5-Bromo-2-methylpyridine

5-Bromo-2-methylpyridine is also an organic compound. It has a wide range of uses and is a key intermediate in the field of pharmaceutical synthesis. It can prepare antibacterial and anti-inflammatory drugs. By combining with other reagents through specific reactions, complex drug molecular structures can be constructed to treat various diseases.
It also plays an important role in the creation of pesticides. It can be chemically converted into pesticide ingredients with high insecticidal and bactericidal properties to protect crops from pests and pathogens and increase agricultural output.
In the field of materials science, 5-bromo-2-methylpyridine can be used to prepare special polymer materials. Due to its unique structure, it can endow materials with specific electrical and optical properties, and develop its strengths in organic optoelectronic materials, such as for the manufacture of optoelectronic devices such as organic Light Emitting Diodes, to improve their performance.
In addition, in the study of organic synthetic chemistry, it is often used as a substrate or reagent. Chemists can use its bromine atom and methyl activity to carry out various chemical reactions, explore novel synthesis paths, expand the types and properties of organic compounds, and lay the foundation for technological innovation in many fields. In short, 5-bromo-2-methylpyridine has indispensable functions in many fields due to its unique chemical properties.

5-Bromo-2-methylpyridine is also an important intermediate in organic synthesis. Its synthesis method has followed various paths in the past.
First, 2-methylpyridine is used as the starting material and obtained by bromination reaction. In this reaction, liquid bromine or N-bromosuccinimide (NBS) is often used as the bromine source. If liquid bromine is used, in an appropriate solvent such as dichloromethane, add an appropriate amount of catalyst, such as iron powder or iron tribromide, and conduct the reaction under temperature control. Liquid bromine has high activity and the reaction is easy to occur. However, it is necessary to pay attention to its corrosiveness and reaction selectivity. If NBS is used as the bromine source, the reaction conditions are relatively mild, and the bromine radical generated by NBS can better realize the bromination of specific positions on the pyridine ring.
Second, it is prepared by the conversion of pyridine derivatives. For example, pyridine derivatives containing appropriate substituents are first prepared, and then a series of functional group transformations are carried out to gradually introduce bromine atoms and methyl groups. For example, 2 - (protective group) pyridine is synthesized first, and then methyl is introduced under suitable conditions, followed by deprotection and bromination. Although this process is slightly complicated, it may be beneficial to control the reaction conditions and the selectivity of the product.
Third, the cross-coupling reaction using metal catalysis. The target product is obtained by using bromine-containing pyridine derivatives and methyl-containing reagents under the action of metal catalysts such as palladium catalysts to realize the coupling of carbon-carbon bonds. This method requires the selection of suitable ligands and bases to promote the smooth progress of the reaction, and the requirements for the structure and reaction conditions of the reaction substrate are stricter, so that compounds with specific structures can be effectively constructed.
These several synthesis methods have their own advantages and disadvantages. In practical application, when considering factors such as the availability of raw materials, the difficulty of controlling the reaction conditions, and the purity and yield of the product, the appropriate method is selected.

5-Bromo-2-methylpyridine is one of the organic compounds. It has unique physical properties. Looking at its appearance, it is a colorless to light yellow liquid under normal conditions, and this color state is its significant expression.
When talking about the boiling point, it is between 193-194 ° C. The boiling point is the specific temperature at which a substance changes from a liquid state to a gas state. This value indicates that under this temperature condition, the change of intermolecular forces causes the phase state of the substance to change.
Furthermore, the melting point is about -30 ° C. The melting point is the critical temperature at which a solid is converted to a liquid, reflecting the stability of the lattice structure of the substance in the solid state and the strength of the intermolecular forces.
Its density is about 1.45 g/cm ³, the density is the mass per unit volume of the substance, and this value reflects the compactness of its molecular packing.
5-Bromo-2-methyl pyridine is slightly soluble in water, and this solubility is due to the interaction between the polar and non-polar parts of its molecular structure. Pyridine rings have certain hydrophobicity with methyl groups, while bromine atoms have a certain polarity, but the polarity of the whole molecule is not enough to form a strong interaction with water molecules, so it is only slightly soluble in water. However, it is soluble in organic solvents such as ethanol and ether, because these organic solvents and 5-bromo-2-methylpyridine molecules can form similar intermolecular forces, following the principle of "similar phase dissolution".
In addition, the compound has a certain volatility, and under normal temperature, some molecules can break free from the shackles of the liquid surface and enter the gas phase. Its vapor has a specific odor, although it is difficult to describe accurately, it is often irritating. When using, pay attention to ventilation to prevent discomfort to the human body.

5-Bromo-2-methylpyridine is also an organic compound. It has the versatility of halogenated pyridine substances, is active and can involve a variety of chemical reactions.
In this compound, bromine atoms are highly active. Due to its strong electronegativity, bromine causes C-Br bond polarization, which is easy to be attacked by nucleophiles, and then triggers nucleophilic substitution reactions. If reacted with sodium alcohol, bromine can be replaced by alkoxy groups to form corresponding ethers. It can also interact with amines, and bromine is replaced by amino groups to obtain nitrogen-containing derivatives, which are widely used in the synthesis of medicine and pesticides.
Furthermore, its methyl groups are also reactive. Under appropriate conditions, methyl can be oxidized, and if it is acted by a strong oxidant, it can be converted into carboxyl groups to form 5-bromo-2-pyridinecarboxylic acid.
In addition, the pyridine ring of 5-bromo-2-methyl pyridine has aromatic properties, and the electron cloud distribution is special. The nitrogen atom of the pyridine ring has lone pairs of electrons, is basic, and can form salts with acids. And because of its uneven electron cloud density, it can undergo electrophilic substitution reactions, but the activity is lower than that of the benzene ring, and the substitution is mostly in the β-position of the pyridine ring (relative to the nitrogen atom), such as nitrification, sulfonation and other reactions. Due to its structural properties, 5-bromo-2-methylpyridine is an important intermediate in the field of organic synthesis, and many compounds with biological activity and special functions can be prepared through various reactions.

It is difficult to determine the price range of 5-bromo-2-methylpyridine in the market. Changes in the cap price often depend on various factors.
First, the price of raw materials is also. If the raw materials required for synthesizing this substance are difficult to obtain and the amount of output varies, the price of 5-bromo-2-methylpyridine will fluctuate. If the raw materials are rare and difficult to obtain, the price of the finished product will be high; if the raw materials are abundant and easier to obtain, the price may decrease.
Second, the preparation method also has an impact. Different preparation processes have different costs. An efficient and low-cost method can reduce the price of production; a cumbersome and time-consuming method will result in high prices.
Third, the supply and demand of the city is also the key. If there are many people who need this material, but the production is insufficient, the price will rise; if the supply exceeds the demand, the manufacturer wants to sell its goods quickly, and the price may fall.
Fourth, the difference in region also affects the price. In places where the chemical industry is prosperous, due to the large number of producers, the competition is intense, and the transportation is convenient, the price may be slightly lower; in remote places, due to the high transportation cost, the supply is inconvenient, and the price may be higher. < Br >
According to common sense, the price of 5-bromo-2-methylpyridine is between tens and hundreds of yuan per gram. However, this is only a rough estimate, and the actual price depends on the specific time, place and market conditions. To know the exact price, you need to consult the chemical product supplier, or refer to the professional chemical product price list.