5-Bromo-3-hydroxypyridine

5-Bromo-3-hydroxypyridine is also an organic compound. It has a wide range of uses and is often a key intermediary in the field of medicinal chemistry. Due to its special molecular structure, many bioactive compounds can be derived by chemical synthesis. For example, when creating antibacterial drugs, 5-bromo-3-hydroxypyridine can provide a unique structural unit for synthesis, helping to build molecules that have inhibitory or killing effects on specific pathogens.
In the field of materials science, it also has its uses. Or can participate in the preparation of functional polymer materials, giving materials special properties such as light and electricity. For example, by polymerizing it with other monomers through a specific reaction, the resulting polymer may have a unique optical response, which can be applied to optical sensing and other aspects.
Furthermore, in organic synthetic chemistry, it is an important building block. Chemists can build more complex organic molecules through a series of reactions such as halogenation and hydroxyl substitution based on its structure, expanding the types and functions of organic compounds, and opening up new avenues for scientific research and industrial production. From this perspective, although 5-bromo-3-hydroxypyridine is small, it plays a significant role in many fields and is an important cornerstone of organic chemistry.

There are several common methods for synthesizing 5-bromo-3-hydroxypyridine.
First, 3-hydroxypyridine is used as the starting material. This compound can be used with brominating reagents, such as liquid bromine or N-bromosuccinimide (NBS), etc., under suitable reaction conditions. If liquid bromine is used, it is often required in organic solvents, such as dichloromethane, at low temperatures and in the presence of catalysts such as iron powder or iron tribromide. The catalyst can promote the polarization of bromine molecules and is more prone to electrophilic substitution with 3-hydroxypyridine. Due to the fact that the hydroxyl group is an ortho-para-site and the electron cloud density of the pyridine ring is relatively low, the reaction mainly occurs at the hydroxy-para-site, that is, the 5-position, resulting in 5-bromo-3-hydroxypyridine.
Second, 3-aminopyridine is started from 3-aminopyridine. First, the diazotide is reacted with sodium nitrite and hydrochloric acid at low temperature to obtain the diazotide salt. Subsequently, the diazotide salt is reacted with the hydrobromic acid solution of cuprous bromide (CuBr), which is known as the Sandmeyer reaction. The diazo group is replaced by the bromine atom to form a precursor of 5-bromo-3-hydroxypyridine, and then the amino group is converted into a hydroxyl group through appropriate hydrolysis and other steps, and the final target product is obtained.
Third, using pyridine as the starting material, pyridine is brominated first, and bromine atoms are introduced. Suitable brominating agents and reaction conditions can be selected to make bromine atoms preferentially substituted at the 3rd position. After that, 3-bromo pyridine is hydroxylated. This hydroxylation process can be achieved by nucleophilic substitution reaction, such as reacting with strong bases and suitable nucleophilic reagents under specific conditions, so that bromine atoms are replaced by hydroxyl groups to obtain 5-bromo-3-hydroxypyridine.
Synthetic methods have their own advantages and disadvantages. In practical application, it is necessary to comprehensively consider factors such as the availability of raw materials, the difficulty of reaction conditions, yield and purity requirements, and choose the best.

