5-Bromo-3-pyridinecarboxaldehyde

5-Bromo-3-pyridyl formaldehyde, which is an organic compound. Its physical properties are as follows:
Viewed at room temperature, it is mostly in the state of crystalline powder, white or slightly yellowish in color. Smell, or have a special weak smell, but due to individual differences in olfaction, perception may be different.
In terms of its melting point, the melting point is about 60-65 ° C. At this temperature, the solid phase will gradually melt into the liquid phase. The boiling point is about 270-280 ° C. At this high temperature, the liquid phase will turn to the gas phase.
Solubility is also an important physical property. In organic solvents, such as methanol, ethanol, and dichloromethane, it exhibits good solubility and can mutually dissolve with it to form a uniform solution. However, in water, its solubility is rather limited, only slightly soluble. This is because although there are polar groups in the molecular structure of the compound, the whole is still dominated by non-polar parts, so the interaction with water is weak.
In addition, its density is about 1.72 g/cm ³, which is heavier than water. This density characteristic is quite practical when it comes to operations such as stratification of mixed liquids. The physical properties of 5-bromo-3-pyridyl-formaldehyde are key factors in many fields, such as organic synthesis and chemical analysis, and have a profound impact on related reactions and experimental operations.

5-Bromo-3-pyridyl formaldehyde is an important compound in organic chemistry. It has many unique chemical properties.
First, the presence of the aldehyde group gives it the reactivity of a typical aldehyde. It can be added to nucleophiles, such as with alcohols under acid catalysis, to form acetals. This reaction is often used in organic synthesis as a carbonyl protection method to prevent the aldehyde group from being affected in subsequent reactions.
Furthermore, aldehyde groups can be oxidized, and mild oxidants can convert them to 5-bromo-3-pyridyl carboxylic acid; strong oxidants may further destroy the pyridine ring structure. At the same time, the aldehyde group can also be reduced to 5-bromo-3-pyridyl methanol under the action of suitable reducing agents.
And bromine atoms also have important activities. Under appropriate conditions, nucleophilic substitution reactions can occur, and bromine atoms can be replaced by other nucleophilic groups, such as hydroxyl groups, amino groups, etc., to achieve diverse modification of compound structures. And under metal catalysis, it can participate in coupling reactions, such as Suzuki coupling reactions with borate esters containing alkenyl groups and aryl groups, to construct more complex organic molecular structures, which are widely used in drug synthesis, materials science and other fields.
In addition, the electron cloud distribution characteristics of the pyridine ring make 5-bromo-3-pyridine formaldehyde can be used as a ligand to complex with metal ions to form metal-organic complexes, showing unique physical and chemical properties, and has potential application value in catalysis, luminescent materials, etc. Its chemical properties are rich and diverse, providing a broad space for research in many fields such as organic synthesis and materials science.

The synthesis methods of 5-bromo-3-pyridyl formaldehyde have been known in ancient times and are of various kinds. The main ones are briefly described as follows.
First, 3-pyridyl formaldehyde is used as the starting material, and the target product can be obtained by bromination reaction. In this process, liquid bromine or N-bromosuccinimide (NBS) is often used as the bromination reagent. If liquid bromine is used, liquid bromine should be slowly added dropwise in a suitable solvent, such as dichloromethane, at low temperature, and an appropriate amount of catalyst, such as iron powder or iron tribromide, should be added to promote the reaction. During the reaction, liquid bromine and 3-pyridine formaldehyde undergo electrophilic substitution reaction, and bromine atoms selectively replace hydrogen atoms at specific positions on the pyridine ring to generate 5-bromo-3-pyridine formaldehyde.
Second, 5-bromo-3-methylpyridine is used as raw material and prepared by oxidation reaction. Commonly used oxidants include potassium permanganate, potassium dichromate, etc. In a suitable reaction system, such as in an alkaline solution, potassium permanganate can oxidize the methyl of 5-bromo-3-methylpyridine to an aldehyde group. This reaction requires controlling the reaction temperature and the amount of oxidant to avoid excessive oxidation and affect the purity and yield of the product.
Third, through the metal-catalyzed cross-coupling reaction of pyridine derivatives, and then synthesized by functional group conversion. First, metal catalysts, such as palladium catalysts, are used to cross-couple pyridine derivatives containing specific functional groups with compounds containing bromine and aldehyde precursors to construct the target molecular skeleton, and then through appropriate functional group conversion reactions, 5-bromo-3-pyridine formaldehyde is generated. This method requires harsh reaction conditions, and factors such as reaction temperature, catalyst dosage, and ligand types need to be precisely controlled to ensure the high efficiency and selectivity of the reaction.
The above synthesis methods have their own advantages and disadvantages. In practical applications, appropriate methods should be carefully selected based on factors such as raw material availability, reaction conditions, cost, and product purity requirements.

