5-bromo-3H-imidazo[4,5-b]pyridine

5-Bromo-3H-imidazo [4,5-b] pyridine is an organic compound with unique chemical properties.
This compound contains bromine atoms, and the electronegativity of bromine is strong, which changes the polarity of the molecule and affects its physical and chemical behavior. Bromine atoms are highly active and easily involved in nucleophilic substitution reactions. They can be used as key intermediates in the field of organic synthesis to construct a variety of compounds and react with nucleophilic reagents to form new carbon-heteroatom bonds.
Its imidazolopyridine structure gives unique electronic properties, and the conjugate system affects the distribution of electron clouds, making this structure have certain aromaticity and stability. The nitrogen atom in this structure has a lone pair of electrons, which can be used as an electron donor, participate in coordination chemistry, and form complexes with metal ions. It is widely used in the fields of catalysis and materials science.
In addition, the hydrogen atom at the 3H position of this compound has a certain acidity. Under suitable conditions, it can be removed by the base to generate corresponding anions, participate in subsequent reactions, and provide a variety of reaction paths for organic synthesis.
In terms of physical properties, it is affected by molecular polarity and relative molecular mass, and its melting point, boiling point, and solubility have specific manifestations. Polarity is related to intermolecular forces, which affect the dissolution status in different solvents. Understanding these properties is crucial for separation, purification, and screening of reaction conditions. In conclusion, 5-bromo-3H-imidazo [4,5-b] pyridine is of great significance in organic synthesis, materials science, coordination chemistry and other fields due to its structure and bromine atomic properties. Its chemical properties provide a broad space for the creation of new compounds and the development of functional materials.

5-Bromo-3H-imidazo [4,5-b] pyridine is an important organic compound, and its common synthesis methods include the following:
First, the compound containing the structure of the pyridine ring and the imidazole ring is used as the starting material. First, take a pyridine derivative with a suitable substituent and react with a nitrogen-containing reagent and a brominating reagent under suitable reaction conditions. If pyridine-2,3-diamine and ethyl bromopropionate are used as raw materials, under the action of alkali catalysis, the two are condensed first to form a preliminary product. In this process, the base can promote the nucleophilic substitution reaction, and the amino group of pyridine-2,3-diamine attacks the ester group of ethyl bromopropionate to form a new carbon-nitrogen bond. Subsequently, under acidic conditions, a cyclization reaction occurs in the molecule, and the cyclization rearrangement constructs the imidazole ring structure, and bromine atoms are introduced to obtain 5-bromo-3H-imidazo [4,5-b] pyridine.
Second, the bromination reaction is carried out with pyridine-imidazole compounds as substrates. Select a suitable pyridine imidazole derivative, dissolve it in a suitable organic solvent, such as dichloromethane, chloroform, etc., and then add a brominating agent, such as N-bromosuccinimide (NBS). In the presence of an initiator, such as benzoyl peroxide, heat or light initiates the reaction. NBS generates bromine radicals in the system that attack specific locations of the pyridine imidazole ring, usually where the electron cloud density is higher, thereby introducing bromine atoms at the 5-position to obtain the target product 5-bromo-3H-imidazo [4,5-b] pyridine.
Third, the target molecule is constructed through a multi-step reaction. The pyridine ring-containing fragment is first prepared, and the pyridine ring is converted by a series of functional groups, such as halogenation, amination, etc., so that the pyridine ring has suitable substituents. Then it is reacted with the imidazole-containing ring precursor to gradually splice the molecules. For example, 2-amino-3-halo pyridine is synthesized first, and then reacted with imidazole compounds under specific conditions. After multi-step transformation and modification, 5-bromo-3H-imidazo [4,5-b] pyridine is finally synthesized. Each step requires strict control of the reaction conditions, such as temperature, reaction time, and the proportion of reactants, to ensure the selectivity and yield of the reaction.

