5-Bromo-2-n-butoxypyridine

5-Bromo-2-n-butoxy pyridine, this is an organic compound. It has specific chemical properties, let me explain in detail.
In terms of its physical properties, it is mostly liquid or solid at room temperature, but the exact state often varies according to environmental conditions. The characteristics of its melting point and boiling point are also closely related to the molecular structure. The presence of bromine atoms and n-butoxy groups in the molecule gives it unique physical properties. Bromine atoms are relatively heavy and have certain electronegativity, while n-butoxy groups are longer carbon chains. The synergistic effects of the two make their physical properties such as melting and boiling points different from ordinary pyridine compounds.
When it comes to chemical properties, bromine atoms are active and can participate in many chemical reactions. For example, nucleophilic substitution reactions, bromine atoms are easily replaced by nucleophilic reagents. Because bromine atoms are connected to pyridine rings, the electron cloud distribution of pyridine rings is affected by bromine atoms, making bromine atoms easier to leave. Nucleophilic reagents such as alkoxides and amines can attack the location of bromine atoms, replace them, and form new compounds, which are widely used in the field of organic synthesis.
In addition, pyridine rings are also reactive. Pyridine rings are weakly basic, and can react with acids or electrophilic reagents because of the lone pair electrons on nitrogen atoms. In 5-bromo-2-n-butoxy pyridine, the alkalinity of the pyridine ring may be changed by the substitution of the bromine atom and the n-butoxy group. In addition, the pyridine ring can undergo electrophilic substitution reaction, but the reaction check point may be different from that of ordinary pyridine. The localization effect of the bromine atom and the n-butoxy group will affect the attack position of the electrophilic reagent.
The presence of n-butoxy groups also plays an role in the chemical properties of the compound. Long-chain n-butoxy groups can enhance the lipid solubility of the compound and affect its solubility in different solvents. And the carbon-oxygen bond on the n-butoxy group can also undergo reactions such as cracking under specific conditions, participating in the organic reaction process. In conclusion, the chemical properties of 5-bromo-2-butoxy pyridine are rich and diverse, and it has potential application value in many fields such as organic synthesis.

5-Bromo-2-n-butoxy pyridine has a wide range of uses in the field of organic synthesis. First, it is often a key intermediate in medicinal chemistry. During drug development, through specific reactions, various functional groups can be introduced on its structure, and then compounds with specific pharmacological activities can be constructed. For example, using it as a starting material, by means of nucleophilic substitution reactions, groups containing heteroatoms such as nitrogen and oxygen can be connected to create drugs for the treatment of cardiovascular diseases, neurological diseases, etc.
Second, it is also useful in the field of materials science. After modification and polymerization, materials with special photoelectric properties can be prepared. For example, by incorporating it into a conjugated polymer system, the electronic structure and optical properties of the polymer can be adjusted, and it is expected to be used in the preparation of optoelectronic devices such as organic Light Emitting Diodes (OLEDs) and solar cells.
Third, in the study of organic synthesis methodologies, 5-bromo-2-n-butoxy pyridine can be used as a model substrate to explore new reaction pathways and catalytic systems. Chemists use this to study metal-catalyzed coupling reactions, such as Suzuki coupling and Heck coupling, which provide a basis and example for expanding organic synthesis strategies and promote the development of organic synthesis chemistry.

