5-Bromo-2-phenylpyridine

5-Bromo-2-phenylpyridine is one of the organic compounds. It has specific chemical properties. In terms of structure, the molecule contains bromine atoms, phenyl groups and pyridine rings. This structure endows it with various chemical activities.
Let's talk about its reactivity first. Bromine atoms are its important reaction check points. Because bromine atoms have certain electronegativity, they can change the density of electron clouds in ortho and para-positions, which can easily lead to nucleophilic substitution reactions. In the case of nucleophilic reagents, bromine atoms can be replaced to derive various derivatives. Taking sodium alcohol as an example, under suitable conditions, alkoxy groups can replace bromine atoms to obtain products containing alkoxy groups, which is an important step in organic synthesis and can increase the diversity of molecular functional groups.
Furthermore, the presence of phenyl groups also affects its properties. Phenyl groups are electron-rich, which can participate in electron delocalization and affect the electron distribution of the pyridine ring. This changes the activity of electrophilic substitution at some positions on the pyridine ring. For example, under certain conditions, a Fu-gram reaction can occur, introducing new groups on the phenyl group to expand the molecular structure complexity.
The pyridine ring of 5-bromo-2-phenylpyridine has a lone pair of electrons in its nitrogen atom, making the compound a certain alkaline. Although pyridine is less basic than aliphatic amines, it can form salts with acids in specific acid-base environments. This property may have applications in the fields of separation, purification or drug development.
In addition, the physical properties of the compound are also related to its chemical properties. Because its structure contains aromatic rings and halogen atoms, it has a certain lipid solubility and good solubility in organic solvents. This property is crucial in the selection of reaction media for organic synthesis. In short, 5-bromo-2-phenylpyridine is rich in chemical properties and is an important basic raw material for organic synthesis chemistry. It has potential applications in pharmaceutical chemistry, materials science and other fields.

5-Bromo-2-phenylpyridine is a compound commonly used in organic synthesis. There are several common synthesis methods as follows.
First, pyridine is used as the starting material, and the phenyl group is introduced before the 2-position of the pyridine ring, which can be achieved by palladium-catalyzed cross-coupling reaction. For example, 2-halogenated pyridine and phenylboronic acid are used as substrates, and in the presence of palladium catalyst, base and ligand, through Suzuki coupling reaction, 2-phenylpyridine intermediates are formed. After introducing the bromine atom at the 5-position of the intermediate, the 5-position bromination can be achieved by halogenation reaction, such as in an appropriate solvent, with N-bromosuccinimide (NBS) as the bromine source, under the action of the initiator, to obtain 5-bromo-2-phenylpyridine.
Second, using benzene as the starting material, the intermediate containing the pyridine structure is first prepared. For example, through a multi-step reaction, the phenyl ring is connected to the nitrogen-containing heterocyclic building unit to form a pyridine derivative. After that, using a selective halogenation strategy, bromine atoms are introduced at the 5-position of the pyridine ring, and phenyl is introduced at the 2-position at the same time. This process requires fine regulation of the reaction conditions to ensure the regioselectivity and yield of the reaction.
Third, it can also be synthesized by step-by-step modification of the substituents on the ring based on suitable heterocyclic compounds. First, the heterocyclic ring is functionalized, and the reactive group that can be further reacted is introduced. Then, through a series of substitution and coupling reactions, phenyl and bromine atoms are introduced in turn, and finally 5-bromo-2-phenylpyridine is obtained. Each method has its own advantages and disadvantages. In practical application, it needs to be selected according to factors such as raw material availability, reaction conditions, cost and purity of target products.

