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What is the main use of 5-Bromo-6-chloro-2- (trifluoromethyl) pyridine?
5-Bromo-6-chloro-2- (trifluoromethyl) pyridine is also an organic compound. It has a wide range of main uses and is often a key intermediate in the field of medicinal chemistry. The unique structure of the Gainpyridine ring gives this compound special chemical activity and stability, and is suitable for the synthesis of many biologically active drug molecules.
In pharmaceutical research and development, it may be used to prepare antibacterial drugs. Bacterial cell wall synthesis, protein synthesis and other key processes can be its target. By introducing it into the molecular structure of drugs through specific chemical reactions, it is expected to improve the antibacterial efficacy and selectivity of drugs, and can inhibit or kill Gram-positive and negative bacteria.
In the field of pesticide chemistry, it is also an important synthetic raw material. Insecticides, fungicides, etc. can be prepared. In terms of insecticides, they can use their unique chemical properties to interfere with the physiological functions of the nervous system and respiratory system of insects, and achieve the purpose of efficient insecticide. They are relatively friendly to the environment, have good degradability, and have little residue. It is of great significance for the prevention and control of modern agricultural diseases and pests.
In the field of materials science, this compound may participate in the synthesis of functional materials. For example, photoelectric materials, their special electronic structure may affect the photoelectric properties of materials, so that the materials exhibit excellent characteristics in light absorption, charge transport, etc., providing a new way for the research and development of organic Light Emitting Diode (OLED), solar cells and other
In summary, 5-bromo-6-chloro-2 - (trifluoromethyl) pyridine has important uses in many fields such as medicine, pesticides, and materials, which cannot be ignored, promoting technological progress and innovation in various fields.
What are the synthesis methods of 5-Bromo-6-chloro-2- (trifluoromethyl) pyridine
The method of synthesizing 5-bromo-6-chloro-2-trifluoromethyl-pyridine is described in detail.
One method can also be started from a compound containing a pyridine ring, and bromine and chlorine atoms can be introduced through a halogenation reaction. If a suitable pyridine derivative is first taken, a bromine atom is substituted for a specific position of the hydrogen atom on the pyridine ring with a bromine reagent, such as bromine ($Br_2 $), under suitable reaction conditions, or in the presence of a catalyst, to obtain a bromine-containing pyridine intermediate. Then, a chlorination reagent, such as thionyl chloride ($SOCl_2 $) or chlorine gas ($Cl_2 $), is selected. In a suitable reaction system, the chlorine atom is also connected to the pyridine ring, and the final product is 5-bromo-6-chloro-2 - (trifluoromethyl) pyridine.
Another method can start from the pyridine substrate containing trifluoromethyl. First, under specific reaction conditions, at a specific check point of the pyridine ring, a bromine atom is introduced by appropriate bromination means to form an intermediate product. Then, the chlorine atom is introduced to the desired position by chlorination method, which can also achieve the purpose of synthesis. In this process, the reaction conditions, such as temperature, solvent, catalyst, etc., need to be carefully selected to ensure the selectivity and yield of the reaction.
Furthermore, the strategy of gradually constructing the pyridine ring can be considered. The key intermediates containing bromine, chlorine and trifluoromethyl are first prepared, and then the pyridine ring structure is constructed by cyclization reaction to synthesize 5-bromo-6-chloro-2 - (trifluoromethyl) pyridine. In this approach, the choice of cyclization conditions is crucial, such as the proportion of reactants, reaction temperature, reaction time, and the type of catalyst used, all of which have a significant impact on the success or failure of the reaction and the purity and yield of the product.
The above synthetic methods have their own advantages and disadvantages. In practical application, it is necessary to comprehensively consider factors such as the availability of raw materials, reaction costs, ease of operation, and the purity and yield of the target product, and choose the best one.
What are the physical properties of 5-Bromo-6-chloro-2- (trifluoromethyl) pyridine
5-Bromo-6-chloro-2- (trifluoromethyl) pyridine is an important compound in the field of organic chemistry. Its physical properties are unique and of great significance to many aspects such as organic synthesis.
Looking at its appearance, under room temperature and pressure, this compound is mostly colorless to light yellow liquid, with pure color, uniform texture, and no signs of significant impurities mixing. This appearance characteristic makes it easy to identify and handle in various experiments and industrial operations, laying an intuitive foundation for subsequent applications.
