5-bromo-3-iodopyridine

5-Bromo-3-iodopyridine is also an organic compound. Its main uses are quite extensive, and it plays a significant role in the field of organic synthesis.
First, it can be used as a pharmaceutical intermediate. In the process of drug development, many drug molecules need to be constructed from this as the starting material. The structural characteristics of the Geynepyridine ring endow the compound with unique reactivity and spatial structure. It can be linked to other organic fragments through various chemical reactions, such as nucleophilic substitution, coupling reactions, etc., to construct drug molecular structures with specific biological activities. For example, in the synthesis of some antibacterial drugs and anti-tumor drugs, 5-bromo-3-iodopyridine can act as a key intermediate, laying the foundation for the synthesis of drugs with precise pharmacological effects.
Second, it also has important uses in materials science. In the preparation of organic optoelectronic materials, specific functional groups can be introduced through chemical modification with the help of the activity of bromine and iodine atoms to regulate the photoelectric properties of the materials. By combining with the conjugated system, organic materials with good fluorescence properties or semiconductor properties can be prepared, which can be used in organic Light Emitting Diode (OLED), organic solar cells and other devices to improve their luminous efficiency, carrier transport performance and other key indicators.
Third, it is also indispensable in the field of pesticide synthesis. It can be used as an important raw material for the synthesis of new pesticides, and its structural characteristics can be used to design and synthesize pesticides with high-efficiency control effects on specific pests and diseases. With the stability of the pyridine ring and the special activity given to the product after the participation of bromine and iodine atoms in the reaction, the synthesized pesticides play an important role in crop protection, and help to develop environmentally friendly, efficient and low-toxicity new pesticide varieties.

The synthesis method of 5-bromo-3-iodopyridine is not directly described in the ancient book Tiangong Kaiwu, but various routes can be obtained by chemical methods.
First, pyridine is used as the starting material, and bromine atoms are first introduced through bromination reaction. In a suitable solvent, such as dichloromethane, in the presence of a catalyst such as iron powder or iron tribromide, pyridine undergoes an electrophilic substitution reaction with bromine. Due to the electron cloud distribution characteristics of the pyridine ring, the bromine atom preferentially enters the 3-position to obtain 3-bromopyridine. Subsequently, 3-bromopyridine is further reacted with the iodine source to introduce the iodine atom. Under basic conditions, such as the presence of potassium carbonate, it can react with iodine in a suitable solvent such as N, N-dimethylformamide (DMF), and introduce 5-position iodine atom through halogen atom switching, so as to obtain 5-bromo-3-iodopyridine.
Second, 3-aminopyridine can also be started from 3-aminopyridine. First protect the amino group, such as tert-butoxycarbonyl (Boc) to protect the amino group to obtain N- (tert-butoxycarbonyl) -3-aminopyridine. After that, the bromine atom can be introduced at the 5-position by reacting with the brominating reagent, and then the amino group can be deprotected, and then the amino group can be converted into an iodine atom through the Sandmeier reaction. The specific operation is to first diazotize the amino group, and then react with potassium iodide. After a series of reactions, 5-bromo-3-iodopyridine can finally be obtained.
Third, metal-catalyzed coupling reaction can also be used. For example, using 3-bromopyridine as a substrate, under the action of palladium catalyst, such as tetra (triphenylphosphine) palladium, in a basic environment and the presence of suitable ligands, a coupling reaction occurs, and iodine atoms are introduced at the 5-position to achieve the synthesis of 5-bromopyridine.

