5-bromo-2-(propan-2-yloxy)pyridine

5-L-2- (propoxy) pyridine, which is mostly used in chemical and synthetic fields.
In the chemical field, its important role is to modify. It can be modified by specific reverse, introducing compounds with different functional groups and bioactive compounds. For example, in some anti-tumor drug research, this is the starting material, and the multi-step reaction is used to build the molecular core of the drug. Using its characteristics of pyridine, pyridine group and propoxy group, it can be used to act on specific targets in the tumor cell, or to control the signal pathway, so as to inhibit the proliferation of the tumor cell and its apoptosis.
In the synthetic field, it relies on its own functional group reaction activity, such as acylation and alkylation. In the case of acetylation, the alkyl group can be acetylated to form ester derivatives. This derivative can be used as an intermediate compound in a synthetic process, and can be synthesized in a step to generate more complex and high-value compounds. It is rich in molecular diversity, providing possibilities for the synthesis of new materials and natural materials. In addition, 5-propoxy-pyridine plays an indispensable role in the chemical field, promoting the development of advanced and synthetic technologies.

To prepare 5-hydroxy- 2 - (isopropoxy) pyridine, there are three methods.
One is the halogenated pyridine method. Take halogenated pyridine and warm it with isopropanol and base. The halogen atom of halogenated pyridine is active, and when it encounters the oxygen anion of isopropanol, it can form an ether bond. If 2-chloro-5-hydroxypyridine and potassium isopropoxy are mixed in a suitable solvent, heated and refluxed, the chlorine atom is replaced by isopropoxy to obtain 5-hydroxy- 2 - (isopropoxy) pyridine. The reaction conditions are mild, and the halogen atom activity of halopyridine affects the reaction rate and yield. The one with high activity has a good yield.
The second is the hydroxypyridine method. Start with 5-hydroxypyridine, and prepare its metal salts first, such as 5-hydroxypyridine sodium salt by reacting with sodium hydride. Then react with isopropyl halides, such as isopropyl bromide or isopropyl chloride, in an aprotic solvent. Sodium ions combine with halogen ions, and isopropyl groups connect with hydroxyoxygen to obtain the target product. Among them, the activity of the halogen and the polarity of the solvent have a significant effect. When the polarity is appropriate, the reaction is good.
The third is the pyridone method. Choose a 2-pyridone derivative, and under specific conditions, introduce an isopropoxy group and hydroxylate it. For example, 2-pyridone is treated with a base to generate an enolate, and then reacts with an isopropylation reagent to introduce an isopropoxy group. After oxidation or other methods, the hydroxyl group is formed in an appropriate position to obtain 5-hydroxy- 2 - (isopropoxy) pyridine. This process step is slightly complicated, but the raw material is easy to obtain, and the target product can also be obtained when the conditions of each step are precisely controlled.

5-Hydroxy- 2 - (isopropoxy) pyridine, this substance is in the form of a white to pale yellow crystalline powder, and its melting and boiling point is quite important. Its melting point is about [X] ° C. At this temperature, the substance gradually melts from a solid state to a liquid state, showing the characteristics of a material state transition. The boiling point is around [X] ° C. When this temperature is reached, the liquid is violently vaporized and converted to a gaseous state.
In terms of solubility, it has good solubility in organic solvents such as ethanol and acetone. Due to the molecular structure of organic solvents and the structure of 5-hydroxyl-2- (isopropoxy) pyridine have a certain degree of compatibility, according to the principle of similarity and dissolution, the interaction force between the two molecules prompts the substance to disperse and dissolve in such solvents. However, the solubility in water is not good, because the polarity of water and the molecular polarity of the substance are quite different, and the intermolecular force is difficult to overcome the difference between the two, so it is difficult to dissolve.
In terms of stability, under conventional environmental conditions, if the temperature and humidity are suitable, and there is no special chemical interference, the substance can maintain a relatively stable state. When encountering strong acids and bases, the stability is affected. The strong chemical activity of strong acids and bases will chemically react with 5-hydroxy- 2 - (isopropoxy) pyridine molecules, causing their molecular structure to change and losing their original characteristics.
In addition, 5-hydroxy- 2 - (isopropoxy) pyridine is volatile to a certain extent and will slowly evaporate into the air in an open environment. This property also needs to be paid attention to during storage and use.

5-Hydroxy-2- (isopropoxy) pyridine, this is a rare chemical substance. The determination of its market price is particularly complicated and depends on various factors.
First, the cost of raw materials is the key factor. To prepare 5-hydroxy-2- (isopropoxy) pyridine, the price of raw materials required fluctuates from time to time. If raw materials are scarce or the preparation process is cumbersome, the cost will be high, and the price will also rise.
Second, the preparation process also has a significant impact. Sophisticated and efficient preparation processes can reduce costs; however, if the process is complicated, special equipment, harsh reaction conditions, or multiple purification steps are required, the cost will increase significantly, resulting in higher product prices.
Third, market supply and demand determine the price. If the substance is in high demand in the fields of medicine, chemical industry, etc., but the supply is limited, the price will rise; conversely, if the demand is weak and the supply is abundant, the price may drop.
Fourth, the quality is related to the price. High-purity, high-quality 5-hydroxyl-2- (isopropoxy) pyridine, due to the difficulty of preparation and strict testing requirements, the price is higher than that of ordinary quality.
Therefore, in order to determine the market price of 5-hydroxyl-2- (isopropoxy) pyridine, it is necessary to carefully consider the raw material cost, preparation process, supply and demand situation, and quality specifications. Today, it is difficult to determine the exact market price without knowing the above details. However, it can be inferred that in the category of fine chemical products, the price may be in a dynamic change due to changes in the above factors.

When storing and transporting 5-% ether-2- (isopropoxy) benzene, it is necessary to pay close attention to many key issues.
First and foremost, temperature control is essential. This substance is very sensitive to temperature, and high temperature can easily increase its volatilization or cause chemical reactions. Therefore, the storage place should be selected in a cool place, and the temperature should be maintained within a specific range, and it must not be too high. If it is transported in extremely hot seasons, effective cooling measures, such as the use of refrigeration equipment, should also be taken to ensure the stability of its chemical properties.
Secondly, the influence of humidity should not be underestimated. Humid environments are highly likely to interact with the substance, thereby reducing its purity or causing deterioration. The storage place must be kept dry, desiccant can be placed around the storage container, and rainwater should also be prevented during transportation to ensure the tightness of the package and prevent water vapor from infiltrating.
Furthermore, the stability of the package is the key link. This substance has a certain chemical activity, and the packaging material needs to be adapted to it and must not chemically react with it. At the same time, the package must be sturdy and durable, able to withstand bumps and collisions during transportation to avoid leakage. When storing, it should be placed reasonably to prevent the package from being damaged due to extrusion.
In addition, keeping away from fire sources and oxidants is a top priority. 5-% ether-2- (isopropoxy) benzene is a flammable substance, and contact with fire sources can easily cause fires or even explosions. The oxidizer can also react violently with it, posing a great safety hazard. Whether it is a storage site or a transportation vehicle, a safe distance should be maintained from the fire source and oxidizer, and complete fire protection facilities should be equipped in the storage area and transportation vehicle.
Finally, clear identification is indispensable. On the storage container and transportation vehicle, the name, characteristics, danger warning and other information of the substance should be clearly marked. In this way, the relevant personnel can clearly know the danger when handling and disposal, and then take appropriate protection and response measures to prevent accidents.