5-Bromo-2-methylpyridine-N-oxide

5-Bromo-2-methylpyridine-N-oxide is an important compound in organic chemistry. Its chemical properties are unique and have a variety of interesting characteristics.
From the structural point of view, this compound contains bromine atoms, methyl and pyridine-N-oxide structures. Pyridine rings are aromatic, which endows the compound with certain stability. Bromine atoms are strong electron-absorbing groups, which can affect the distribution of molecular electron clouds and change its chemical activity. Methyl groups are the power supply groups, which have a certain influence on the electron cloud density of pyridine rings. The interaction between the two makes the molecular properties complex.
In terms of reactivity, 5-bromo-2-methylpyridine-N-oxide is prone to nucleophilic substitution reactions due to the presence of bromine atoms. Nucleophilic reagents can attack bromine atoms to connect carbon atoms, replace bromine groups, and form new derivatives. For example, when reacted with sodium alcohol, bromine can be replaced by alkoxy groups to form new carbon-oxygen bonds and synthesize ether compounds.
The pyridine-N-oxide part is also reactive. Its oxygen atoms are partially negatively charged and can react with electrophilic reagents. Under specific conditions, oxidation or electrophilic substitution reactions can occur to introduce new functional groups on the pyridine ring. At the same time, this structure can enhance molecular polarity and affect its solubility and reaction selectivity.
Although methyl has relatively weak power supply, it can change the molecular spatial structure and electron cloud distribution, and affect the physical and chemical properties of compounds. For example, it affects the physical properties such as molecular melting point, boiling point and solubility, and affects the selectivity of reaction check point in the reaction.
5-bromo-2-methylpyridine-N-oxide has rich chemical properties and can be used as a key intermediate in the field of organic synthesis. Through rational design of reactions, various complex organic molecules can be constructed, providing an important material basis for the research of organic chemistry and the development of related fields.

5-Bromo-2-methylpyridine-N-oxide has a wide range of uses. It is a key intermediate for the synthesis of many drugs in the field of medicine. For example, the preparation of some antibacterial drugs, through its unique structure, participates in the reaction, helps to build a drug activity skeleton, enhances the antibacterial activity and specificity of drugs, and is of great significance for the treatment of bacterial infections.
In the pesticide industry, it also plays an important role. It can be used to create new pesticides, such as some pesticide varieties with high insecticidal and bactericidal properties. Due to its chemical properties, it can make pesticides easier to adhere to target organisms, improve the efficacy of drugs, and reduce the impact on the environment, which is in line with the development direction of green pesticides.
In the field of organic synthesis, It can be used to guide specific position reactions to achieve precise synthesis of complex organic compounds. Due to its pyridine ring and oxide structure, it can activate specific sites, making the reaction more selective, helping chemists synthesize organic molecules that are difficult to obtain by conventional methods, and promoting the development of organic synthesis chemistry.
In the field of materials science, after rational design and modification, it can be used as a building block of functional materials. If used to prepare materials with specific optical and electrical properties, it shows potential application value in the field of optoelectronics, providing new ideas and approaches for the development of new optoelectronic materials.

There are several common methods for preparing 5-bromo-2-methylpyridine-N-oxide. First, it can be started from 2-methylpyridine, first oxidized with an appropriate oxidant, such as m-chloroperoxybenzoic acid (m-CPBA), under suitable reaction conditions to obtain 2-methylpyridine-N-oxide, and then reacted with a brominating agent, such as N-bromosuccinimide (NBS), in a suitable solvent, such as carbon tetrachloride, under heating or lighting conditions to obtain the target product. In this process, the oxidation step needs to pay attention to the reaction temperature and the amount of oxidant to prevent excessive oxidation; the bromination step should pay attention to the control of reaction conditions to avoid side reactions.
Second, 5-bromo-2-methyl pyridine can also be used as raw material, and suitable oxidants, such as hydrogen peroxide and acetic acid mixed system, can be used to carry out oxidation reaction in the presence of catalyst. This method requires fine regulation of catalyst type and dosage, reaction temperature and time to improve the reaction yield and selectivity. Factors such as the concentration and dosage of hydrogen peroxide and the ratio of acetic acid will have a significant impact on the reaction process and results.
Another way is to introduce appropriate substituents into the construction of the pyridine ring first, and through multi-step reactions, the synthesis of 5-bromo-2-methylpyridine-N-oxide is finally achieved. However, this route is often complicated, and each step of the reaction needs to be strictly controlled to ensure the smooth progress of the reaction, and the separation and purification of intermediate products is also quite critical, which requires high synthesis skills. In short, all methods have advantages and disadvantages, and the appropriate synthesis path must be selected according to the actual situation, such as raw material availability, cost, target product purity requirements, etc.

