5-Bromo-2-methyLpyridine-3-amine

5-Bromo-2-methylpyridine-3-amine is one of the organic compounds. Its physical properties are related to the characterization and basic characteristics of the substance, and are important for chemical research.
In terms of its properties, under normal temperature and pressure, it mostly shows the appearance of a solid state. Due to the force between molecules, its molecules are arranged in an orderly manner and maintain a solid state structure. Looking at its color, it often appears white to white powder, and when it is pure, the color is uniform, which is a sign of its significant appearance.
As for the melting point, it is about a specific temperature range. This temperature is the critical value for its transformation from a solid state to a liquid state, determined by the strength of intermolecular interactions. The accurate determination of the melting point is crucial for the identification of the compound and the evaluation of purity. Generally speaking, the value of the melting point is relatively stable, and if impurities are contained, the melting point is often reduced and the melting range is widened.
In terms of solubility, 5-bromo-2-methylpyridine-3-amine exhibits different solubility characteristics in common organic solvents. In polar organic solvents such as ethanol, dichloromethane, etc., it has a certain solubility. Because the molecule is partially polar, hydrogen bonds and dipole-dipole interactions can be formed with polar solvent molecules, which help it disperse in the solvent. However, in non-polar solvents such as n-hexane, the solubility is poor, because the molecular polarity does not match the non-polar solvent, and the intermolecular force is difficult to overcome the original intermolecular force of the solvent.
Furthermore, its density is also an important physical property. Although the specific value is accurately determined by experiments, the approximate range reflects the difference in unit volume mass between it and other substances. The characteristics of density have reference value in the process of material separation and mixing.
The physical properties of 5-bromo-2-methylpyridine-3-amine, such as properties, color, melting point, solubility and density, are the basis for in-depth understanding of this compound, and are of great significance in chemical synthesis, analytical identification and related application fields.

5-Bromo-2-methylpyridine-3-amine, this is an organic compound with unique chemical properties. In its structure, bromine atom, methyl and amino coexist in a pyridine ring. Due to its special structure, it exhibits a variety of chemical activities.
Let's talk about the nucleophilic substitution reaction first. Bromine atoms have high activity and are often the target of nucleophilic reagents. In case of hydroxyl negative ions, bromine can be replaced by hydroxyl groups to form hydroxyl-containing pyridine derivatives. This reaction is commonly used in the synthesis of compounds with hydroxyl functional groups.
Let's talk about alkalinity. The presence of amino groups makes the compound alkaline to a certain extent. The amino nitrogen atom has a lone pair of electrons, which can bind protons. In an acidic environment, it is easy to react with protons to form salts. This basic property is crucial for regulating the solubility and stability of drugs in medicinal chemistry.
has redox properties, and the pyridine ring can participate in the redox reaction. Under specific oxidation conditions, the pyridine ring can be oxidized to obtain oxidized pyridine derivatives; conversely, under suitable reduction conditions, the pyridine ring can also be reduced, the structure is changed, and the properties are different.
In addition, due to the electron push effect of methyl groups, the distribution of the electron cloud of the pyridine ring will be affected, and the density of the electron cloud at a specific position on the ring will change, thereby affecting the electrophilic substitution reaction activity and check point The chemical properties of 5-bromo-2-methylpyridine-3-amine make it widely used in organic synthesis, drug development and other fields. According to its properties, chemists can skillfully design reactions and prepare desired compounds.

