temperature and humidity should be appropriate, and it should not be allowed to be exposed to harsh conditions.
All of these, the storage and transportation of 5-bromopyridine-2-carboxylic acid are urgent matters, and must be followed carefully to ensure its safety.