5-Bromo-2-methylpyridine-N-oxide is a chemical substance. When storing and transporting, it is necessary to exercise caution and follow specific regulations to ensure safety.
First storage, this substance should be placed in a cool, dry and well-ventilated place. Avoid direct sunlight, which may cause changes in chemical properties due to light or even cause adverse changes such as decomposition. Temperature should be controlled within a reasonable range. Excessive temperature can enhance its reactivity and cause danger; too low temperature may also affect its physical properties, such as crystallization, which will cause inconvenience to subsequent use.
Furthermore, the storage place should be kept away from fire, heat sources and all kinds of flammable and combustible materials. Due to the characteristics of its chemical structure, in case of open flames, hot topics, etc., there may be a risk of combustion or explosion. It should also be stored separately from oxidizing agents, acids, alkalis, etc., because different chemical substances are prone to chemical reactions, or generate harmful products, or cause violent reactions, endangering safety.
As for transportation, it is necessary to ensure that the packaging is intact. Packaging materials should meet relevant standards and can withstand certain external shocks and environmental changes to prevent material leakage. Transportation vehicles should also be clean, dry, and free of other chemical substances to avoid reactions with them. During transportation, drivers should drive slowly to avoid violent actions such as sudden braking and sharp turns, and prevent packaging damage. And the temperature and humidity of the transportation environment should also be carefully controlled, echoing the storage requirements, to ensure the stability of the material properties.
In addition, whether it is storage or transportation, it is necessary to have a clear and clear label, indicating the name of the substance, nature, hazard characteristics and emergency treatment methods. In the event of an accident, others can quickly take appropriate measures to reduce the harm. Professionals should also be professionally trained to be familiar with its characteristics and safety operating procedures to ensure operation compliance and ensure the safety of storage and transportation.

The market price range of 5-bromo-2-methylpyridine-N-oxide varies due to many factors, making it difficult to determine directly. This compound is widely used in chemical, pharmaceutical and other fields, and its price is affected by various factors such as raw material cost, preparation process, and market supply and demand situation.
Looking back at the past, raw material cost was the cornerstone of price formation. If the price of the raw materials required for the preparation of 5-bromo-2-methylpyridine-N-oxide fluctuates due to origin, age, market fluctuations, etc., the cost of 5-bromo-2-methylpyridine-N-oxide will also change, and the final price will be reflected in the market price. The simplicity, difficulty and efficiency of the preparation process are also related to cost and price. Efficient and low-cost processes can reduce production costs or make prices lower; conversely, complex and inefficient processes will push up costs and prices.
Market supply and demand trends have a deep impact on prices. If the chemical and pharmaceutical industries have strong demand for 5-bromo-2-methylpyridine-N-oxide and limited supply, prices tend to rise; conversely, if demand is weak and supply is excessive, prices may drop.
Overall, the market price of 5-bromo-2-methylpyridine-N-oxide fluctuates in the past. Roughly speaking, its price often fluctuates between tens of yuan and hundreds of yuan per kilogram. But this is only an approximate number. The actual price may rise or fall sharply due to the above factors, and it needs to be determined according to the current market conditions.