5-bromo-2-oxo-1,2-dihydropyridine-3-carbonitrile

5-Bromo-2-oxo-1,2-dihydropyridine-3-carbonitrile, Chinese name or 5-bromo-2-oxo-1,2-dihydropyridine-3-formonitrile. This substance has a wide range of uses and is often used as a key intermediate in the field of medicinal chemistry to assist in the synthesis of a variety of biologically active compounds. For example, when developing specific anti-cancer drugs, their structural properties can interact with specific targets of cancer cells. After ingenious chemical modification and transformation, new drug molecules that can inhibit the growth and spread of cancer cells may be constructed.
In the field of materials science, due to its unique chemical structure and electronic properties, it may be used to prepare functional organic materials. For example, in the field of organic optoelectronic materials, through rational design and synthesis, materials may be endowed with unique optoelectronic properties, which can be used to fabricate light Emitting Diodes, solar cells and other optoelectronic devices to improve their photoelectric conversion efficiency and stability.
Furthermore, in the field of organic synthetic chemistry, as a nitrogen-containing heterocyclic compound, its rich reaction check point can participate in many organic reactions, such as nucleophilic substitution, cyclization reactions, etc., providing an effective way to construct complex organic molecular structures, helping organic synthesis chemists to expand the diversity of molecular structures and develop new organic compounds.

The synthesis method of 5-bromo-2-oxo-1,2-dihydropyridine-3-formonitrile, although the ancient book "Tiangong Kaiwu" does not directly describe this material, it can be compared to the process ideas in the book, and it can be deduced from common raw materials and steps.
In ancient chemical practice, common natural materials are often used as the starting point. If you want to synthesize this compound, you can first find a natural substance containing a pyridine structure as the starting material. In nature, some plant extracts or microbial metabolites may have a similar pyridine ring structure, which can be separated and purified to obtain the initial substrate.
First of all, for the construction of pyridine rings, although there were no modern complex instruments in ancient times, heating, acid-base treatment and other means could be used. Organic matter containing nitrogen and carbon, such as some nitrogen-containing heterocyclic plant bases, can be heated and reacted in an appropriate acid-base medium, or the prototype of pyridine rings can be constructed. In this process, the ancients or through repeated experiments of different natural acids and bases, such as plant ash (basic), vinegar (acidic), etc., adjusted the reaction environment and promoted the cyclization reaction.
After the pyridine ring was constructed, bromine atoms were introduced at the 5-position, and brominating agents were used in ancient times. Although there was no modern pure bromine at that time, bromine-containing substances could be extracted from seawater and salt lake brine, and the primary brominating agent could be obtained after treatment. The substrate containing the pyridine ring was reacted with the brominating agent at an appropriate temperature and solvent. The solvents used in ancient times were mostly natural organic solvents, such as alcohols (ethanol contained in rice wine, fruit wine, etc.). By controlling the reaction temperature and time, the bromine atom was selectively substituted at the 5-position.
The introduction of the 2-position carbonyl group, or by means of oxidation reaction. In ancient times, air and natural oxides (such as some metal oxides) were often used as oxidants. Under specific conditions, the 2-position of the pyridine ring was oxidized to form a carbonyl group.
As for the introduction of 3-formonitrile, cyanide-containing raw materials can be prepared first. In ancient times, cyanide sources could be obtained from some cyanide-containing plants or ores, and after treatment, they reacted with pyridine derivatives to connect the formonitrile group to the 3-position, thus completing the synthesis of 5-bromo-2-oxo-1,2-dihydropyridine-3-formonitrile. Although the ancient method is crude compared with modern science, its exploration spirit and practical ideas may provide a different perspective for the synthesis of this compound.