5-Bromo-2-methylpyridine-3-amine is a common compound in organic synthesis. There are many different methods of synthesis, and one or two of the common ones mentioned above.
First, the corresponding pyridine derivative can be started. First take the pyridine containing the appropriate substituent and carry out the bromination reaction with a brominating reagent. Commonly used brominating reagents, such as bromine ($Br_2 $), in the presence of suitable catalysts, such as iron powder or iron tribromide, can cause bromination at specific positions on the pyridine ring. In this example, the 5-position of the pyridine ring is introduced into the bromine atom. Then, the 2-position is methylated, and a suitable methylation reagent can be selected, such as iodomethane ($CH_3I $) interacting with a base, under appropriate reaction conditions, the 2-position is successfully introduced into the methyl group. Then, through a suitable amination reaction, the amino group is introduced at the 3-position. An ammonia source and appropriate reaction conditions can be selected to achieve this conversion.
Second, it can also be started from another angle. Take pyridine containing a specific substituent as the raw material, first carry out an amination reaction on it, and introduce an amino group at the 3-position of the pyridine ring. Appropriate amination reagents and reaction conditions can be selected for this process. Subsequently, the methylation reaction is carried out, and methyl is introduced at the 2-position. Finally, the bromination reaction occurs at the 5-position with a brominating reagent to obtain 5-bromo-2-methylpyridine-3-amine.
When synthesizing, attention should be paid to the conditions of each step of the reaction. Temperature, reaction time, and the proportion of reactants all have a great influence on the reaction results. After each step of the reaction, it is often necessary to separate and purify to obtain a high-purity product. In this way, after multiple steps of careful reaction operation, the target compound 5-bromo-2-methylpyridine-3-amine can be obtained.

5-Bromo-2-methylpyridine-3-amine is useful in various fields. This compound has great functions in the field of medicinal chemistry. Due to its special structure, it can be used as a key intermediate for the synthesis of many drugs. During drug development, chemists may use it to build molecular structures with specific biological activities to find effective therapies for specific diseases, such as in the development of anti-cancer drugs, or to build drug molecules that can precisely act on cancer cell targets.
In the field of materials science, it also has potential applications. When preparing organic electronic materials, 5-bromo-2-methylpyridine-3-amine may participate in the synthesis of organic materials with special electrical properties. Due to the combination of pyridine rings with amine groups and bromine atoms, or the unique electronic conductivity properties of the materials, it is used to prepare organic Light Emitting Diodes (OLEDs), organic field effect transistors (OFETs) and other devices to improve their performance.
Furthermore, in the field of agricultural chemistry, it can also be used. It can be used as a raw material for the synthesis of new pesticides, chemically modified to create pesticide products with high pest killing effect and environmental friendliness, which can help agricultural pest control and ensure crop harvest.
In summary, 5-bromo-2-methylpyridine-3-amine has shown important application potential in many fields such as medicine, materials, and agriculture due to its unique chemical structure, providing new opportunities and approaches for the development of many fields.

The market price of 5-bromo-2-methylpyridine-3-amine is difficult to determine. Although this compound is useful in the chemical industry, its price is determined by many factors.
First, the cost of raw materials is crucial. The price fluctuations of various starting materials required to produce this substance have a significant impact on the selling price of the final product. If raw materials are scarce, or the process of obtaining and purifying them is complicated and costly, the price of 5-bromo-2-methylpyridine-3-amine will also rise.
Second, the ease and cost of the preparation process are also key. If the synthesis route is lengthy, multiple steps are required, and the yield of each step is not high, or the reaction conditions are harsh, and special equipment, catalysts, etc. are required, the production cost will increase, which will be reflected in the market price.
Furthermore, the market supply and demand relationship is a major variable. If there is strong demand for it in many industries, such as pharmaceutical research and development, material science and other fields, there will be continuous and large demand for it, and the supply is relatively insufficient, the price will inevitably rise; conversely, if the demand is limited and the supply is abundant, the price may stabilize or even decline.
In addition, the size of the manufacturer and regional differences also have an impact. Large-scale manufacturers may be able to control costs due to scale effects, and prices may have advantages; economic conditions, tax policies, transportation costs and other factors in different regions will also make the same compound present different prices in different markets.
Therefore, in order to determine the exact market price of 5-bromo-2-methylpyridine-3-amine, it is necessary to carefully check the raw material market dynamics, production process progress, current supply and demand situation, and quotations of various manufacturers, and comprehensively weigh them to obtain more accurate price information.