5-BROMO-6-FLUORO-1H-PYRROLO[2,3-B]PYRIDINE

5-Bromo-6-fluoro-1H-pyrrolido [2,3-b] pyridine is an organic compound. It has a wide range of uses in the field of medicinal chemistry and is often a key intermediate to assist in the synthesis of compounds with specific biological activities. In the process of many drug development, the compound has a unique structure and can be chemically modified to introduce different functional groups to change the molecular properties of the drug, such as solubility, stability and affinity with targets, in order to achieve specific therapeutic effects.
In the field of materials science, it also has applications. In the synthesis of some organic optoelectronic materials, it can be used as a basic structural unit to endow the material with special electrical and optical properties, such as adjusting the energy band structure of the material and improving its photoelectric conversion efficiency. It is used in organic Light Emitting Diode (OLED), solar cells and other devices.
In the field of pesticide chemistry, 5-bromo-6-fluoro-1H-pyrrolido [2,3-b] pyridine also has potential value. Or it can be reasonably designed to prepare pesticide products with high insecticidal, bactericidal or herbicidal activities, providing assistance for pest control and weed control in agricultural production. In addition, in the study of organic synthesis chemistry, as a characteristic substrate, it can participate in a variety of chemical reactions, providing an effective way for the construction of new complex organic molecules, promoting the development and innovation of organic synthesis methodologies, and expanding the structural diversity of organic compounds.

The synthesis methods of 5-bromo-6-fluoro-1H-pyrrolido [2,3-b] pyridine are different and each has its own subtlety.
First, bromine and fluorine atoms can be introduced by halogenation reaction from compounds containing pyridine structure. If a suitable pyridine derivative is used as the starting material, under specific reaction conditions, the reaction temperature, time and reagent dosage should be carefully adjusted by using halogenated reagents. During the halogenation process, the selectivity of the reaction check point needs to be precisely controlled to ensure that the bromine and fluorine atoms fall exactly as required, at the 5th and 6th positions of the target, respectively. This method requires quite strict reaction conditions, and the activity and selectivity of the halogenated reagent will have a significant impact on the purity and yield of the product.
Second, the construction of the pyrrolidine skeleton is taken as the idea. The skeleton can be built gradually through a multi-step reaction, and then halogenated. First, a suitable starting material is selected, and the basic structure of pyrrolidine is successfully constructed through condensation, cyclization and other reactions. Then, according to the characteristics of the halogenation reaction, bromine and fluorine are introduced at the 5th and 6th positions. Although this path is a little complicated, it has better control over the accuracy of skeleton construction and the selectivity of halogenation check points, which is conducive to obtaining high-purity target products.
Third, with the help of the reaction strategy of transition metal catalysis. With suitable metal catalysts and specific ligands, the reaction of substrates is catalyzed to achieve the precise introduction of bromine and fluorine atoms. This method relies on the careful screening of catalysts and ligands, as well as the careful optimization of reaction conditions. The activity and selectivity of transition metal catalysts play a decisive role in the reaction, which can effectively improve the efficiency of the reaction and the selectivity of the product, providing an efficient and accurate way for the synthesis of 5-bromo-6-fluoro-1H-pyrrolido [2,3-b] pyridine.
The above methods each have their own strengths. In actual synthesis, it is necessary to consider the availability of starting materials, the ease of control of reaction conditions, the purity and yield requirements of the product, and many other factors. Only by making a careful choice can the ideal synthetic effect be achieved.