5-Bromo-2-oxo-1,2-dihydropyridine-3-formonitrile is one of the organic compounds. Its physical and chemical properties have a number of characteristics, let me tell you one by one.
In terms of its appearance, it is often in a solid state, but it also depends on the specific preparation and purification conditions. Its melting point is one of the important physical properties. It has been experimentally measured that it is in a certain temperature range. This temperature is crucial for the identification and purification of the compound. Due to the determination of the melting point, it can help to distinguish its purity. If impurities are present, the melting point tends to decrease and the melting range becomes wider.
As for solubility, 5-bromo-2-oxo-1,2-dihydropyridine-3-formonitrile exhibits different behaviors in organic solvents. In polar organic solvents such as dimethyl sulfoxide (DMSO), N, N-dimethylformamide (DMF), it has good solubility due to the appropriate interaction between the molecular structure and the solvent, such as hydrogen bonding, van der Waals force, etc. In non-polar solvents such as n-hexane, the solubility is very poor, because the molecule has a certain polarity and the force between it and the non-polar solvent is weak. < Br >
In terms of chemical properties, the bromine atom in this compound is active and can participate in a variety of nucleophilic substitution reactions. Due to the relatively large electronegativity of the bromine atom, the bonds connected to the carbon atom have a certain polarity, which is vulnerable to nucleophilic reagents, so as to realize the conversion of functional groups. The 2-oxo structure also affects its chemical behavior, and this carbonyl group can participate in reactions such as reduction and nucleophilic addition. Furthermore, 3-methylnitrile is also an active check point, capable of hydrolysis, addition and other series of reactions. These reaction characteristics make 5-bromo-2-oxo-1,2-dihydropyridine-3-methylnitrile show broad application prospects in the field of organic synthesis. It can be used as a key intermediate to construct more complex organic molecular structures.

5-Bromo-2-oxo-1,2-dihydropyridine-3-formonitrile, which is widely used in the fields of medicine and materials science.
In the field of medicine, it is often a key intermediate for the synthesis of many drugs. The structure of the geinpyridine ring is common in many bioactive molecules, and the functional groups such as bromine, carbonyl and cyano can be modified by various chemical reactions to endow the obtained compounds with unique biological activities. For example, it can be converted into complex heterocyclic compounds with potential pharmacological activities by reactions such as nucleophilic substitution and cyclization, which can be used to develop antibacterial, anti-inflammatory, anti-tumor and other drugs.
In the field of materials science, due to its special structure, it can participate in the preparation of functional materials. The active functional groups it contains can react with other monomers or polymers to build materials with special optical, electrical or mechanical properties. For example, in organic optoelectronic materials, after appropriate modification, the electron transport and luminescence properties of the material can be adjusted, and it is used in organic Light Emitting Diode (OLED), solar cells and other devices.
Furthermore, in the field of organic synthetic chemistry, it is also an important synthetic building block. Chemists can use ingenious design of reaction paths and use their structural characteristics to construct various complex organic molecules, expand the structural diversity of organic compounds, and lay the foundation for the creation and performance of new substances. In conclusion, 5-bromo-2-oxo-1,2-dihydropyridine-3-formonitrile has important application value in many fields and promotes the development of related science and technology.

5-Bromo-2-oxo-1,2-dihydropyridine-3-formonitrile is an organic compound. In the current market situation, it shows considerable development trend.
In terms of its application field, this compound is of great value in the field of medicinal chemistry. Many scientific research teams are committed to using it as a starting material to design and synthesize new drug molecules. Due to its specific structural units, it may exhibit unique biological activities against certain disease targets, which is why the demand for 5-bromo-2-oxo-1,2-dihydropyridine-3-formonitrile is increasing in the field of innovative drug research and development.
In the field of materials science, it has also emerged. With its special chemical structure, it may participate in the preparation of organic materials with special properties, such as optoelectronic materials. With the advancement of science and technology, the demand for high-performance and multi-functional materials is increasing. The potential application of this compound in this field has also attracted much attention, attracting the attention and research of many materials scientists, and is expected to inject new vitality into the development of materials science.
From the perspective of market supply, with the increasing demand for this compound, some chemical reagent suppliers have included it in the product list. However, due to the difficulty of the synthesis process, the supply of some high-quality and high-purity products may still be tight. On the production side, some companies with advanced organic synthesis technology are trying to optimize the synthesis route to improve production and quality and meet the growing market demand. Overall, 5-bromo-2-oxo-1,2-dihydropyridine-3-formonitrile has shown broad application prospects in the fields of medicine and materials. Although the current market supply faces some challenges, with the deepening of research and technological innovation, its market development space is considerable, and it is expected to become an important compound to promote the development of related fields in the future.