5-Bromo-2-phenoxypyridine

5-Bromo-2-phenoxypyridine is also an organic compound. It has a wide range of uses and is often a key intermediate in the synthesis of drugs in the field of medicinal chemistry. Due to its unique structure, it can undergo various chemical reactions to construct complex drug molecular structures to develop new drugs with specific pharmacological activities.
It also has important applications in the field of materials science. It can participate in the preparation of functional materials, such as optoelectronic materials. Due to its specific electronic properties and structure, it can endow materials with unique optical and electrical properties, such as improving the luminous efficiency and charge transport ability of materials, thereby enhancing the application efficiency of materials in optoelectronic devices (such as organic Light Emitting Diodes, etc.).
Furthermore, in the field of pesticide chemistry, 5-bromo-2-phenoxypyridine can also be an important raw material for the synthesis of new pesticides. With appropriate chemical modification, pesticide products with high-efficiency insecticidal, bactericidal or herbicidal activities can be created, providing powerful means for agricultural pest control and weed control.
From this perspective, 5-bromo-2-phenoxypyridine has shown important application value in many fields such as medicine, materials and pesticides due to its unique chemical structure. It is an indispensable key compound in the field of organic synthetic chemistry.

The synthesis method of 5-bromo-2-phenoxy-pyridine has been described in many ancient books. One method is to use 2-hydroxypyridine as the base and first go through bromination to introduce bromine atoms at 5 positions to obtain 5-bromo-2-hydroxypyridine. In this step, suitable brominating agents, such as liquid bromine, N-bromosuccinimide (NBS), etc., should be selected, and carried out under appropriate solvent and reaction conditions, or temperature control or catalyst should be added to promote the smooth reaction. Then, let 5-bromo-2-hydroxypyridine react with phenol in an alkaline environment to form 5-bromo-2-phenoxypyridine. Among the basic reagents, potassium carbonate, sodium hydroxide, etc. can be selected, and the solvent can be dimethylformamide (DMF), N-methylpyrrolidone (NMP), etc., through the mechanism of nucleophilic substitution, the target product can be achieved.
There is another way, starting with 2-chloropyridine, and brominating 5-bromo-2-chloropyridine first. Then the phenol salt of phenol is reacted with 5-bromo-2-chloropyridine, which is also a process of nucleophilic substitution. When preparing phenol salts, phenol can be used with bases such as sodium hydride, potassium tert-butoxide, etc. During the reaction, the properties of the solvent and the degree of temperature need to be considered to achieve a good yield.
Furthermore, or pyridine derivatives can be started, and bromine atoms and phenoxy groups can be gradually introduced through multi-step reactions. For example, the pyridine ring is modified first, and a suitable substituent is introduced to lay the foundation for subsequent bromination and phenoxylation. Each step of the reaction requires attention to the control of reaction conditions, the suppression of side reactions, and fine operation in order to smooth the synthesis and obtain the product of 5-bromo-2-phenoxy pyridine.

The market price of 5-bromo-2-phenoxy-pyridine is difficult to determine for many reasons. The price of this chemical fluctuates greatly under different purity, supply sources and market demand.
In the past, in the market of chemical raw materials trading, if it is 5-bromo-2-phenoxy-pyridine of ordinary industrial purity, the price per kilogram may be around a few hundred yuan. However, if its purity is extremely high, reaching the fine level of laboratories, and is dedicated to high-end uses such as scientific research, its price may rise sharply, and the price per gram may exceed 100 yuan, which can be converted into tens of thousands of yuan per kilogram.
Looking at the price trend of chemical products in the past, the rise and fall of raw material costs, the difficulty of synthesis processes, and the balance of market supply and demand are all the keys to determining their prices. If the price of the basic raw materials required for the preparation of 5-bromo-2-phenoxy pyridine rises, or the synthesis process is complex, requiring a lot of resources and manpower, the cost will increase, and the price will also rise. Furthermore, the market demand for it is strong, and the supply exceeds the demand, the price will also rise; conversely, if the demand is low and the supply is excessive, the price will decline.
Today, if you want to know the exact market price, you can get more accurate price information by consulting chemical raw material suppliers, browsing professional chemical product trading platforms, or referring to recent relevant market survey reports.

