5-BROMO-2-METHOXY-4-METHYLPYRIDINE

5-Bromo-2-methoxy-4-methylpyridine is an organic compound with a wide range of uses.
In the field of organic synthesis, it is often used as a key intermediate. Due to the structure of bromine atoms, methoxy groups and methylpyridine in the molecule, it has unique reactivity. Bromine atoms can participate in many nucleophilic substitution reactions, allowing chemists to introduce various functional groups to build more complex organic molecules. For example, when building a new drug molecular structure, through nucleophilic substitution, bromine atoms are replaced by other groups with specific biological activities, and then compounds with novel pharmacological properties are developed.
In the field of medicinal chemistry, or conduct in-depth research on them to explore potential biological activities. Pyridine compounds play an important role in drug development, and many drug molecules contain pyridine structural units. The special substituents of 5-bromo-2-methoxy-4-methylpyridine may endow it with specific biological activities, such as antibacterial, anti-inflammatory, and anti-tumor. Scientists can modify its structure and screen its activity to discover new lead compounds and lay the foundation for the creation of new drugs.
In the field of materials science, it may also play a role. The properties of organic materials are closely related to the molecular structure, and the unique structure of the compound may make it exhibit useful properties in the preparation of specific materials. For example, in the field of organic optoelectronic materials, its structural properties may help to regulate the optoelectronic properties of materials, providing the possibility for the development of new optoelectronic materials.
In summary, 5-bromo-2-methoxy-4-methylpyridine has important application value and research potential in many fields such as organic synthesis, medicinal chemistry, and materials science due to its unique structure.

5-Bromo-2-methoxy-4-methylpyridine is one of the organic compounds. Its physical properties are quite important and are involved in scientific research and chemical industry.
Looking at its properties, under normal temperature and pressure, it is mostly in a solid state. However, its specific appearance may vary slightly due to factors such as purity. The common color may be white to off-white powder, or crystalline. The melting point of this compound is within a certain range, but the exact value may vary slightly due to different measurement methods and instruments. Generally speaking, its melting point is between [X] ° C and [X] ° C. This property is quite useful in operations such as identification, separation and purification of substances.
Furthermore, its solubility is also a key property. In common organic solvents, such as ethanol, acetone, etc., 5-bromo-2-methoxy-4-methylpyridine exhibits a certain solubility. In ethanol, it can be moderately dissolved to form a uniform solution. This dissolution process may be affected by temperature. When the temperature rises, its solubility in ethanol may increase. In water, its solubility is relatively poor, and it is mostly insoluble. This is due to the characteristics of its molecular structure. The hydrophobic groups contained in the molecules make the interaction between them and water molecules weak.
In addition, the density of 5-bromo-2-methoxy-4-methylpyridine is also a specific value. Although its specific value needs to be accurately measured, it can be roughly known that its density is similar to that of common organic compounds. This density property is related to the measurement of materials and the ratio of reaction systems in chemical production.
Its volatility is relatively low, and it is not easy to evaporate into the air under conventional environments. This property reduces losses and safety risks caused by volatilization during storage and use.
Overall, the physical properties of 5-bromo-2-methoxy-4-methylpyridine, such as appearance, melting point, solubility, density, and volatility, are interrelated and meaningful, and are indispensable factors in many fields such as organic synthesis and drug development.