5-Bromo-3-iodopyridine is one of the organic compounds. Its physical properties are generally as follows.
Looking at its morphology, under normal temperature and pressure, it is mostly in a solid state, but the specific shape, either crystalline or powder, depends on the subtle difference between the preparation method and the environment.
In terms of its melting point, it is about a specific temperature range. This temperature is not a constant value, but varies slightly due to factors such as the purity of the sample. If the purity is very high, the melting point range is relatively narrow and tends to be fixed; if it contains impurities, the melting point may decrease and the melting range becomes wider.
As for the boiling point, under certain pressure conditions, there is also a corresponding value. However, when measuring the boiling point, accurate control of pressure is crucial, and small pressure changes can cause boiling point values to vary.
In terms of solubility, in organic solvents, such as dichloromethane, chloroform, tetrahydrofuran, etc., often show a certain degree of solubility. This solubility depends on the interaction of molecular forces. The bromine and iodine atoms contained in its molecular structure, as well as the characteristics of the pyridine ring, enable it to form a specific interaction with organic solvent molecules, which makes it soluble. However, in water, due to the poor matching of its polarity with that of water, its solubility is relatively poor. < Br >
In color, pure 5-bromo-3-iodopyridine, or colorless to light yellow appearance. If the color is different, it may imply that it contains impurities, and the type and content of impurities will also affect the color depth and hue.
In terms of smell, it usually has a weak smell of organic compounds, but its taste is not strong, unlike some volatile and pungent organic compounds. The generation of this weak smell is also related to the volatility and structure of the molecule. The volatility of the molecule is relatively limited, so the smell is not very significant.

5-Bromo-3-iodopyridine is one of the organic compounds. Its chemical properties are unique and interesting.
Bear the brunt. This compound contains two halogen atoms, bromine and iodine, with high halogen atom activity and easy to induce chemical reactions. In the nucleophilic substitution reaction, the halogen atom can be replaced by other nucleophilic reagents. For example, when encountering strong nucleophilic reagents such as alkoxides and amines, the halogen atom may be replaced to form a new nitrogen-containing or oxygen-containing derivative. This property is of great significance in organic synthesis, and it can be used to construct multiple and complex organic molecular structures.
Furthermore, the pyridine ring is aromatic, which makes the molecule relatively stable. However, the presence of bromine and iodine on the ring will affect the electron cloud distribution of the ring and change the reactivity of the pyridine ring. Generally speaking, the halogen atom is an electron-withdrawing group, which will reduce the electron cloud density of the pyridine ring, reduce the activity of electrophilic substitution, and increase the activity of nucleophilic substitution.
In the reduction reaction, the halogen atom of 5-bromo-3-iodine pyridine may be reduced and removed. For example, under the action of a specific reducing agent, bromine and iodine atoms may be converted into corresponding hydrogen atoms to form pyridine derivatives.
In addition, its chemical properties are also affected by reaction conditions, such as temperature, solvent, catalyst, etc. Different reaction conditions may cause different reaction rates and product selectivity. For example, high temperature or accelerate the reaction process, and specific solvents may affect the reaction selectivity.
In summary, 5-bromo-3-iodopyridine exhibits rich chemical properties due to the interaction of halogen atoms and pyridine rings, and has broad application prospects in the field of organic synthesis.

5-Bromo-3-iodopyridine is also an organic compound. In the market price range, it is difficult to determine its fixed number. The price often varies due to a variety of factors, such as the price of raw materials, the method of preparation, the situation of supply and demand, the competition in the market, and even the region and season.
In the past, the price of raw materials was stable, the preparation method was excellent, and the supply exceeded the demand, so the price was slightly lower; if the raw materials were scarce, the production method was complicated, and the supply was in short supply, the price would be high. In addition, different regions have different prices due to differences in transportation costs and market demand. In prosperous cities, the demand is strong and the transportation is convenient, and the price may be moderate; in remote places, the transportation is difficult and the demand is small, and the price may be higher. < Br >
However, based on past examples, if the quality is ordinary and the quantity is also ordinary, the price per gram may be between tens and hundreds of yuan. If it is of high purity and used in special fields, such as high-end pharmaceutical research and development, the price may be higher, or thousands of yuan per gram. In short, to know the exact price, you need to carefully observe the current market conditions and consult the supplier.