5-Bromo-3-fluoro-2-hydroxypyridine

5-Bromo-3-fluoro-2-hydroxypyridine is one of the organic compounds. It has unique chemical properties and is very important in the field of organic synthesis.
Looking at its structure, the substitution of bromine, fluorine and hydroxyl groups on the pyridine ring endows it with specific activities. Hydroxyl groups can participate in the formation of hydrogen bonds, play a key role in intermolecular interactions, or affect its solubility and crystal structure. Bromine atoms are relatively large, and the electronic effect is significant. Through induction and conjugation effects, it can affect the distribution of electron clouds in the pyridine ring, change the electron cloud density on the ring, and then affect the electrophilic substitution and nucleophilic substitution reactivity. The fluorine atom has strong electronegativity, which will strengthen the molecular polarity after introduction, and also affect the reaction activity and chemical stability.
In chemical reactions, the bromine atom of 5-bromo-3-fluoro-2-hydroxypyridine can be used as a leaving group to participate in nucleophilic substitution reactions, and react with many nucleophilic reagents such as alcohols and amines to generate corresponding substitutions. Hydroxyl groups can be converted into other functional groups through esterification, etherification and other reactions to expand their chemical derivativeness. In addition, due to the electronic properties of pyridine rings, the compound can be used as a ligand to coordinate with metal ions to form metal complexes, which have potential applications in catalysis, materials science and other fields.
In terms of solubility, due to the existence of polar hydroxyl groups, it may have a certain solubility in polar solvents such as alcohol and water, but bromine and fluorine atoms will limit its solubility in water. Physical properties such as melting point and boiling point are affected by intermolecular forces, and hydrogen bonds and van der Waals forces jointly determine its state transition temperature.
In summary, the chemical properties of 5-bromo-3-fluoro-2-hydroxypyridine are determined by its structure, and its various reactivity and physical properties make it valuable in organic synthesis, medicinal chemistry, materials science and other fields. It is an indispensable chemical raw material in scientific research and industrial production.

5-Bromo-3-fluoro-2-hydroxypyridine is a crucial compound in the field of organic synthesis. It has a wide range of uses and has key applications in many fields such as medicinal chemistry and materials science.
In the field of medicinal chemistry, 5-bromo-3-fluoro-2-hydroxypyridine is often used as a key intermediate. Due to its unique chemical structure, it can undergo a series of chemical reactions to construct complex molecules with specific biological activities. For example, using this as a starting material, through appropriate functional group transformation and cyclization reactions, many heterocyclic compounds with potential pharmacological activities can be synthesized, or used to develop antibacterial, anti-inflammatory, anti-tumor and other drugs. In the process of many drug development, the structural properties of this compound provide the basis for the design of novel and efficient drug molecules, helping chemists to construct pharmacophore that precisely binds to biological targets.
In the field of materials science, 5-bromo-3-fluoro-2-hydroxypyridine is also of great interest. Because it contains specific halogen atoms and hydroxyl groups, it can participate in the polymerization reaction or modification process of materials. By introducing this compound, the material can be endowed with unique optical, electrical or thermal properties. For example, in the preparation of organic optoelectronic materials, it can be integrated into the polymer chain as a structural unit to adjust the energy band structure and charge transport properties of the material, which is expected to improve the performance of organic Light Emitting Diodes (OLEDs) or organic solar cells.
In addition, in the methodological study of organic synthetic chemistry, 5-bromo-3-fluoro-2-hydroxypyridine is often used as a model substrate to explore new chemical reactions and synthesis strategies due to its multiple reactivity checking points. Chemists can use this to study the reaction selectivity and mechanism under different reaction conditions, and promote the development of organic synthetic chemistry. Overall, 5-bromo-3-fluoro-2-hydroxypyridine plays an indispensable role in many scientific fields, and its application prospects are broad, continuously promoting innovation and progress in related fields.