5-Bromo-3H-imidazo [4,5-b] pyridine is an important organic compound that has applications in many fields.
In the field of medicinal chemistry, its application is crucial. Because of its unique chemical structure, it has the potential to interact with biological macromolecules, and is often regarded as a lead compound for drug development. Studies have shown that these compounds exhibit certain affinity and selectivity to specific enzymes or receptors, and can be used to develop drugs for the treatment of various diseases. For example, for some tumor-related kinases, 5-bromo-3H-imidazo [4,5-b] pyridine derivatives may inhibit the proliferation and metastasis of tumor cells by inhibiting kinase activity, opening up a new path for the development of anti-cancer drugs.
In the field of materials science, it also has outstanding performance. Because of its specific electronic structure and chemical properties, it can participate in the preparation of functional materials. For example, in the preparation of organic optoelectronic materials, the introduction of this compound structural unit may regulate the photophysical and electrochemical properties of materials, improve the luminous efficiency and charge transport properties of materials, and provide new material options for the development of optoelectronic devices such as organic Light Emitting Diode (OLED) and solar cells.
In the field of organic synthetic chemistry, 5-bromo-3H-imidazo [4,5-b] pyridine is an important synthesis intermediate. Its bromine atom and imidazolopyridine structure can participate in many organic reactions, such as nucleophilic substitution reactions, metal catalytic coupling reactions, etc. With the help of these reactions, chemists can construct more complex organic compounds with diverse structures, expand the scope and methods of organic synthetic chemistry research, and promote the continuous development of organic synthetic chemistry.

The market price of 5-bromo-3H-imidazo [4,5-b] pyridine, that is, 5-bromo-3H-imidazo [4,5-b] pyridine, fluctuates due to a variety of factors. This compound is used in the field of medicinal chemistry and is often involved in drug research and development, especially in the process of innovative drug creation. It is often used as a key intermediate because it can participate in the construction of drug activity structures. Its demand may change with the direction of pharmaceutical research and development.
Looking at the past market, its price fluctuations are due to the difficulty of obtaining raw materials, the simplicity of the synthesis process, and the amount of market demand. If the raw materials are scarce, difficult to find, or the synthesis process is complicated, the requirements for technology and equipment are strict, the cost will increase, and the price will also rise. Furthermore, the demand for pharmaceutical research and development is strong, the supply is in short supply, and the price is also high; on the contrary, the demand is weak, the supply is excessive, and the price will decline.
Due to the ever-changing market dynamics, the supply of raw materials, technological innovation, and policy orientation can all influence the price, so it is difficult to determine the exact market price. For details, you can consult chemical raw material suppliers, chemical trading platforms, or study professional market survey reports to obtain accurate price information in the near future.

5-Bromo-3H-imidazo [4,5-b] pyridine is an organic compound. Its physical properties are unique, let me explain in detail.
This substance is usually in a solid state at room temperature. Looking at its appearance, it is mostly white to light yellow powder or crystalline substance, and this color state is easy to visually distinguish with the naked eye.
When it comes to the melting point, it is about a specific temperature range. This melting point is crucial for the maintenance of its physical form in different environments. The characteristics of the melting point determine its transition state at a specific temperature, which affects many subsequent applications.
In terms of solubility, it has a certain solubility in organic solvents, such as common ethanol and dichloromethane. However, in water, the solubility is relatively limited. This difference in solubility is due to the difference between its molecular structure and the interaction between solvent molecules. The molecular structure of organic solvents is compatible with 5-bromo-3H-imidazo [4,5-b] pyridine molecules, which can be promoted by intermolecular forces. However, the molecular structure of water is not well matched with it, so the solubility is low.
In addition, its density is also an important physical property. The specific density value reflects its mass per unit volume, which is a key consideration in practical operations such as substance measurement and mixing. < Br >
Its stability is acceptable under general conditions, but when exposed to high temperature, strong light or a specific chemical environment, the molecular structure may change, which affects its physical properties. For example, at high temperature, or decomposition reactions occur, resulting in changes in appearance, melting point and other properties. These physical properties are of great significance in many fields such as chemical synthesis and drug development, helping researchers understand their characteristics and make good use of them.