5-Bromo-2-methoxypyridine

5-Bromo-2-methoxypyridine is also an organic compound. It has unique physical properties and is worth exploring.
Looking at its properties, under normal temperature and pressure, 5-bromo-2-methoxypyridine is mostly colorless to light yellow liquid, with a clear appearance and a certain fluidity. Its odor is specific, not pungent and unpleasant, but it is also unique, which can be derived from its chemical structure.
When it comes to the melting point, the melting point is about -15 ° C, and the boiling point is roughly between 195-197 ° C. This boiling point characteristic allows its state to change accordingly under specific temperature conditions. The temperature gradually decreases, to below the melting point, the substance will change from liquid to solid; when the temperature rises, it will change from liquid to gaseous when it reaches the boiling point, which is the law of its phase change.
The density of 5-bromo-2-methoxypyridine is about 1.498g/mL, which is heavier than water. If mixed with water, it will sink to the bottom of the water, which is due to the difference in density.
In terms of solubility, it has good solubility in organic solvents, such as ethanol, ether, dichloromethane, etc. The molecular structure of organic solvents is compatible with 5-bromo-2-methoxypyridine and can be compatible with each other through intermolecular forces. In water, its solubility is poor, because there are fewer hydrophilic groups in the molecular structure, and the hydrophobic part accounts for a large proportion, so it is difficult to dissolve in water.
In addition, 5-bromo-2-methoxypyridine has a certain volatility, which will slowly evaporate into the air in an open environment. This volatility is related to the magnitude of the intermolecular force, which is weak, making it easy for its molecules to break free and escape into the gas phase.
In summary, the physical properties of 5-bromo-2-methoxypyridine, such as its properties, melting point, density, solubility, and volatility, are determined by its molecular structure, and these properties play a key role in organic synthesis and related applications.

There are several common methods for the synthesis of 5-bromo-2-methoxypyridine.
First, 2-methoxypyridine is used as the starting material and can be obtained by bromination reaction. Usually in a suitable solvent, such as dichloromethane and other inert solvents, a brominating agent, such as N-bromosuccinimide (NBS), is added, and the reaction is carried out in the presence of an initiator. The initiator can be selected from benzoyl peroxide or the like. Under heating or lighting conditions, NBS generates bromine radicals, attacking the 5-position of 2-methoxypyridine, and undergoing radical substitution reactions to obtain 5-bromo-2-methoxypyridine. The reaction conditions of this method are relatively mild and the selectivity is acceptable, but attention should be paid to controlling the reaction temperature and reagent dosage to avoid excessive bromination.
Second, start from 2-hydroxypyridine. First, 2-hydroxypyridine is methoxylated, and iodomethane or dimethyl sulfate are used as methylation reagents. Under the action of a base (such as potassium carbonate), the hydroxyl group is converted to methoxy to obtain 2-methoxypyridine, and then the target product is prepared according to the above bromination method. This route has a little more steps, but the raw material 2-hydroxypyridine is relatively easy to obtain.
Third, through palladium-catalyzed cross-coupling reaction. For example, 2-methoxy-5-halo-pyridine (such as 5-chloro-2-methoxy-pyridine) and brominating reagents (such as zinc bromide, etc.) react under the combined action of palladium catalysts (such as tetra (triphenylphosphine) palladium, etc.), ligands and bases. This method has stricter conditions and requires higher reaction equipment and operation, but it can achieve functionalization at specific locations, and is widely used in some syntheses that require high purity and selectivity.
The above synthesis methods have their own advantages and disadvantages. In practical application, it is necessary to comprehensively consider various factors such as raw material availability, cost, product purity, etc., and choose an appropriate method.

5-Bromo-2-methoxypyridine is also an organic compound. It has a wide range of uses and plays a significant role in the field of pharmaceutical synthesis. It can be used as a key intermediate for the preparation of various drugs. For example, in the synthesis process of some antibacterial drugs, it can participate in the construction of drug active structures, and through a series of chemical reactions, it can be coupled with other compounds to endow drugs with specific antibacterial effects.
In the field of pesticide creation, 5-bromo-2-methoxypyridine also has important value. It can be used as a raw material for the synthesis of new pesticides. By chemical modification, pesticide molecules with high insecticidal, bactericidal or herbicidal activities can be constructed. Due to its structural properties, it helps to enhance the affinity and specificity of pesticides to target organisms and enhance their efficacy.
In addition, in the field of materials science, it may be used to synthesize functional materials. By ingeniously designing the reaction path, it can be polymerized with other organic or inorganic monomers, giving the material unique photoelectric properties. For example, it is applied to the research and development of organic Light Emitting Diode (OLED) materials or semiconductor materials, contributing to the progress of materials science. In short, 5-bromo-2-methoxypyridine plays an indispensable role in many fields such as medicine, pesticides, and materials due to its own structure and chemical activity, promoting the development of related industries.

5-Bromo-2-methoxypyridine is an important raw material for organic synthesis. During storage and transportation, many matters need to be paid attention to.
When storing, the first environment. It must be placed in a cool, dry and well-ventilated place. This is because the substance encounters moisture, heat, or deterioration, which affects its quality. And it must be kept away from fire and heat sources to prevent the risk of fire. Cover it or be flammable, in case of open flame or hot topic, it may cause burning disaster.
In addition, storage containers should also be carefully selected. A sealed container should be used to prevent it from evaporating and to avoid contact with air and moisture. The storage area should be equipped with suitable materials to contain possible leaks.
As for transportation, it should not be neglected. Before transportation, make sure that the container is well sealed and safely loaded. During transportation, be sure to prevent exposure to the sun, rain, and high temperature. When handling, it should be handled lightly and lightly, and must not be operated brutally to avoid damage to the container and leakage of materials.
If the transportation vehicle transports such chemicals, the vehicle should be equipped with the corresponding variety and quantity of fire fighting equipment and leakage emergency treatment equipment. During transportation, the driver and escort personnel should pay close attention to the condition of the goods, and if there is any abnormality, they should dispose of it quickly. In this way, 5-bromo-2-methoxypyridine should be kept safe during storage and transportation.

5-Bromo-2-methoxypyridine, the price of the market is geometric, which is sincerely remembered by many industrial and technical people. However, it is not easy to determine the price of its market, and its price often changes due to various reasons.
First, the price of raw materials is also. The production of 5-bromo-2-methoxypyridine requires various raw materials. If the origin and output of raw materials change, or the price changes due to time, government orders, and merchants, the price of this pyridine will change accordingly.
Second, the complexity and cost of the process. In different workshops, the method of making this pyridine may be different. If the production process is complicated, it requires a variety of utensils, pharmaceuticals, and labor costs, the cost will be high, and the price will be high; if there is a clever method, it can save material and effort, and the price will be low.
Third, the supply and demand of the city are also. If at some time, the industry of using this pyridine is prosperous, and there are many applicants, but there are few producers, the price will rise; on the contrary, if the supply exceeds the demand, merchants want to sell their goods quickly, and the price may drop.
Fourth, the region varies. In the four places, the supply and demand are different, and the transshipment fee is also different. In Dayi, the capital of Tongdu, merchants converge, goods are easy to circulate, and the price is flat; in remote places, transshipment is difficult, costs increase, and prices are high.
Looking at past examples, the price of this pyridine is between hundreds and thousands of yuan per kilogram. However, this is only an approximate number, and the actual price should be subject to the current market conditions, the quality of the goods, and the number of buyers. To know the exact price, you need to consult the city of chemical materials and various suppliers, and observe their situation in detail before you can get a near-real price.