5-Bromo-2-Methoxy-6-Methylpyridine

5-Bromo-2-methoxy-6-methylpyridine is widely used in the field of organic synthesis. It is often used as a key intermediate and is involved in the preparation of many organic compounds.
In the process of pharmaceutical chemistry, this compound is particularly important. Due to its structural properties, it can participate in the construction of a variety of drug molecules. For example, when developing new antibacterial drugs, 5-bromo-2-methoxy-6-methylpyridine can be used as the starting material, and other active groups can be introduced through a series of chemical transformations to obtain molecules with specific antibacterial activities. In this process, the bromine, methoxy and methyl groups of the pyridine derivative can be substituted and added with other reagents according to the chemical reaction mechanism to gradually build the framework of drug molecules, thereby optimizing the activity, selectivity and pharmacokinetic properties of the drug.
In the field of materials science, 5-bromo-2-methoxy-6-methylpyridine has also emerged. It can be used to prepare functional organic materials such as optoelectronic materials. Its molecular structure can be rationally designed and modified to impart specific photoelectric properties to the material. For example, by connecting to the conjugated system, the electron transport and optical absorption properties of the material can be regulated, providing the possibility for the preparation of high-efficiency organic Light Emitting Diode (OLED) or organic solar cell materials. Its methoxy and methyl groups can affect the solubility, crystallinity and intermolecular interactions of molecules, and have a significant impact on the morphology and properties of materials.
In pesticide chemistry, 5-bromo-2-methoxy-6-methylpyridine also has a place. It can be used as an important building block for the synthesis of new pesticide active ingredients. Through chemical synthesis, it is converted into compounds with insecticidal, bactericidal or herbicidal activities. Using the active checking point in its structure, combined with other functional groups containing phosphorus and nitrogen, pesticide products with unique mechanism of action and high-efficiency biological activity are created, which can help agricultural pest control and ensure the yield and quality of crops.

The synthesis method of 5-bromo-2-methoxy-6-methylpyridine has existed in ancient times, and is described in detail below.
First, the corresponding pyridine derivative can be prepared by multi-step reactions such as halogenation, methoxylation and methylation. The starting material is selected as a suitable pyridine compound, and the halogenation reaction is carried out first. This step requires careful selection of halogenating reagents and reaction conditions. If a brominating reagent is used, under the presence of a suitable temperature and catalyst, a specific position of the pyridine ring is brominated, and bromine atoms are precisely introduced.
Then methoxylation is carried out. A suitable methoxylation reagent can be selected. Under the action of an alkaline environment or a specific catalyst, the methoxy group can be replaced by the corresponding position atom or group to achieve the access of the methoxy group.
Finally, the methylation step is carried out. Using methylation reagents, under appropriate reaction conditions, methyl is successfully introduced at the designated position of the pyridine ring to obtain 5-bromo-2-methoxy-6-methylpyridine.
Second, other nitrogen-containing heterocyclic compounds are also used as starting materials, and the synthesis of the target product is achieved through a series of rearrangement and substitution reactions. This path requires a deep understanding of the reaction mechanism and clever design of the reaction process. First, the initial nitrogen-containing heterocyclic compound undergoes a specific rearrangement, changes the molecular structure and activity check point, and then carries out the substitution reaction in an orderly manner, gradually introducing bromine, methoxy group and methyl group, and finally obtains the required 5-bromo-2-methoxy-6-methylpyridine.
These two synthesis methods have their own advantages and disadvantages, and need to be carefully selected according to the actual situation, such as the availability of raw materials, the ease of control of reaction conditions, the requirements of yield and purity.

