5-Bromo-2-Pyridinecarboxylic Acid

5-Bromo-2-pyridinecarboxylic acid, this is an organic compound. Its shape is mostly white to light yellow crystalline powder. In terms of its physical properties, the melting point is quite high, about 218-222 ° C, and it is quite stable at room temperature and pressure.
Looking at its chemical properties, this compound is rich in carboxyl groups and bromine atoms. The carboxyl groups are acidic and can react with alkali substances to form corresponding carboxylic salts. This reaction is like the usual case of acid-base neutralization. The bromine atom is significantly active and can be used as a leaving group in many chemical reactions to participate in nucleophilic substitution reactions. For example, when nucleophiles are present, bromine atoms are easily replaced to form new organic compounds, which is a commonly used strategy in organic synthesis.
5-Bromo-2-pyridinecarboxylic acid is widely used in the field of organic synthesis due to its unique chemical structure. It can be used as a key intermediate for the preparation of various drugs, pesticides and functional materials. In drug synthesis, with its reactive properties, molecular structures with specific biological activities can be constructed, laying the foundation for the development of new drugs. In the field of pesticides, after chemical modification, high-efficiency and low-toxicity pesticide products may be created, which can help the development of agriculture.

5-Bromo-2-pyridinecarboxylic acid, which has a wide range of uses. In the field of medicinal chemistry, it is a key intermediate for the synthesis of many special drugs. The unique structure of the pyridine ring with bromine atoms and carboxyl groups endows it with excellent reactivity and selectivity. It can be chemically converted into compounds with specific biological activities to fight various diseases, such as the preparation of some anticancer drugs and antibacterial agents.
In the field of materials science, 5-bromo-2-pyridinecarboxylic acid is also useful. It can be used as a ligand to complex with metal ions to construct metal-organic framework materials (MOFs) with unique properties. These materials are outstanding in the fields of gas adsorption, separation and catalysis. Due to their regular and adjustable structure, they can be designed and synthesized according to needs to suit different application scenarios.
Furthermore, in the field of organic synthetic chemistry, 5-bromo-2-pyridinecarboxylic acid is often used as a starting material or reaction substrate. With the nucleophilic substitution activity of bromine atoms and the derivatization properties of carboxyl groups, it can participate in many classical organic reactions, such as esterification reactions, amidation reactions, etc., to construct complex organic compounds, and to open up a path for organic synthesis chemists to create new molecules.

The method of preparing 5-bromo-2-pyridinecarboxylic acid has been described in many books in the past. One method is as follows:
First, use 2-pyridinecarboxylic acid as the starting material and dissolve it in an appropriate amount of solvent, such as glacial acetic acid. In this solution, slowly add an appropriate amount of brominating reagent, commonly known as bromine, and in order to make the reaction smooth, a catalyst, such as red phosphorus, is often used. During the reaction, careful temperature control is required, generally maintained at an appropriate temperature range, such as 60-80 ° C. Under this temperature condition, the reaction can be carried out in an orderly manner. During the reaction process, the reaction process can be closely monitored by means of thin-layer chromatography. After the reaction is completed, the reaction liquid is cooled, and then a suitable alkali solution, such as sodium hydroxide solution, is used to neutralize the reaction liquid to a suitable pH value. Then the reaction mixture is separated and purified. The organic phase is extracted with an organic solvent, such as dichloromethane, and then dried with a desiccant such as anhydrous sodium sulfate. After removing the desiccant, the crude product can be further purified by recrystallization. A suitable solvent, such as ethanol-water mixed solvent, can finally obtain pure 5-bromo-2-pyridinecarboxylic acid. < Br >
Another method is to use 2-methylpyridine as the starting material, first act as a brominating agent to make methyl bromide, and then oxidize bromomethyl to carboxyl group through an oxidation step, and 5-bromo-2-pyridinecarboxylic acid can also be obtained. This oxidation step can be selected with a suitable oxidizing agent, such as potassium permanganate, etc. The reaction conditions also need to be finely regulated to obtain satisfactory yield and purity.

5-Bromo-2-pyridinecarboxylic acid is available in the market, and its price range varies according to changes in market conditions. In the past, in the world of "Tiangong Kaiwu", although there was no confirmation of this chemical, it can be roughly known based on the principles of the ancient market.
At present, 5-bromo-2-pyridinecarboxylic acid is mostly used in chemical and pharmaceutical industries. Its price is determined by the abundance of raw materials, the simplicity of the process, and the amount of use. If the raw materials are easily available, the preparation method is simple, and the market demand is not extremely abundant, its price may be relatively cheap. On the contrary, the raw materials are rare, the craftsmanship is complicated, and there are many people who need them, so the price must be high.
Looking at various markets, the purity is different, and the price is also different. For high purity, the price per gram may be more than tens of yuan to hundreds of yuan. For slightly lower purity, the price may be halved. For bulk purchases, due to the increase in quantity, there may be a profit, and the price per gram may be slightly reduced by several yuan.
However, the market of chemical industry is changing, the price of raw materials can be greatly changed due to the fluctuation of raw material prices, the promulgation of new policies, and the advancement of science and technology. Therefore, if you want to know its exact price, you should carefully observe the market conditions and consult the merchants before you can get it.

5-Bromo-2-pyridinecarboxylic acid, also known as 5-bromo-pyridine2-carboxylic acid, has many elements in its Quality Standard.
Purity is a critical item. High purity products are used in many fields to ensure accurate reactions and reliable results. Generally speaking, high-quality 5-bromo-2-pyridinecarboxylic acid needs to be above 98% purity or even higher to reduce the interference of impurities on subsequent reactions or applications. The content of impurities must be strictly controlled, such as related organic impurities, the total amount should be lower than a certain threshold, such as 0.5%, inorganic impurities such as heavy metal ions, etc., the content must also meet strict standards, such as lead, mercury and other heavy metals, the content per kilogram should be very low micrograms to ensure product safety and quality stability.
Appearance is also an important consideration. Under normal circumstances, 5-bromo-2-pyridinecarboxylic acid should appear white to off-white crystalline powder. If the appearance is abnormal or there is obvious foreign matter, it may suggest that the product quality is in doubt. The melting point range of
is also not negligible. Its melting point is about 180-184 ° C. This physical property can assist in judging the purity and authenticity of the product. If the melting point deviates from this range, or the melting range is too wide, it is very likely that the product contains impurities, resulting in a change in the melting point.
In terms of solubility, 5-bromo-2-pyridinecarboxylic acid should have good solubility in specific organic solvents such as dimethyl sulfoxide (DMSO), N, N-dimethylformamide (DMF), and its solubility in water is relatively limited. Through solubility testing, the quality and purity of the product can be preliminarily evaluated.
The water content also needs to be precisely controlled. Excessive water content may affect the stability and reactivity of the product. Generally, the water content is required to be less than 0.5%. < Br >
In quality inspection, high performance liquid chromatography (HPLC) is commonly used to determine purity and impurity content, melting point meter accurately measures melting point, and Karl Fischer method accurately determines water content. Many Quality Standards work together to ensure that 5-bromo-2-picolinecarboxylic acid meets the needs of different application scenarios.