When it comes to odor, the compound emits a specific irritating odor. Although this odor is not strong and pungent to the point of being unbearable, it cannot be ignored. During actual operation, special attention should be paid to the emission of odor to take appropriate protective measures to ensure the health and safety of operators. This odor characteristic reflects its chemical activity from the side, suggesting that it may exhibit specific reactivity and selectivity in chemical reactions.
In terms of boiling point, the boiling point of 5-bromo-6-chloro-2 - (trifluoromethyl) pyridine has been accurately determined to be within a certain temperature range. This boiling point characteristic is crucial for its separation, purification and reaction control under different temperature conditions. With the help of boiling point difference, classical separation methods such as distillation can be used to precisely separate it from the mixture to obtain high-purity products, which meet the strict requirements of purity in different application scenarios.
In terms of solubility, this compound exhibits certain solubility properties in organic solvents. Organic solvents such as common ethanol and dichloromethane have good solubility to 5-bromo-6-chloro-2- (trifluoromethyl) pyridine. In water, its solubility is relatively low. This solubility property provides an important reference for the selection of solvents in organic synthesis reactions. When designing a synthesis route, a suitable solvent can be selected according to its solubility, the reaction conditions can be optimized, and the reaction efficiency and product yield can be improved.
Density is also one of its important physical properties. The compound has a specific density value, which is of great significance for accurate measurement and material ratio. In the actual production and experimental process, accurate material ratio is the key factor to ensure the smooth progress of the reaction and obtain the ideal product. By precisely controlling the dosage of 5-bromo-6-chloro-2 - (trifluoromethyl) pyridine, combined with its density characteristics, it can effectively avoid side reactions and product quality problems caused by improper dosage.
In summary, the physical properties of 5-bromo-6-chloro-2 - (trifluoromethyl) pyridine are related in various aspects, from appearance, odor, boiling point, solubility to density, which together constitute its unique physical property system, providing a solid foundation for its application in many fields such as organic synthesis and drug development. An in-depth understanding and accurate grasp of these physical properties is an important prerequisite for giving full play to their chemical value and achieving efficient application.
What are the chemical properties of 5-Bromo-6-chloro-2- (trifluoromethyl) pyridine
5-Bromo-6-chloro-2- (trifluoromethyl) pyridine, this is a kind of organic compound. It has unique chemical properties and is widely used in the field of organic synthesis.
In terms of chemical properties, the presence of halogen atoms bromine and chlorine makes the compound exhibit the typical characteristics of halogenated hydrocarbons. Bromine and chlorine are highly active and can participate in many nucleophilic substitution reactions. In this reaction, nucleophiles can attack the carbon atoms attached to the halogen atoms, and the halogen atoms leave to form new organic compounds. This property makes 5-bromo-6-chloro-2- (trifluoromethyl) pyridine an important intermediate for the construction of complex organic molecules.
Furthermore, the introduction of trifluoromethyl confers special properties to the compound. Trifluoromethyl has strong electron absorption and can significantly affect the electron cloud density of the pyridine ring. This electronic effect not only alters the chemical activity of the pyridine ring, but also affects other groups connected to it. For example, it can change the check point of the electrophilic substitution reaction on the pyridine ring, affecting the regioselectivity of the reaction.
In addition, due to the presence of trifluoromethyl, the compound also has certain stability and hydrophobicity. Stability allows it to maintain structural integrity under some reaction conditions, and hydrophobicity plays a role in some reactions involving phase transfer or systems that are immiscible with water.
5-Bromo-6-chloro-2 - (trifluoromethyl) pyridine plays an indispensable role in the field of organic synthetic chemistry, whether it is the construction of new drug molecules or the development of functional materials. Its unique chemical properties provide many possibilities for the development of organic chemistry.
What is the price range of 5-Bromo-6-chloro-2- (trifluoromethyl) pyridine in the market?
I have not seen the exact price of 5-bromo-6-chloro-2- (trifluoromethyl) pyridine on the market. The price range of this compound often varies with quality, quantity, seller, and season. If you are looking for it in the chemical raw material market, the price is high if the quantity is small and pure; if the quantity is large and pure, the price is low.
The price of past chemical materials of Guanfu, such specialized products, in the experimental dosage (several grams to tens of grams), the price per gram may be in the tens to hundreds of gold. If it is used in industry, buy it in bulk (kilogram level), and the price per kilogram may be between thousands of gold and 10,000 gold. However, this is only a guess. The chemical market conditions are ever-changing, and the price of raw materials changes with supply and demand, production conditions, and political regulations. To get a confirmed price, consult chemical suppliers, traders, or explore chemical e-commerce platforms to get a near-real price.