There are several common methods for synthesizing 5-bromo-2-methoxy-4-methylpyridine.
First, it can be started from the corresponding pyridine derivative. Using suitable 2-methoxy-4-methylpyridine as raw material, obtained by bromination reaction. In the reaction system, select suitable brominating reagents, such as bromine (Br ²), N-bromosuccinimide (NBS), etc. If bromine is used, it can be carried out in suitable solvents, such as dichloromethane and carbon tetrachloride. When reacting, it is necessary to pay attention to the control of the reaction temperature. Usually, the reaction is easier to control at low temperature, which can avoid the formation of polybrominated by-products. When using N-bromosuccinimide, it is often necessary to add an initiator, such as benzoyl peroxide, to initiate the reaction. This reaction condition is relatively mild and has good selectivity for substrates.
Second, the strategy of constructing a pyridine ring can be used. For example, a specific nitrogen-containing and carbonyl-containing compound is used to construct a pyridine ring through a multi-step reaction, and methoxy, methyl and bromine atoms are introduced at the same time. Suitable aldodes, ketones and ammonia or amine compounds can be condensed under specific conditions to form the prototype of the pyridine ring, and then the desired substituents can be gradually introduced through halogenation, methylation, methoxylation and other reactions. Although there are many steps in this method, the reaction sequence and conditions can be flexibly adjusted to obtain the target product.
Third, metal-catalyzed coupling reaction strategies can also be used. If there are pyridine derivatives containing some substituents, metal-catalyzed coupling reactions can be used, such as Suzuki coupling, Buchwald-Hartwig coupling, etc. Under the action of palladium, nickel and other metal catalysts, a coupling reaction occurs between bromo-containing pyridine derivatives and suitable methoxylating reagents and methylating reagents, so that methoxy and methyl are introduced to achieve the purpose of synthesizing 5-bromo-2-methoxy-4-methylpyridine. This method has high selectivity and the reaction conditions are relatively controllable.

5-Bromo-2-methoxy-4-methylpyridine is also an organic compound. When storing and transporting, pay attention to many matters.
The temperature and humidity of the first storage. This compound should be stored in a cool, dry place, away from high temperature and humidity. High temperature may cause its chemical properties to deteriorate, and humid gas can also induce reactions such as hydrolysis, which will damage its quality. If placed in a place with humidity exceeding 60%, or a temperature higher than 30 ° C, there is a risk of deterioration.
The second is anti-oxidation. Because of its certain chemical activity, it is easily oxidized by oxygen in the air. Therefore, when storing, it is advisable to use a sealed container to reduce contact with air. If the container is filled with inert gas such as nitrogen, it can effectively prevent its oxidation.
Furthermore, the storage place should be kept away from fire sources and oxidants. This compound may be flammable, but it is dangerous in case of fire sources; and when it encounters oxidants, it is easy to cause violent chemical reactions and cause safety accidents.
When transporting, the packaging must be sturdy. Packaging materials that can withstand a certain external impact must be used to prevent it from being damaged due to bumps and collisions during transportation. And the transportation vehicle should also be kept clean and free of other chemical residues that may react with it.
At the same time, the transportation personnel should be familiar with the characteristics of this compound and emergency treatment methods. If there is leakage on the way, it can be disposed of quickly and properly to avoid greater harm. In this way, the safety and quality of 5-bromo-2-methoxy-4-methylpyridine during storage and transportation are guaranteed.

What you are asking is the market price range of 5-bromo-2-methoxy-4-methylpyridine. However, the price of this compound often varies due to many factors, and it is difficult to hide it.
First, purity is the key factor. If its purity is extremely high, it is almost perfect, and it is suitable for high-end scientific research or special industrial processes, its price will be high. For high-purity things, it is difficult to prepare, and it requires exquisite craftsmanship and complicated processes, so the price is not cheap. On the contrary, if the purity is slightly lower, it is only suitable for general use, and the price should be much lower.
Second, market supply and demand also have a great impact. If there is a strong demand for this compound at a certain moment, but the supply is limited, just like the rain in a dry time, the merchant will take advantage of the situation to raise the price. On the contrary, if the supply is sufficient and the demand is few, the price will be reduced accordingly in order to get rid of it.
Third, the purchase quantity also affects the price. If you buy in large quantities, like wholesale, the merchant will make small profits but quick turnover, or give discounts, the unit price will be reduced. If you buy only in small quantities, like retail, the price will naturally be higher.
According to past market conditions and price patterns of similar compounds, 5-bromo-2-methoxy-4-methylpyridine, if the purity is around 95%, when purchased in small quantities, the price per gram may range from tens to hundreds of yuan. If purchased in large quantities, such as kilograms, the price per gram may be reduced to a few to ten yuan. However, this is only a rough guess. The real price still needs to be consulted with the chemical raw material supplier, subject to the actual quotation of that place at that time.