There are several methods for the synthesis of 5-bromo-3-fluoro-2-hydroxypyridine as follows.
First, the compound containing the pyridine ring can be obtained by halogenation and hydroxylation. First, take a suitable pyridine derivative, use a specific halogenating agent, such as a brominating agent and a fluorinating agent, and under suitable reaction conditions, such as in a specific organic solvent, control the reaction temperature and time to introduce bromine and fluorine atoms into the pyridine ring at a specific position. Then, through the hydroxylation step, use a suitable hydroxylating agent, and in a suitable reaction system, form a hydroxyl group at another position, and then obtain the target product 5-bromo-3-fluoro-2-hydroxypyridine.
Second, using benzene series compounds containing bromine, fluorine and other suitable substituents as starting materials, the pyridine ring is constructed by cyclization reaction. In the presence of a specific catalyst, the reaction conditions, such as temperature, pressure and reaction time, are adjusted to rearrange and cyclize the benzene series compounds to form a pyridine structure, while retaining bromine and fluorine atoms. After subsequent modifications, the pyridine ring is hydroxylated at a specific position to synthesize 5-bromo-3-fluoro-2-hydroxypyridine.
Third, the strategy of gradually constructing substituents is adopted. First synthesize a pyridine compound containing some substituents, such as a pyridine derivative containing only one of bromine or fluorine substituents. After that, use various reactions in organic synthesis, such as nucleophilic substitution, electrophilic substitution and other reaction types, introduce other substituents in turn, and finally introduce hydroxyl groups at specific positions through appropriate steps to achieve the synthesis of 5-bromo-3-fluoro-2-hydroxypyridine. Each synthesis method needs to be based on factors such as the availability of raw materials, the difficulty of controlling the reaction conditions, and the purity and yield requirements of the target product to choose the optimal path.

The price range of 5-bromo-3-fluoro-2-hydroxypyridine in the market is difficult to determine. The price of this substance often varies due to various reasons.
First, the amount of production has a great impact on the price. If the preparation method is refined and the yield increases greatly, the price may decrease. On the contrary, if the yield is small, there will be many applicants, and the price will rise.
Second, the quality is high or low, and it is also related to the price. The quality is high, and the price is low.
Third, the supply and demand of the market is the key to the price. If there are too many people using this product, the demand will exceed the supply, and the price will rise; if the supply exceeds the demand, the price will fall.
In addition, the amount of the buyer's purchase can also make the price different. If you buy a large amount, the price may be given; if you buy a small amount, the price may be as usual.
According to past examples, the price of this category of goods may range from a few yuan to a few tens of yuan per gram. However, today is different from the past, and the market conditions are ever-changing, so it is difficult to determine the details. To know the true price, you need to ask pharmaceutical companies, chemical merchants, or check carefully on the platform of chemical materials trading before you can get a near-real price.

5-Bromo-3-fluoro-2-hydroxypyridine is an organic compound, and its storage conditions are very critical. This compound should be placed in a cool, dry and well-ventilated place, away from fire and heat sources. Heat can easily cause it to decompose or cause other chemical reactions, endangering the stability and purity of the substance.
It should be stored in a sealed container to prevent contact with air and moisture. Oxygen and moisture in the air can react with the compound. For example, moisture may promote hydrolysis reactions and affect its quality. In a sealed container, it can effectively isolate external adverse factors.
Since 5-bromo-3-fluoro-2-hydroxypyridine is sensitive to light, light should be avoided. Light can initiate photochemical reactions and change its chemical structure and properties. When storing, choose a dark container such as a brown bottle, or store it in a dark environment.
If conditions permit, it can be stored in an inert gas environment, such as nitrogen atmosphere. The chemical properties of inert gases are stable, which can reduce the chance of compounds reacting with active substances and further ensure their stability.
In addition, the storage area should be kept away from incompatible substances, such as strong oxidants, strong acids, strong bases, etc. In contact with these substances, they are prone to violent chemical reactions, which not only damage 5-bromo-3-fluoro-2-hydroxypyridine, but also pose a safety hazard. In short, follow proper storage conditions to ensure the quality and stability of this compound for subsequent experiments or production needs.