5-Bromo-3-pyridyl formaldehyde is useful in various fields such as medicinal chemistry and materials science.
In medicinal chemistry, it is a key intermediate for the synthesis of various drugs. Due to its unique structure of pyridine ring and aldehyde group, it can participate in various chemical reactions, such as condensation reaction with nucleophiles such as nitrogen and oxygen, to construct bioactive heterocyclic compounds. By modifying its bromine atom, specific functional groups can be introduced to modulate the activity, selectivity and pharmacokinetic properties of drug molecules. For example, in the development of anti-tumor drugs, using 5-bromo-3-pyridyl formaldehyde as the starting material, through multi-step reaction, compounds that can precisely act on specific targets of tumor cells can be prepared, which can contribute to the solution of cancer problems.
In the field of materials science, it has also made a name for itself. It can be used as a basic unit for the construction of new organic optoelectronic materials. Pyridine rings and bromine atoms give molecules good electron transport properties and modifiability, while aldehyde groups provide active check points for intermolecular polymerization or cross-linking. The materials synthesized from this have great potential in the fields of Light Organic Emitting Diode (OLED) and organic solar cells. For example, for OLED, it can improve the luminous efficiency and stability, so that the color gamut of the display device is wider and the image quality is better; for organic solar cells, it can improve the photoelectric conversion efficiency and promote the development of renewable energy.
In addition, in organic synthetic chemistry, 5-bromo-3-pyridyl formaldehyde is often an important building block for the construction of complex organic molecules. Because of its rich reaction check points, chemists can ingeniously design reaction paths according to different needs, realize the precise synthesis of various complex structures, and inject vitality into the development of organic synthetic chemistry.

5-Bromo-3-pyridyl formaldehyde, the price of this substance in the market is difficult to determine. The change in its price is related to various reasons.
First, the cost of production is the basis of the price. The purchase of raw materials is well selected, and the price is not cheap. Its extraction and purification techniques require exquisite tools and methods, which all increase its cost. If the raw materials are rare, the process is difficult, the cost will be high, and the price will rise accordingly.
Second, the situation of demand and supply determines the price. If there are many people in the market who need it, the demand is greater than the supply, and the merchants will raise the price in pursuit of profit; on the contrary, if the supply exceeds the demand, the price may be reduced to promote sales. In case of a new industry, the demand for it will surge, and the price will often rise; if the old use is gradually decreasing, but the supply has not decreased, the price will tend to fall.
Furthermore, changes in the current situation also involve price fluctuations. Political regulation, tax increases and decreases, all have an impact. If tariffs increase, the price of entering the market will be higher; if regulations are strict, the cost of production will increase, and the price will also rise. Or in case of natural and man-made disasters, the place of origin will be damaged, and the production and supply will be insufficient, and the price will jump.
There are also quality points, which will lead to different prices. Those with high purity and few impurities will have high prices; those with inferior quality will have low prices. In high-precision fields such as medicine and electronics, high-purity products are required, and the price is often high; if it is for general industrial use, the purity requirements are slightly lower, and the price is also slightly inferior.
To sum up, in order to know the exact price of 5-bromo-3-pyridyl formaldehyde, it is necessary to carefully examine various factors in the market, and its price is not constant, and it changes from time to time, making it difficult to have a definite number for you.