5 Bromo 6 Fluoro Pyridine 3 Carboxylic Acid
pyridine pyrrole pyrazine piperidine piperazine

5-bromo-6-fluoro-pyridine-3-carboxylic acid

    Specifications

    HS Code

    830927

    Name 5-bromo-6-fluoro-pyridine-3-carboxylic acid
    Molecular Formula C6H3BrFNO2
    Molecular Weight 220.00
    Appearance Solid (predicted)
    Boiling Point 324.1±37.0 °C at 760 mmHg (predicted)
    Melting Point 173 - 177 °C
    Density 1.909±0.06 g/cm3 (20 °C, 760 mmHg) (predicted)
    Pka 2.65±0.10 (predicted)
    Solubility Soluble in organic solvents like DMSO, DMF
    Flash Point 149.8±26.5 °C (predicted)
    Cas Number 1211546-73-4

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    General Information
    Where to Buy 5-bromo-6-fluoro-pyridine-3-carboxylic acid in China?
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    Frequently Asked Questions

    As a leading 5-bromo-6-fluoro-pyridine-3-carboxylic acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 5-bromo-6-fluoropyridine-3-carboxylic acid?
    5-Hydroxy-6-aldehyde-3-pyridinecarboxylic acid, an organic compound. Its main uses are quite extensive. In the field of medicine, it may be used as an intermediate for drug synthesis. Because pyridinecarboxylic acid compounds often have various biological activities, such as participating in the regulation of human metabolism, etc., by means of these compounds, drugs with specific curative effects can be synthesized, or used to treat certain diseases, such as the intervention of specific metabolic disorders.
    In the field of materials science, it may serve as a key raw material for the synthesis of functional materials. With its unique molecular structure, it can participate in polymerization reactions under specific conditions, so as to construct materials with special properties, such as in the preparation of materials with specific requirements for chemical stability and optical properties.
    At the level of scientific research, because of its special chemical structure, it can be used as a model compound to help scientists explore the mechanism of organic chemical reactions. By studying the various reactions it participates in, it can better clarify the reaction path and the effect of reaction conditions on the product, providing an important basis for the development of organic chemistry theory.
    Because of the special combination of aldehyde and hydroxyl and pyridine rings, in the field of organic synthetic chemistry, it can be used as a key connection fragment to construct more complex organic molecules, expand the structural diversity of organic compounds, and provide more possibilities for new drug research and development, new material creation, etc. In short, 5-hydroxyl-6-aldehyde-3-pyridinecarboxylic acid has important potential application value in many fields. With the continuous deepening of scientific research, its use may be more widely expanded and excavated.
    What are the synthesis methods of 5-bromo-6-fluoropyridine-3-carboxylic acid?
    The synthesis of 5-hydroxyl-6-aldehyde-3-pyridinic acid is related to the technology of chemical synthesis and is an important topic studied by chemists.
    To synthesize this compound, one of the methods can use the conventional route of organic synthesis. First take a suitable pyridine derivative as the starting material, and introduce the required functional group through a specific substitution reaction. If pyridine is used as a group, a halogen atom is introduced at a specific position in the pyridine ring through a halogenation reaction. This halogen atom can be used as an activity check point for subsequent reactions.
    Then, through a nucleophilic substitution reaction, a hydroxyl-containing group is introduced to construct the 5-hydroxyl structure. Nucleophiles such as alkoxides or phenols can be selected to react with halogenated pyridine derivatives to promote the access of hydroxyl groups.
    As for the formation of 6-aldehyde groups, oxidation reactions can be used. Select appropriate oxidants, such as mild Dess-Martin oxidants, to oxidize specific alcohol precursors to aldehyde groups. Pre-construct groups with oxidizable aldehyde groups at suitable positions on the pyridine ring, such as alcohol hydroxyl groups, and then through this oxidation step, 6-aldehyde groups can be obtained.
    The construction of 3-pyridine acids can be achieved by means of carboxylation reactions. Using a pyridine derivative containing a suitable substituent as a substrate, it reacts with carbon dioxide under specific catalysts and reaction conditions, such as in the presence of a transition metal catalyst (such as a palladium catalyst), under the action of a suitable solvent and base, to achieve the carboxylation of the 3-position, thereby obtaining the 3-pyridine acid structure. Through such a series of reaction steps, carefully adjusting the reaction conditions, including temperature, solvent, catalyst and other factors, 5-hydroxyl-6-aldehyde-3-pyridinic acid can be successfully synthesized.
    Or there may be other synthesis strategies, such as biosynthesis. The synthesis of the target compound is achieved through the process of biocatalysis using specific microorganisms or enzymes. Some microorganisms or enzymes have a high degree of selectivity and catalytic activity, and can precisely construct the required functional groups and molecular structures under mild reaction conditions. However, the path of biosynthesis requires in-depth understanding of the biological system, screening of suitable biocatalysts, and optimization of biological reaction conditions to achieve effective synthesis.
    What are the physical properties of 5-bromo-6-fluoropyridine-3-carboxylic acid?
    5-Hydroxy-6-heptanoenoic acid is an organic compound with unique physical properties. It is mostly liquid at room temperature, and has corresponding characteristics due to the specific functional groups such as carboxyl and alkenyl groups.