There are several common methods for the synthesis of 5-bromo-2-n-butoxy pyridine.
First, 2-hydroxypyridine is used as the starting material. First, 2-hydroxypyridine is reacted with n-butyl halides, such as n-butyl bromide, under alkaline conditions. The base can be selected from potassium carbonate, etc., in a suitable solvent, such as N, N-dimethylformamide (DMF), heated and stirred. This reaction is a nucleophilic substitution reaction. Hydroxyl oxygen atoms attack the carbon atoms of n-butyl halides as nucleophiles, and the halogen atoms leave to form 2-n-butoxy pyridine. Subsequently, 2-n-butoxy pyridine is brominated. A brominating agent, such as N-bromosuccinimide (NBS), can be used to heat the reaction in a solvent such as carbon tetrachloride in the presence of an initiator, such as benzoyl peroxide. NBS provides bromine radicals, which attack the appropriate position on the pyridine ring to generate 5-bromo-2-n-butoxy pyridine.
Second, 2-chloropyridine is used as the starting material. First, it undergoes a nucleophilic substitution reaction with n-butanol under the action of a basic catalyst such as sodium hydroxide, and the chlorine atom is replaced by n-butoxy to generate 2-n-butoxy pyridine. After that, according to the above bromination method, bromide with NBS and other reagents to obtain the target product.
Third, 5-bromo-2-hydroxypyridine is used as the raw material. Under conditions similar to the above nucleophilic substitution reaction, the alkali catalyzes the reaction in a suitable solvent, and the hydroxyl group is replaced by the n-butoxy group to directly synthesize 5-bromo-2-butoxy pyridine. This method is relatively simple. If 5-bromo-2-hydroxypyridine is easy to obtain, it is a good choice. Different synthetic methods have their own advantages and disadvantages, and it is necessary to comprehensively consider factors such as the availability of raw materials, the difficulty of reaction conditions, and the cost to choose the most suitable method.

5-Bromo-2-n-butoxy pyridine is also an organic compound. Its market price often changes over time and varies depending on many factors.
In the past chemical market, the price of such compounds was determined by the abundance of raw materials, the difficulty of preparation, and the amount of demand. If the raw materials are sufficient, the preparation method is simple, and the supply exceeds the demand, the price will decline. On the contrary, the raw materials are scarce, the preparation is difficult, and the demand is strong, and the supply is in short supply, the price will rise.
And it is used in various fields of chemical industry, and it is widely used. In the way of pharmaceutical synthesis, it is often a key intermediate, helping to create new drugs. In the field of material science, it may also be an important raw material to make special materials. Different uses have different needs, and the impact of this on prices should not be underestimated.
Check the historical chemical materials in the past, and the prices of similar compounds may vary depending on the place of origin. Locally produced, if there is no tariff and freight burden, the price may be slightly lower. And imported products, with taxes and freight, the price will increase. And the competitive situation of the market also affects its price. There are many merchants, and the competition is fierce, they will reduce the price in order to compete for the market; if there are few merchants, they will be able to control the price and make a big profit.
In summary, in order to know the current market price of 5-bromo-2-n-butoxy pyridine, it is necessary to examine the raw material market, production status, demand situation, origin differences and competition landscape in real time.

5-Bromo-2-n-butoxy-pyridine is a chemical commonly used in organic synthesis. When storing and transporting, it is necessary to pay attention to many key points to ensure its quality and safety.
First words storage. This substance should be stored in a cool, dry and well-ventilated place. The cover is very sensitive to humidity and temperature, and high temperature and humid environment can easily cause chemical reactions to occur, resulting in damage to quality. When the humidity is high, it may cause reactions such as hydrolysis, which affects its chemical structure and purity. If the temperature is too high, it may accelerate its decomposition rate. Therefore, it is essential to choose a suitable storage environment. Keep away from fire, heat sources, and prevent direct sunlight. Many chemical substances will cause luminescent chemical reactions under light conditions, and the same is true for 5-bromo-2-n-butoxy pyridine. Light may cause its molecular structure to change, reducing its purity and stability. At the same time, it should be stored separately from oxidants, acids, bases, etc., and should not be mixed. Because of its active chemical properties, contact with these substances is prone to violent chemical reactions, and even cause danger.
Further transportation. During transportation, ensure that the container is well sealed to prevent leakage. If 5-bromo-2-n-butoxy pyridine leaks, it will not only cause material loss, but also pose a hazard to the environment and may also endanger the safety of transporters. Transportation vehicles should be equipped with the corresponding variety and quantity of fire fighting equipment and leakage emergency treatment equipment. In the event of leakage or fire and other accidents, timely response measures can be taken to reduce losses and hazards. When transporting, follow the specified route and do not stop in densely populated areas and residential areas. This can avoid large-scale casualties and environmental pollution in the event of accidents in crowded places. Load and unload lightly to prevent damage to packaging and containers. Rough handling can easily cause containers to break and cause leaks and other problems. In conclusion, when storing and transporting 5-bromo-2-n-butoxy pyridine, it is necessary to strictly follow relevant norms and requirements, paying attention to environmental conditions, isolated storage, sealed transportation, emergency preparedness, and many other aspects to ensure its safety and quality.