5-Bromo-6-fluoro-1H-pyrrolido [2,3-b] pyridine is one of the organic compounds. Its physical and chemical properties are quite unique and have attracted much attention in the field of chemical research.
Looking at its physical properties, under room temperature and pressure, this substance is often in a solid state, but its specific appearance may vary slightly depending on the purity and preparation method, or it is a white to light yellow crystalline powder. Its melting point is also one of the key physical properties, and the specific melting point value is of great significance for the identification and purification of this compound. Sadly, the exact melting point geometry is not yet known.
As for solubility, the performance of this substance in organic solvents is particularly important. Generally speaking, it has some solubility in common organic solvents such as dichloromethane, N, N-dimethylformamide (DMF), which makes researchers rely on the construction, separation and purification steps of the reaction system. The solubility in water is relatively limited, which is also in line with the commonality of many nitrogen-containing heterocyclic aromatic compounds.
On its chemical properties, the presence of bromine and fluorine atoms in 5-bromo-6-fluoro-1H-pyrrolido [2,3-b] pyridine gives it unique reactivity. Bromine atoms are more active and can participate in a variety of nucleophilic substitution reactions. For example, in the presence of appropriate bases and catalysts, it can react with various nucleophiles such as alcohols and amines to generate corresponding substitution products, which provides an effective way to construct complex organic molecular structures. The introduction of
fluorine atoms not only affects the electron cloud distribution of molecules, but also enhances their chemical stability and biological activity. In many pharmaceutical chemistry and material science studies, fluorinated compounds often exhibit unique properties. The conjugated system of the pyridine ring of 5-bromo-6-fluoro-1H-pyrrolido [2,3-b] pyridine and the pyrrole ring makes it have certain aromatic properties and can undergo typical reactions of aromatic compounds such as electrophilic substitution, which lays the foundation for further structural modification and functionalization.

I look at your question, and I am inquiring about the price range of 5-bromo-6-fluoro-1H-pyrrolido [2,3-b] pyridine in the market. However, the price of this chemical often changes for many reasons, and it is difficult to determine the number.
First, the price is different for different suppliers. Large merchants and small merchants sell this product at different prices due to different purchasing channels and operating costs. Large merchants may have the best price due to large quantities, while small merchants may have different prices due to flexibility.
Second, the quantity also affects the price. If the purchase quantity is small, the unit price may be high; if the purchase quantity is large, the merchant may give a discount, and the price will become lower.
Third, the change of market conditions is also the key. If the price of raw materials rises or the demand increases greatly, the price of this product will also rise; conversely, if the raw materials are abundant and the demand is weak, the price may drop.
As far as I know, this chemical is not well known to the public and is used in the field of special chemicals. It may be difficult to find in the market, and even if there is one, the price fluctuates greatly. Usually, small-scale retail sales range from tens to hundreds of yuan per gram; if large-scale wholesale, per kilogram or thousands of yuan, then this is only an approximate number, not the exact value. To know the exact price, you need to consult the chemical raw material suppliers in detail and compare the quotations of each company in order to obtain a more accurate price.

5-Bromo-6-fluoro-1H-pyrrolido [2,3-b] pyridine is a very important chemical substance. Its storage conditions are of great significance, which is related to the stability and quality of the substance. When this substance is stored, the first environment must be dry. Because moisture can easily cause many chemical reactions, causing the substance to deteriorate. If the storage environment is humid, water molecules may interact with 5-bromo-6-fluoro-1H-pyrrolido [2,3-b] pyridine, or cause its structure to change and its activity to be impaired. Therefore, it is necessary to choose a dry place, such as a storage cabinet equipped with desiccant, to maintain the dryness of the environment.
Secondly, temperature control cannot be ignored. This substance should be stored in a low temperature environment, usually 2-8 ° C. High temperature can easily cause molecular movement to intensify, making the chemical properties of the substance tend to be active, which can lead to adverse reactions such as decomposition and polymerization. If the temperature is too high, the chemical bond of 5-bromo-6-fluoro-1H-pyrrolido [2,3-b] pyridine may break or form other impurities, which affect its purity and properties.
Furthermore, light also affects it. Avoid direct exposure of the substance to light, especially strong light. Light can provide energy, induce luminescent chemical reactions, and cause the substance to deteriorate. Therefore, it is advisable to use a light-shielding container, such as a brown glass bottle, when storing to block light and reduce the risk of photochemical reactions.
In addition, attention should be paid to isolation from other substances during storage. 5-Bromo-6-fluoro-1H-pyrrolido [2,3-b] pyridine or chemically react with certain substances, so it should not be stored with substances with strong oxidation, strong reduction or strong acidity and alkalinity to prevent interaction and deterioration. Only by following the above storage requirements can the quality and stability of 5-bromo-6-fluoro-1H-pyrrolido [2,3-b] pyridine be ensured for subsequent experiments or production.