5-Bromo-2-methoxy-6-methylpyridine is a kind of organic compound. It has unique physical properties, which are described below.
Looking at its appearance, under normal temperature and pressure, it often appears as a colorless to pale yellow liquid, such as a clear liquid, shimmering with light light. Its color is light, pure and free of variegated colors, like the clarity of autumn water.
As for the boiling point, it is about a certain temperature range. When the external pressure is at standard atmospheric pressure, its boiling point can reach a specific value, which depends on the strength of the intermolecular force. The intermolecular force is like a rope, which makes the molecules come together, and the boiling point is the energy required to break this binding. The melting point of
is also an important physical property. At a specific low temperature, the compound gradually solidifies from the liquid state and enters the solid state. The value of the melting point is similar to the boundary of cold and heat, which defines the form of the substance.
In terms of solubility, it can be quite soluble in organic solvents, such as ethanol and ether. Just like fish entering water, they are free to dissolve. This is because the molecular structure and organic solvent are in agreement, and the interaction between the two promotes the state of dissolution. However, in water, its solubility is limited, because the difference between the polarity of water and the structure of the compound makes it difficult to closely dissolve. The density of
is also one of its characteristics. Compared with water, its density is different. This density value represents the mass of the substance per unit volume and reflects the density of the molecular arrangement.
The physical properties of 5-bromo-2-methoxy-6-methylpyridine are determined by its molecular structure. The structure is like a blueprint, planning the appearance of physical properties, and various physical properties play an important role in organic synthesis, chemical research and other fields, affecting the process and results of reactions.

5-Bromo-2-methoxy-6-methylpyridine, this is an organic compound. Its chemical properties are unique, let me explain in detail.
First of all, its structural characteristics, on the pyridine ring of this compound, there are bromine atoms at the 5th position, methoxy groups at the 2nd position, and methyl groups at the 6th position. This structure gives it special chemical activity. Bromine atoms have high electronegativity, which changes the distribution of electron clouds in the pyridine ring, making this part more prone to nucleophilic substitution reactions. Nucleophilic reagents can attack the carbon attached to the bromine atom, substituting bromine, and then deriving a variety of new compounds, which is of great significance in the field of organic synthesis.
Looking at methoxy, which is the power supply group, can increase the electron cloud density of the pyridine ring, and has an impact on the electrophilic substitution reaction of the pyridine ring. Usually, electrophilic substitution is more likely to occur in the adjacent and para-sites, but due to the interaction of each substituent in the molecule, the specific reaction check point and activity depend on the actual reaction conditions.
The 6-position methyl group has relatively little effect on the electron cloud of the pyridine ring, but it will affect the proximity of the reaction reagent to the pyridine ring due to steric hindrance, which has an effect on some reaction selectivity. For example, in some reactions involving the space around the pyridine ring, the spatial hindrance of the methyl group will determine whether the reaction can occur or the configuration of the
In terms of physical properties, this compound has a certain polarity due to its polar group methoxy group, and its solubility may vary in common organic solvents. Generally, it is more soluble in polar organic solvents such as ethanol and acetone than in non-polar solvents such as n-hexane.
The chemical properties of 5-bromo-2-methoxy-6-methylpyridine are caused by the synergistic action of various groups in its structure. It may have potential applications in organic synthesis, medicinal chemistry and other fields, and can be used as a key intermediate to participate in the preparation of many compounds.

5-Bromo-2-methoxy-6-methylpyridine is in the market, and its price range is difficult to determine. The price of this compound often varies due to many factors.
First, the amount has a great impact. If you want a small amount, such as for scientific research experiments, you can buy it from a chemical reagent supplier, and the cost is high. Because the reagent needs to go through complicated processes such as purification, packaging, and quality inspection, the cost is relatively high, and the price can range from tens to hundreds of yuan per gram.
Second, the purity is related to the price. For high purity, the preparation is difficult, the required process is complicated, and the price is high. If it is used in high-end pharmaceutical research and development, the purity is extremely high, or more than 100 yuan per gram. And those with slightly lower industrial-grade purity may have lower prices, but they are also different due to market supply and demand.
Third, the trend of supply and demand affects the price. If the market demand increases sharply at a certain time, if a pharmaceutical company develops new drugs to increase its demand sharply, but the supply is limited, the price will rise; conversely, if the supply exceeds demand, the price may decline.
Fourth, the source of preparation also has an impact. The cost of natural extraction or complex synthesis routes is different, and the price is also different. Prepared by synthetic methods, if the raw materials are easy to obtain and the process is simple, the price may be relatively easy; if the raw materials are rare and the synthesis steps are complicated, the price will be high.
Therefore, if you want to know the exact price, you should consult the supplier in detail depending on the specific purchase quantity, purity requirements and current market conditions.