5-Bromo-2-phenoxy-pyridine is one of the organic compounds. It has various physical and chemical properties and has attracted much attention in the field of organic synthesis.
In terms of its physical properties, under normal conditions, 5-bromo-2-phenoxy-pyridine is mostly in a solid state, with a color similar to white, but it also varies slightly due to differences in purity and preparation methods. The determination of its melting point is crucial for the identification and purity evaluation of the compound. After many experimental investigations, its melting point roughly falls within a specific temperature range. This range varies slightly due to subtle changes in experimental conditions, but is roughly stable, which is one of the key characteristics for the identification of this compound.
As for solubility, this compound exhibits different behaviors in organic solvents. In common organic solvents, such as dichloromethane, chloroform, etc., its solubility is quite good, and it can dissolve with it to form a uniform solution. This property is of great significance in the process of organic synthesis, such as the selection of reaction solvents, the separation and purification of products. It can participate in various chemical reactions smoothly in suitable solvents and achieve the desired synthesis goals.
When it comes to chemical properties, the bromine atom and phenoxy group in the molecule of 5-bromo-2-phenoxy pyridine are active reaction check points. Bromine atoms can participate in nucleophilic substitution reactions, and many nucleophilic reagents, such as alkoxides and amines, can be substituted with them, thereby introducing various functional groups and expanding the structure and function of compounds. The presence of phenoxy groups also affects the electron cloud distribution of molecules, changing the electron density of pyridine rings, and then affecting their reactivity and selectivity with other reagents.
In addition, in the redox reaction system, 5-bromo-2-phenoxy pyridine can also exhibit specific chemical behaviors. In case of suitable oxidizing agents or reducing agents, the molecular structure will change, or the rise and fall of oxidation states, or the transformation of functional groups will occur, which is a manifestation of its chemical richness. In conclusion, the physicochemical properties of 5-bromo-2-phenoxypyridine provide a broad research and application space for organic synthetic chemists, and have potential important value in the creation of new organic materials and the synthesis of pharmaceutical intermediates.

5-Bromo-2-phenoxypyridine is an organic compound. During storage and transportation, many key matters need to be paid attention to.
Bear the brunt, and the temperature and humidity of the storage environment must be strictly controlled. This compound is mostly sensitive to temperature and humidity. If the temperature is too high, it may decompose and deteriorate, and if the humidity exceeds normal, it may cause moisture degradation. Therefore, a cool and dry place should be selected to maintain the temperature within a specific range, and the humidity should also be maintained within an appropriate range. For example, the temperature should be controlled at 2-8 ° C, and the humidity should not exceed 60%.
Secondly, the storage place must be protected from direct light. Light may trigger photochemical reactions, causing its structure to change and quality to be damaged. It can be stored in shading packaging materials, such as brown glass bottles, shading plastic bags, etc., to ensure that it is protected from light.
Furthermore, 5-bromo-2-phenoxy pyridine may be toxic and corrosive to a certain extent, and it needs to be isolated from other chemicals during storage. Do not mix with oxidants, reducing agents, acids, alkalis, etc., to prevent dangerous chemical reactions. Special areas should be set up for classified storage, and prominent warning signs should be posted.
When transporting, the packaging must be solid and firm. Use suitable packaging materials, such as strong plastic drums, iron drums, etc., and fill with cushioning materials to prevent packaging damage and material leakage due to collision and vibration during transportation.
Transportation personnel also need professional training to be familiar with the characteristics of this compound and emergency treatment methods. During transportation, environmental conditions such as temperature and humidity should be closely monitored to ensure a stable transportation environment. If there is an emergency situation such as leakage on the way, it must be able to quickly and properly handle it according to the emergency plan to avoid greater harm.