5-Bromo-2-methylpyridine 1-oxide

5-Bromo-2-methylpyridine-1-oxide is an important compound in the field of organic chemistry. It has unique chemical properties and plays a key role in many reactions in organic synthesis.
Looking at its structure, the 5-position bromine atom, the 2-position methyl and the oxygen atom on the pyridine ring all have a significant impact on its chemical activity and reaction tendency. Bromine atoms have good departure properties due to their high electronegativity, which often makes the compound easy to participate in nucleophilic substitution reactions. Nucleophiles can attack the carbon atom attached to the bromine atom and replace bromine, which is a common way to construct new carbon-carbon bonds or carbon-hetero bonds.
The methyl group at the 2 position can change the electron cloud density distribution of the pyridine ring due to the electron supply effect. The electron cloud density of the pyridine ring increases relatively, which in turn affects its reactivity with electrophilic or nucleophilic reagents. At the same time, the presence of methyl groups also contributes to the spatial structure and stereochemical properties of the molecule, and affects the reaction process and product selectivity in some reactions involving spatial steric resistance. The oxygen atom on the pyridine ring exists in the form of N-oxide, which further changes the electron cloud distribution of the pyridine ring. This structural characteristic makes the compound not only have the basic characteristics of pyridine compounds, but also exhibit unique reactivity due to the presence of oxygen atoms. The N-oxide form can enhance the reactivity of pyridine ring to electrophilic reagents. Compared with ordinary pyridine, it is more prone to electrophilic substitution reaction, and the reaction check point is often affected by the combination of oxygen atoms and other substituents.
In addition, 5-bromo-2-methylpyridine-1-oxide also exhibits specific properties in redox reactions. Due to the electron cloud distribution and chemical bond characteristics of each atom in the structure, it can participate in the oxidation or reduction process to realize the transformation of molecular structure and the modification of function. In the practical application of organic synthesis, chemists can skillfully utilize the above chemical properties of 5-bromo-2-methylpyridine-1-oxide to design and implement various reaction routes to prepare various organic compounds with specific structures and functions, providing important synthetic building blocks for the development of many fields such as medicinal chemistry and materials science.

There are many methods for the synthesis of 5-bromo-2-methylpyridine-1-oxide. First, 2-methylpyridine is used as the starting material, and 2-methylpyridine-1-oxide is first oxidized to obtain 2-methylpyridine-1-oxide. In this step, peroxides, such as m-chloroperoxybenzoic acid, are commonly used in suitable solvents, such as dichloromethane, and the temperature control reaction can obtain a higher yield of 2-methylpyridine-1-oxide. Then, it is reacted with a brominating reagent. The brominating reagent can be N-bromosuccinimide (NBS). In the presence of an initiator such as benzoyl peroxide, it is heated and refluxed in a solvent such as carbon tetrachloride, and the radical substitution reaction is carried out to obtain 5-bromo-2-methylpyridine-1-oxide.
Second, 5-bromo-2-methylpyridine is used as a raw material for direct oxidation. Commonly used oxidation reagents include hydrogen peroxide, which is heated in an acidic medium such as acetic acid. However, this approach needs to pay attention to the control of reaction conditions to prevent excessive oxidation or side reactions.
Furthermore, there are also pyridine derivatives as the starting materials, and the target product is constructed through multi-step reaction. First, the pyridine ring is appropriately modified, methyl and bromine atoms are introduced, and then the oxidation step is carried out to achieve the synthesis of 5-bromo-2-methyl pyridine-1-oxide. However, there are many steps in this route, and each step of the reaction needs to be carefully planned to ensure the high efficiency and high selectivity of the overall synthesis.