5-Bromo-3-hydroxypyridine is one of the organic compounds. It has unique physical properties and is very important in the field of chemistry.
Looking at its morphology, at room temperature, 5-bromo-3-hydroxypyridine is mostly in a solid state. Its color is often white to light yellow, and its appearance is delicate, resembling powder but not powder, with a specific crystal structure. This structure gives it a relatively stable physical state, making it possible to store for a long time under conventional conditions without significant changes.
When it comes to melting point, the melting point of 5-bromo-3-hydroxypyridine is within a certain range. The characteristics of this melting point are crucial for its purification, identification and application in chemical reactions. Knowing its melting point, chemists can determine the purity of the substance by means of melting point determination. If the measured melting point is consistent with the theoretical value, it indicates that the purity of the substance is high; if there is a deviation, further purification is required.
In terms of solubility, 5-bromo-3-hydroxypyridine behaves differently in different solvents. It has certain solubility in polar solvents such as methanol and ethanol. This is because the molecular structure of the compound contains hydroxyl groups, which are polar groups and can form hydrogen bonds with polar solvents, so it is soluble. However, in non-polar solvents such as n-hexane and benzene, its solubility is poor. This difference in solubility is an important consideration in many chemical operations such as separation, extraction, and choice of reaction medium.
Furthermore, the density of 5-bromo-3-hydroxypyridine is also one of its physical properties. Its density is specific, although it is not the focus of daily attention, it is indispensable in accurate stoichiometry and reaction system design. Accurately knowing its density can help chemists accurately configure the solution and control the proportion of reaction materials, thus ensuring the smooth progress of chemical reactions and the accuracy of results.
In addition, 5-bromo-3-hydroxypyridine has a certain stability when it is in solid state. When exposed to high temperature, strong light or specific chemical substances, its stability may be affected. Under high temperature, decomposition reactions may occur, resulting in molecular structure rupture; strong light irradiation may also lead to luminescent chemical reactions and change its chemical composition.
In summary, the physical properties of 5-bromo-3-hydroxypyridine, such as morphology, melting point, solubility, density and stability, are interrelated and play a crucial role in many chemical-related fields such as organic synthesis and drug development, providing a basic basis for chemists to carry out various research and applications.

5-Bromo-3-hydroxypyridine, the market price of this substance, often varies for various reasons. The fluctuation of its price is related to many factors, the first being the price of raw materials. If the raw material for the preparation of 5-bromo-3-hydroxypyridine, its price rises, the price of 5-bromo-3-hydroxypyridine also rises; conversely, the price of raw materials decreases, and its price also decreases.
Furthermore, the difficulty of the process also affects its price. If the preparation method is complicated, high-end equipment and exquisite skills are required, and a lot of manpower and material resources are invested, the price will be high; if the process is simple, the cost will be reduced, and the price will be correspondingly lower.
The supply and demand situation in the market is even more critical. If there are many applicants, but there are few producers, and the supply is in a state of shortage, the price will rise; if there is an oversupply, the merchant will sell their goods, and the price will easily drop.
In addition, the current situation also has an impact. In case of trade disputes, policy changes, or transportation blockages, the price can fluctuate.
Looking at the past market, the price of 5-bromo-3-hydroxypyridine is between hundreds and thousands of yuan per kilogram. However, this is only a rough estimate. The actual price should be determined according to the real-time market conditions, differences in quality, and the volume of transactions. To know the exact price, it is advisable to consult the chemical raw material supplier, or check the market of the chemical product trading platform in detail to obtain the exact number.

5-Bromo-3-hydroxypyridine, when storing and transporting, pay attention to many matters. This substance has specific chemical properties, so when it is stored, the first priority is the drying of the environment. If it encounters water vapor, or reactions such as hydrolysis, it will damage its purity and quality. It must be placed in a dry and airtight container, away from moisture.
As for the temperature, it should be stored in a cool place, not near heat sources and open flames. It may be heated, or cause changes in chemical structure, or even dangerous reactions. Generally speaking, room temperature or slightly lower temperature is appropriate, but the specific temperature range should be determined according to its physical and chemical properties.
When transporting, the packaging must be solid and reliable. In order to prevent the package from being damaged and leaking due to vibration and collision. Choose suitable packaging materials, such as corrosion-resistant containers, and seal them tightly. During transportation, it is also necessary to avoid mixing with other substances, especially those that can chemically react with them, such as strong oxidants, strong acids and alkalis. If mixed, it may cause violent reactions and endanger transportation safety.
Furthermore, the place of transportation and storage should be clearly marked, indicating its chemical name, characteristics and dangerous precautions, so that relevant personnel can see at a glance and operate according to specifications, so as to ensure that 5-bromo-3-hydroxypyridine is safe during storage and transportation.