5-Bromo-3-Cyano-2-Hydroxypyridine

5-Bromo-3-cyano-2-hydroxypyridine has a wide range of uses in the field of organic synthesis.
First, it can be used as a key intermediate in pharmaceutical synthesis. When creating specific antimalarial drugs, it can access specific chemical groups through chemical reactions to shape the molecular structure with precise pharmacological activity to achieve the purpose of effectively fighting malaria parasites. Or in the process of developing anti-cancer drugs, 5-bromo-3-cyano-2-hydroxypyridine is transformed through multi-step reactions to construct compounds that combine with specific targets of cancer cells, thereby inhibiting the proliferation of cancer cells.
Second, in the field of pesticide synthesis, it also plays an important role. It can be chemically modified to prepare high-efficiency insecticides. After its chemical structure is ingeniously modified, it can interfere with the nervous system or physiological metabolic pathways of pests, thereby killing pests, and is relatively friendly to the environment. Residue is low.
Third, in the field of materials science, 5-bromo-3-cyano-2-hydroxypyridine can participate in the preparation of special functional materials. For example, in the synthesis of organic materials with photoelectric properties, it is used as a basic structural unit to give the material unique optical and electrical characteristics through rational design and polymerization with other monomers, which is expected to be applied in fields such as organic Light Emitting Diodes (OLEDs) to improve its luminous efficiency and stability.

There are many ways to synthesize 5-bromo-3-cyano-2-hydroxypyridine. First, it can be prepared from compounds containing pyridine rings through a series of reactions such as bromination, cyanidation and hydroxylation.
First take suitable pyridine derivatives and carry out bromination reaction with brominating reagents in suitable reaction systems. The brominating reagents can be selected from liquid bromine, N-bromosuccinimide (NBS), etc. If NBS is used, carbon tetrachloride is often used as the solvent, azobisisobutyronitrile (AIBN) is used as the initiator, and the bromine atom is introduced into the pyridine ring at a specific position by heating and refluxing.
Next, the bromide product is cyanidated. Cyanidation reagents such as sodium cyanide and potassium cyanide can be selected to react in a suitable organic solvent in the presence of a phase transfer catalyst. Phase transfer catalysts such as tetrabutylammonium bromide and organic solvents such as dimethyl sulfoxide (DMSO) promote the replacement of bromine atoms with cyanyl groups.
Finally, the target product is obtained by hydroxylation. 5-Bromo-3-cyano-2-hydroxypyridine can be obtained by introducing hydroxyl groups at corresponding positions in the pyridine ring by basic hydrolysis or other hydroxylation means.
Another synthesis idea is to gradually construct the pyridine ring from simple raw materials, and at the same time introduce the required bromine, cyano and hydroxyl functional groups. For example, small molecules containing carbon, nitrogen, oxygen and other atoms are used as starting materials, and the pyridine ring is formed by cyclization. During the cyclization process or after cyclization, bromine, cyano and hydroxyl groups are introduced in sequence by suitable reactions.
During the synthesis, the appropriate synthesis route should be carefully selected according to the availability of raw materials, the difficulty of reaction conditions, and the high and low yield, so as to achieve the purpose of efficient synthesis of 5-bromo-3-cyano-2-hydroxypyridine.