5-Bromo-2-methylpyridine-1-oxide is useful in many fields.
In the field of medicinal chemistry, it is a key raw material for the synthesis of delicate drug molecules. Due to the unique electronic properties and reactivity of pyridine oxide structure, it can be added with various functional groups through specific chemical reactions to obtain compounds with special pharmacological activities. Or act on specific biological targets, paving the way for the development of new therapeutic drugs, such as anti-cancer and anti-infection drugs.
In the field of materials science, it also shows unique value. Can participate in the preparation of functional materials with special properties, such as optoelectronic materials. By chemically modifying and assembling it, the electron transport properties and optical properties of materials can be regulated, and it plays an important role in the fabrication of organic Light Emitting Diodes, solar cells and other devices.
Furthermore, in the field of organic synthesis chemistry, it is a powerful intermediate. It can trigger a variety of organic reactions, such as nucleophilic substitution, redox, etc. Chemists can design and construct complex organic molecular structures according to their reaction characteristics, injecting impetus into the development of organic synthesis chemistry. Its unique chemical structure and reactivity are like a key to open the door to synthesizing novel organic compounds and promote organic synthesis chemistry to new frontiers.
This compound plays an indispensable role in many fields such as medicine, materials, and organic synthesis, providing a key boost for progress and innovation in various fields.

The market price of 5-bromo-2-methylpyridine-1-oxide is difficult to determine due to various market conditions. Looking back at the past, the market price of such compounds was often influenced by various factors. The key factors were the source of raw materials, the difficulty of preparation, the boom and bust in demand, and the competition in the market.
If the raw materials are abundant and easy to produce, the preparation method is simple and easy, the cost is reduced, and the market price may become easier. On the contrary, if the raw materials are scarce, the preparation process is complicated, and a lot of manpower and material resources are required, the price will be high.
The demand side is also the key. If a certain field is eager for the compound at a certain time, and it is used by the pharmaceutical, chemical and other industries, its price may rise. On the contrary, if the demand is weak, the price will also drop accordingly.
Furthermore, the competition in the market should not be underestimated. If there are many people in the same industry who want to sell their goods, they must compete with the price, and the price may fall because of it. However, if only a few companies operate, it is oligopolistic, and the price may be controllable at a high level.
If you want to know the exact price, you should carefully examine the current market conditions, consult the merchants of chemical raw materials, or check the special market situation reports, in order to obtain a more accurate number. It is impossible to just follow the past, but you need to check the changes in the market at any time to get the accurate market price.

5-Bromo-2-methylpyridine-1-oxide is an important compound in the field of organic chemistry. Its physical properties are particularly critical and have a significant impact on its performance in various chemical processes and industrial applications.
Looking at its properties, under normal temperature and pressure, 5-bromo-2-methylpyridine-1-oxide is often in a solid state, mostly white to light yellow crystalline powder, which makes it easy to handle and store. Its melting point value is about a specific range, specifically, the melting point is between [X] ° C and [X] ° C. The melting point data is of great significance in the purity identification and separation and purification process of compounds.
When it comes to solubility, this compound exhibits certain solubility properties in organic solvents. In common organic solvents such as ethanol and acetone, it has moderate solubility and can dissolve to form a uniform solution. This property provides various possibilities for solvent selection in organic synthesis reactions. However, its solubility in water is relatively limited, only slightly soluble in water, mainly due to the influence of hydrophobic groups in its molecular structure.
Speaking of density again, 5-bromo-2-methylpyridine-1-oxide has a specific density value, which is about [X] g/cm ³. The physical property of density cannot be ignored in the study of precise measurement and mixing systems, which helps to control the proportion of reactants and the physical state of the system.
In addition, the stability of this compound is also worthy of attention. Under normal storage and use conditions, 5-bromo-2-methylpyridine-1-oxide exhibits relatively stable characteristics. However, under extreme conditions such as high temperature, strong oxidizing agents or strong acids and bases, its chemical structure may change, triggering decomposition or other chemical reactions.
In summary, the physical properties of 5-bromo-2-methylpyridine-1-oxide, including properties, melting point, solubility, density, and stability, together constitute its unique physical and chemical properties, providing a solid foundation for its application in many fields such as organic synthesis and medicinal chemistry.