5-BROMO-2-METHOXY-4-METHYLPYRIDINE, 96+%

5-Bromo-2-methoxy-4-methylpyridine, with a purity of more than 96%, is commonly used in a wide range of applications. In the field of medicinal chemistry, it is often used as a key intermediate. For example, in the development of new antimalarial drugs, its unique chemical structure can participate in the construction of an active molecular skeleton, and other functional groups can be introduced through multi-step reactions to obtain specific pharmacological activities. In the synthesis of compounds with potential anti-tumor activity, it is also an important starting material. Complex molecular structures are built by organic synthesis methods, providing the possibility for the development of anti-cancer drugs.
In the field of materials science, or used in the preparation of organic optoelectronic materials. Due to its nitrogen-containing heterocycle, halogen atom, methoxy group, etc., the electronic cloud distribution and energy level structure of the material can be adjusted, and the photoelectric properties of the material can be improved. For example, when making organic Light Emitting Diode (OLED), it may improve the luminous efficiency and stability, and prepare high-efficiency luminescent layer materials.
also has important applications in the field of pesticide chemistry. It can be used as an intermediate for synthesizing new insecticides or fungicides. Through rational design and reaction, its structure is connected to biologically active groups, and high-efficiency, low-toxicity and environmentally friendly pesticide products can be developed to enhance the control effect of crop diseases and insect pests.

To prepare 5-bromo-2-methoxy-4-methylpyridine, there are various methods.
First, the corresponding pyridine derivative can be started. First, take a pyridine containing a suitable substituent, such as 4-methyl-2-methoxypyridine, and introduce bromine atoms through a bromination reaction. This bromination reaction can be initiated by heating or lighting in a suitable solvent, such as dichloromethane, with a brominating agent, such as N-bromosuccinimide (NBS), and in the presence of an initiator, such as benzoyl peroxide. Due to the characteristics of the electron cloud distribution of the pyridine ring, bromine atoms can be selectively introduced at the 5-position to obtain the target product.
Second, pyridine rings can also be constructed from raw materials. Start with suitable open-chain compounds, such as β-ketone esters and ammonia or amine compounds, and cyclize to form pyridine rings under appropriate conditions. First prepare a pyridine ring intermediate containing methoxy and methyl, and then go through the bromination step. During bromination, according to the above-mentioned similar bromination conditions, carefully select the reagents and reaction environment, so that bromine atoms can be precisely introduced into the 5-position to synthesize 5-bromo-2-methoxy-4-methylpyridine.
Furthermore, a metal-catalyzed coupling reaction can be used. A halogenated pyridine derivative is used to couple with an organometallic reagent containing methoxy and methyl, such as Grignard reagent or an organolithium reagent, under the action of a metal catalyst such as palladium catalyst. A suitable halogenated pyridine is prepared first, and then methoxy and methyl are introduced through a coupling reaction, or vice versa, methoxy and methyl are introduced first, and then halogenated to introduce bromine atoms, and the target product is obtained through a multi-step reaction. In the reaction, the reaction conditions, such as temperature, catalyst dosage, and reagent ratio, need to be strictly controlled to improve the reaction yield and selectivity.

Today there is 5-bromo-2-methoxy-4-methylpyridine with a purity of 96 +%. What is the market price? This question is related to the price of chemistry, just like the ancient business inquiry. In the world of "Tiangong Kaiwu", although there is no such fine chemical, there is no business principle.
To know the market price of this product, you need to look at many things. First, the source and flow of materials. If the raw material of this chemical is easy to obtain and widely available, it will be inexpensive; if the raw material is rare and difficult to obtain, it will be expensive. Second, the preparation is simple and simple. If the preparation method is simple, labor and effort are saved, the cost is reduced, and the price is also reduced; if the preparation process is cumbersome, time-consuming and expensive, the price will be high. Third, the supply and demand of the city. If there are many applicants, there are few suppliers, so-called rare things are expensive, and the price will rise; if the supply exceeds the demand, merchants will compete to sell, and the price will fall.
Looking at today's chemical market, this 5-bromo-2-methoxy-4-methylpyridine, or because of its use, is in high demand in specific industries. However, its preparation may require special methods and specialized equipment, resulting in high costs. And in the chemical industry, safety and environmental protection regulations are very strict, and the cost of compliance is also added to the selling price.
With today's common sense, the price of such high-purity chemicals per gram may be more than tens of yuan to hundreds of yuan due to the above reasons. However, the market is volatile, and the price moves with the trend. If you want to get an accurate price, you should consult the chemical material suppliers in detail and observe the recent trading conditions. Only then can you be sure. The merchants of ancient times must carefully observe the market conditions before setting the price.

5-Bromo-2-methoxy-4-methylpyridine, 96 +%, the Quality Standards are as follows:
Appearance should be colorless to light yellow liquid or crystalline, and it should be pure and free of visible impurities. This is the first characterization, which is related to its intuitive quality.
Content, which needs to reach more than 96%, this is the key indicator, which determines the amount of its active ingredients, and is related to its effectiveness in various reactions and applications. The determination method is often carried out by high-performance liquid chromatography (HPLC). Accurate content data are obtained through precise instruments and rigorous operation. < Br >
Melting point range is also an important consideration. Although the specific value may vary depending on different conditions, the melting point of a qualified 5-bromo-2-methoxy-4-methylpyridine should be within a specific and relatively stable range. To determine the melting point, the capillary method is commonly used to carefully observe the temperature range of the sample from solid to liquid to judge its purity and quality.
Moisture content should be maintained at a low level, generally not higher than a certain limit value, such as 0.5%. Excessive moisture, or affecting its chemical stability, may also interfere with the process of related chemical reactions. To determine moisture, the Karl Fischer method is often used, which is a good method for accurate determination of trace moisture content.
In terms of impurities, all kinds of impurities need to be strictly controlled. Such as the type and content of organic impurities, which need to be determined by precise analysis, and must not exceed the specified limit. Inorganic impurities should also not be ignored to ensure the purity and consistency of the product and meet the needs of various application scenarios.

5-Bromo-2-methoxy-4-methylpyridine, with a content of more than 96%. The storage conditions of this substance are crucial. It needs to be stored properly to keep its quality unchanged and its properties intact.
This product should be placed in a cool place, because the temperature is too high, which is easy to cause chemical reactions and damage its quality. In a cool place, the temperature is often relatively stable, which can reduce its changes due to heat. And it should be kept dry. Moisture can easily cause many adverse reactions, such as hydrolysis, to deteriorate the substance.
Furthermore, it needs to be stored in a well-ventilated place. Good ventilation can avoid the accumulation of harmful gases. If the air in the storage space is not smooth, once the substance evaporates a little, the gas accumulates, or there is a risk of safety, it may also affect its own properties.
At the same time, it should be stored separately from oxidizing agents, acids, alkalis and other substances. This is because of its active chemical properties. Contact with the above-mentioned various substances is very likely to cause severe chemical reactions, or cause serious consequences such as combustion and explosion.
The place where the substance is stored should be clearly marked, indicating the name, characteristics and storage precautions of the substance. In this way, it is convenient for access and management personnel to understand the situation, and correct methods can be followed during operation to prevent accidents. And it is necessary to regularly check its storage status to check whether the packaging is in good condition and whether there are any abnormal conditions such as leakage. If so, deal with it immediately to ensure the safety and stability of storage.