5-Bromo-3-cyano-2-hydroxypyridine, this is an organic compound. Its physical properties are quite characteristic and it is of great significance to the field of organic synthesis.
When it comes to appearance, 5-bromo-3-cyano-2-hydroxypyridine usually presents a solid form. Specifically, it is a white to light yellow powder with a fine and uniform texture, and it can be seen that its purity is high, and there are no obvious impurities mixed in it. This appearance characteristic provides a certain intuitive basis for its experimental operation and identification.
Its melting point has been determined by many experiments and documented in a specific temperature range. The importance of the melting point is crucial in the identification and purity judgment of compounds. If the melting point deviates from the established range, or implies that the purity of the compound is not good, there are impurities that interfere with the intermolecular forces, resulting in changes in the melting point. By accurately measuring the melting point, the quality of the product can be effectively controlled to ensure that it meets the experimental and production requirements.
Solubility is also an important physical property. 5-Bromo-3-cyano-2-hydroxypyridine has different solubility in common organic solvents. In polar organic solvents such as dimethyl sulfoxide (DMSO), N, N-dimethylformamide (DMF), it exhibits good solubility and can quickly dissolve to form a uniform solution. This property is extremely advantageous in organic synthesis reactions, because it can fully contact the reactants, speed up the reaction process, and improve the reaction efficiency. In non-polar organic solvents such as n-hexane and toluene, the solubility is poor, with only a small amount of dissolution or almost insoluble. This difference is due to the ratio and distribution of polar and non-polar groups in the molecular structure, which determines the strength of the interaction with different solvent molecules.
In addition, the stability of this compound is also a key point of concern. Under normal temperature and pressure, protected from light and dry environment, 5-bromo-3-cyano-2-hydroxypyridine can maintain a relatively stable state, and the molecular structure is not easy to change. However, in case of extreme conditions such as high temperature, strong acid, strong base, etc., its cyano, hydroxyl, bromine atoms and other functional groups may undergo chemical reactions, resulting in changes in molecular structure and loss of original chemical properties. Therefore, when storing and using, pay attention to environmental conditions to avoid deterioration.

5-Bromo-3-cyano-2-hydroxypyridine, the price of this substance in the market is difficult to determine. Its price often varies due to various factors, such as the origin of the product, the quality of the quality, the amount of demand, and even the ups and downs of the market.
Looking at the past, the price of chemical substances often depends on the balance of supply and demand. If there are many producers, but there are few applicants, the price may decline; conversely, if there are many applicants, and the output is insufficient, the price may rise.
In the world of "Tiangong Kaiwu", although there is no such specific chemical, when it comes to all kinds of products, it is said that the difficulty of manufacturing, the thickness of materials and the relationship between price. By extension, if the preparation of 5-bromo-3-cyano-2-hydroxypyridine is difficult and the required materials are rare, the price will be high; if the preparation method is simple and the materials are easy to obtain, the price may be relatively easy.
Looking at the dynamics of the market and emerging fields, such as pharmaceutical research and development and material creation, if the demand for this material increases greatly, its price may also be driven by it. Therefore, if you want to know its exact price, you should carefully examine the current market conditions, consult the merchants and brokers in the industry, or you can get its near-real price. However, the change of price is instantaneous, and what you know today may not be able to meet the needs of tomorrow.

For 5-bromo-3-cyano-2-hydroxypyridine, many matters must be paid attention to during storage and transportation.
Its properties or active state, when stored, the first environment is dry. If it is in a humid place, water vapor is easy to interact with it, causing it to deteriorate and damage its quality. And it should be placed in a cool place to avoid high temperature hot topics. This compound is heated, or decompose, polymerize and other reactions, resulting in changes in its properties.
And it needs to be prevented from mixing with other substances. Because it contains functional groups such as bromine, cyano, and hydroxy groups, it has unique chemical properties and is easy to react with strong oxidants, strong acids, and strong bases. If it is co-stored with a strong oxidizing agent, or a violent oxidation reaction occurs, even if it causes ignition and explosion, it is dangerous.
When transporting, the packaging must be sturdy. Choose suitable packaging materials to ensure that it is not damaged during the bumps and there is no risk of leakage. If it is a liquid, the seal should be especially strict to prevent leakage and outflow, pollution of other things and harm to the environment.
In addition, transporters must understand their characteristics and know emergency methods. In case of leakage, they can quickly take appropriate measures, such as evacuating people, isolating fire sources, cleaning up leaks, etc., to avoid greater disasters. Therefore, when storing and transporting 5-bromo-3-cyano-2-hydroxypyridine, every care should be taken to ensure its safety and quality.