    In terms of its solubility, the carboxyl group is a hydrophilic group, resulting in a certain solubility in water. However, because the molecule contains longer carbon chains, its hydrophobicity also exists, so its solubility in water is not very high. Compared with small molecule carboxylic acids, its solubility is slightly inferior. In common organic solvents such as ethanol and ether, 5-hydroxy-6-heptanoenoic acid has good solubility, because organic solvents can interact with molecules to form van der Waals forces, etc., to help it dissolve.
    When it comes to boiling point, the boiling point of 5-hydroxy-6-heptaenoic acid is relatively high due to the presence of hydrogen bonds (hydroxyl groups derived from carboxyl groups) between molecules, coupled with the van der Waals force of the carbon chain. Hydrogen bonds make the intermolecular bonds more tightly bound, and higher energy is required to overcome the intermolecular forces to make it boil.
    Its density is slightly higher than that of water. Due to the relatively tight structure of carbon atoms and oxygen atoms in the molecule, the mass is concentrated, resulting in a unit volume mass greater than that of water.
    The appearance of 5-hydroxy-6-heptaenoic acid is usually colorless to light yellow liquid, which is related to the molecular structure and electronic transition characteristics. The distribution of electron clouds in the molecule makes the light of specific wavelengths absorb and reflect, showing this color. In addition, the presence of alkenyl groups gives them certain reactivity and can participate in reactions such as addition; carboxyl groups make compounds acidic, capable of neutralizing with bases, etc. These chemical properties are also related to physical properties, affecting their state and behavior in different environments.
    What is the market price of 5-bromo-6-fluoropyridine-3-carboxylic acid?
    I have heard what you have inquired about, but it is the market price of Panax notoginseng acid in the five and six grades. Those who are five and six grades, or the category of things, Panax notoginseng acid, also belong to this category. However, in order to know its market price, you need to look at various factors.
    The supply and demand of the city is the key. If the demand for Panax notoginseng acid in the five and six grades is abundant, but the supply is not enough, the price will rise; if the supply exceeds the demand, the price will be suppressed.
    The changing times also affect the price. When the time is prosperous, business is prosperous, and people compete for purchases, the price will rise easily; if the time is bad, the business route is difficult, and the buyer is scarce, the price will not be high.
    The proximity of the place of origin also affects its price. If the place of origin is close, the cost of transportation will be saved, and the price will be cheap; if the place of origin is far away, the cost of transportation will be huge, and the price will be high or high.
    The quality is good or bad, and the price is related to the amount of price. If the quality of the five-and-six-percent notoginseng acid is good, and everyone is attracted to it, the price will be considerable; if the quality is ordinary, the price will be limited.
    Therefore, if you want to understand the market price of the five-and-six-percent notoginseng acid, you must comprehensively investigate it. Only by consulting the cities, or considering the market records, can you get a rough idea. However, the market is not constant, and the price is also not
    What are the storage conditions for 5-bromo-6-fluoropyridine-3-carboxylic acid?
    If the five-to-six-to-six-to-be-stored parts of triformic acid are susceptible to the influence of general factors due to triformic acid activity, so care should be taken.
    The first one is the most important. It is best to use it in a cool place to avoid high temperatures. If it is in a high environment, triformic acid or the cause of decomposition, its chemical properties and soil are easy to change. Usually, it is best to use 2 to 8 degrees Celsius. This degree can ensure the determination of triformic acid, and it may be transformed.
    For the second time, light should not be ignored. Triformic acid should be stored in the dark to avoid direct exposure to light. Light or the ability to stimulate triformic acid molecules can cause photochemical reaction, causing its composition to change. Therefore, light-shielding materials, such as brown glass bottles, should be used for the device, which can block light and reduce the property of triformic acid.
    Furthermore, attention should also be paid to the degree of resistance. Triformic acid has water absorption. If the degree of resistance to the environment is high, triformic acid or absorption will cause the degree of degradation, and the absorption will be reduced or promoted. Therefore, it is better to keep the dryness in the hidden area, and it can be placed next to the dryness to control the degree of the environment.
    In addition, the material of the device is also studied. Triformic acid is corrosive, and it should not be used for materials that are easily corroded. It is appropriate to use corrosion-resistant materials such as glass and non-corrosive materials, and the device should be well-dense to prevent the triformic acid from connecting with external objects, causing the reaction, and preventing its loss.
    Therefore, the five-to-six-to-the-triformic acid must be kept cool, dry, and protected from light, and it must be stored securely with the combined device. Only by controlling the degree, degree, and light can the triformic acid be preserved and its function can be developed.