5-Bromo-pyridine-2-carboxylic acid methylamide

5-Bromo-pyridine-2-carboxylic acid formamide has a wide range of uses and is of great value in various fields.
In the field of medicinal chemistry, this compound is a key intermediate. Chemists use it as a starting material and can construct complex drug molecules through various organic synthesis methods. Because of its structure of pyridine and amide, it endows unique chemical properties and biological activities, and can participate in many reactions to create drugs with specific pharmacological activities. The research and development of drugs such as antibacterial, anti-inflammatory, and anti-tumor drugs may be based on it.
In the field of materials science, 5-bromo-pyridine-2-carboxylic acid formamide can also be used. It can be chemically modified to introduce specific functional groups to prepare materials with special properties. It may affect the optical and electrical properties of materials, such as for the preparation of organic photoelectric materials, used in Light Emitting Diode, solar cells and other devices, contributing to the development of materials science.
Furthermore, in the study of organic synthetic chemistry, it serves as an important building block for chemists to explore novel reaction paths and synthesis strategies. Due to the activity of bromine atoms in its structure, it can trigger various reactions such as nucleophilic substitution and coupling, providing an opportunity for the innovative development of organic synthetic chemistry, and helping researchers to explore the synthesis methods and routes of new compounds.
In summary, 5-bromo-pyridine-2-carboxylic acid formamide plays an important role in many fields such as medicine, materials and organic synthesis, providing key support for the progress and development of related fields.

5-Bromo-pyridine-2-carboxylic acid formamide, this is an organic compound. Looking at its physical properties, under normal temperature and pressure, it is often in a solid state, but the specific properties are also affected by many factors such as purity. If the purity is extremely high, or it is a white to off-white crystalline powder, if it contains impurities, the color may change, or even slightly yellow and other variegated colors.
Its melting point is one of the key physical parameters, about a specific temperature range. This value is very important in the identification and purification of compounds. Due to the specific groups in the molecular structure, its solubility is unique. In common organic solvents, such as methanol, ethanol, dichloromethane, etc., it may have certain solubility. In methanol, the polarity of methanol interacts with some groups of the compound, or it can be mutually soluble in a certain proportion. However, in water, due to the hydrophobicity of the overall structure, the solubility is poor.
Furthermore, its stability is also a key point of concern. Under conventional environmental conditions, without the influence of special chemical reagents or severe physical conditions, the structure is relatively stable. When exposed to high temperature, strong oxidants or specific catalysts, chemical reactions may occur, resulting in structural changes. This compound has unique physical properties due to the combination of specific atoms and groups, and is widely used in organic synthesis and other fields.

The chemical synthesis of 5-bromopyridine-2-carboxylic acid formamide is a very important topic in the field of organic synthesis. There are various synthesis paths and common methods, which can be initiated by 5-bromopyridine-2-carboxylic acid.
First, the esterification reaction of 5-bromopyridine-2-carboxylic acid and methanol under acid catalysis can obtain 5-bromopyridine-2-carboxylic acid methyl ester. This reaction requires attention to the reaction temperature and catalyst dosage. If the temperature is too high or the catalyst is excessive, side reactions may occur. < Br >
5-bromopyridine-2-carboxylic acid methyl ester is reacted with ammonia to achieve amidation. In this step, the amount of ammonia and the reaction time are extremely critical. If the amount of ammonia is insufficient, the reaction is difficult to complete; if the reaction time is too short, the product yield is low. Suitable solvents, such as dichloromethane and tetrahydrofuran, can also be selected to promote the reaction.
Another method can activate 5-bromopyridine-2-carboxylic acid first, such as conversion to acid chloride, and then react with methylamine to form the target product 5-bromopyridine-2-carboxylic acid formamide. In the preparation of acyl chloride, commonly used chlorination reagents such as dichlorosulfoxide are highly reactive and need to be handled cautiously at low temperature, and the reaction tail gas needs to be properly handled.
During the synthesis process, the separation and purification of the product cannot be ignored. Column chromatography and recrystallization are commonly used to obtain high-purity 5-bromopyridine-2-carboxylic acid formamide. During column chromatography, a suitable eluent should be selected; for recrystallization, an appropriate solvent should be selected, which needs to be carefully explored according to the characteristics of the product.

5-Bromo-pyridine-2-carboxylic acid formamide is a chemical substance. When storing and transporting, many matters must be paid attention to.
First words storage, this chemical substance should be placed in a cool and dry place. If it is in a warm and humid environment, or cause its properties to mutate, affecting its quality. Just like the ancients, it is necessary to choose a dry and cool place to prevent the utensils from spoiling. It is also necessary to isolate fire and heat sources, because it may be flammable. In case of open fire and hot topic, there will be many dangers, just like flammable firewood, and near fire will burn.
Furthermore, the storage place should be separated from oxidants, acids, bases, etc. This is due to the interaction of different chemicals, or a violent reaction, if water and fire are incompatible, contact will be chaotic. And the storage area must be prepared with suitable materials to contain leaks, so as to prevent accidental leakage, and can be disposed of in time, so as not to spread the harm.
As for transportation, it is necessary to ensure that the packaging is complete and the loading is secure before transportation. If the packaging is damaged, it may cause leakage during transportation, causing danger. Just like a long-distance load, the package is not solid, and the goods are easy to be scattered. During transportation, the speed of the vehicle should not be too fast, nor should it be braked suddenly to prevent vibration and collision, resulting in packaging damage. And the transportation vehicle should be equipped with the corresponding variety and quantity of fire equipment and leakage emergency treatment equipment to prepare for emergencies.
The escort personnel should pay close attention to the whole transportation process. If they are escorted in the past, they will not dare to slack off for a while. If there is any abnormality, they will be disposed of immediately, so as to ensure the safety of 5-bromo-pyridine-2-carboxylic acid formamide during storage and transportation.

The market price range of 5-bromo-pyridine-2-carboxylic acid formamide fluctuates due to various factors. In the chemical market, raw materials, supply and demand, and production processes all determine its price.
Let's talk about the raw materials first, 5-bromo-pyridine-2-carboxylic acid and methylamine are the main raw materials. If the production of 5-bromo-pyridine-2-carboxylic acid is small and the demand is high, the price will rise, resulting in an increase in the cost and price of 5-bromo-pyridine-2-carboxylic acid formamide. The same is true for methylamine. Market fluctuations affect its price and affect the finished product.
The supply and demand relationship has a great impact. The pharmaceutical, material science and other industries have a strong demand for 5-bromo-pyridine-2-carboxylic acid formamide, but the supply is limited, and the price rises; if the demand is weak and the supply exceeds the demand, the price will drop. For example, pharmaceutical companies need a large amount of this compound to develop new drugs, and the demand increases sharply, and the price will rise accordingly.
The complexity of the production process is related to the cost and price. The process is advanced and mature, the cost can be reduced, and the price may be more accessible to the people; if the process is complicated, the energy consumption is high, the yield is low, the cost is high, and the price is also high. The successful development of new production technologies will increase the yield and reduce the
According to past market data and market conditions, the price ranges from hundreds to thousands of yuan per kilogram. When ordinary quality and quantity are large, it can cost hundreds of yuan per kilogram; when high purity and special purpose, it can reach thousands of yuan per kilogram. However, the market is changing, and the actual price needs to be determined by chemical product suppliers in detail, according to specific quality, purchase volume, transaction time, etc.