5-Bromo-2-phenylpyridine has applications in many fields. In the field of medicinal chemistry, it can be a key intermediate for the synthesis of characteristic drug molecules. Geinpyridine ring and benzene ring are structurally stable and have unique electronic properties, bromine atoms are active, and can undergo various chemical reactions, such as nucleophilic substitution, to construct complex drug structures. In organic synthesis chemistry, it is an important building block for the construction of complex polycyclic compounds. It can be connected with different organoboronic acids or organotin reagents through metal-catalyzed coupling reactions, such as Suzuki coupling, Stille coupling, etc., to expand carbon-carbon bonds and create novel organic materials and functional molecules. In the field of materials science, 5-bromo-2-phenylpyridine can be used to prepare optoelectronic materials. Due to its aromatic ring structure, it can exhibit good fluorescence properties and carrier transport capabilities. It can be used as a light-emitting layer or transport layer material in the development of optoelectronic devices such as organic Light Emitting Diode (OLED) to improve the luminous efficiency and stability of the device. In the field of pesticide chemistry, it also has potential application value. The combination of pyridine and benzene ring may give it a certain biological activity, and bromine atoms can optimize its affinity and effect on specific targets, or can develop new pesticides to control pests and diseases. In conclusion, 5-bromo-2-phenylpyridine has broad application prospects in the fields of medicine, organic synthesis, materials, and pesticides due to its unique structure, and is an important basic substance for the development of many chemical synthesis and functional materials.

5-Bromo-2-phenylpyridine, the market price of this substance is difficult to determine. The price often fluctuates due to changes in market conditions, supply and demand trends, differences in quality, and even differences in production methods and regions.
In the chemical market, if the quality is ordinary and only used for general purposes, the price may be relatively easy. However, if the purity is extremely high, it is suitable for high-end scientific research experiments, such as pharmaceutical research and development, cutting-edge research in materials science, etc., the price will be high.
Looking at the market of the past, when the supply exceeds the demand, the merchants compete to sell, and the price may be low; if the supply exceeds the demand, the demand will compete to buy, and the price may rise. In addition, the distance of the place of origin and the cost of transportation are also variables of the price.
To determine the market price, you should carefully investigate the platform of chemical trading, consult the merchants who specialize in it, or refer to the price of the same industry. In this way, you can obtain a more accurate market price to meet the needs.

5-Bromo-2-phenylpyridine is also an organic compound. It has specific physical properties, which are listed in detail below:
First appearance, under room temperature and pressure, 5-bromo-2-phenylpyridine is white to light yellow solid powder. Looking at it, the color is relatively pure and the texture is uniform. This appearance characteristic is quite critical in the preliminary identification and application.
Second, the melting point is between 78 and 82 ° C. Melting point, the critical temperature at which a substance changes from a solid state to a liquid state. This temperature range indicates that 5-bromo-2-phenylpyridine can be melted into a liquid state at a relatively low temperature, reflecting the characteristics of its intermolecular forces. It has a profound impact on its physical state and processing applications under different temperature environments.
Furthermore, solubility, 5-bromo-2-phenylpyridine is insoluble in water, but it can be soluble in common organic solvents such as dichloromethane, chloroform, toluene, etc. This solubility characteristic is due to the presence of hydrophobic benzene rings, pyridine rings, and bromine atoms in its molecular structure, which makes it more prone to interact with non-polar or weakly polar organic solvents. This property is of great significance for the selection of suitable solvent systems to realize the process of dissolution, reaction or separation in many chemical operations such as organic synthesis, separation and purification.
And its boiling point, although the exact boiling point data may vary due to differences in experimental conditions, it is roughly in the higher temperature range. The boiling point is the temperature point at which a substance changes from a liquid state to a gaseous state. A higher boiling point means that it needs to absorb more energy in the liquid state to gasify, reflecting the strong intermolecular forces of the compound, which also affects its stability and application in high temperature environments.
In addition, the density of 5-bromo-2-phenylpyridine is also one of its important physical properties. Although the exact density value needs to be professionally determined, in general, its density is similar to that of common organic compounds. The characteristics of density are related to its distribution in solution or mixed system and its interaction with other substances. It is an indispensable consideration in practical applications such as the preparation of composites and the preparation of solutions.