5-Bromo-2-(hydroxymethyl)pyridine

5-Bromo-2- (hydroxymethyl) pyridine, which has a wide range of uses. In the field of medicinal chemistry, it is a key intermediate. The unique structure of the Gein pyridine ring and the active groups of bromine atoms and hydroxymethyl groups can be used to construct complex drug molecular structures through many chemical reactions. For example, through substitution reactions, bromine atoms can be replaced by various functional groups, thereby deriving compounds with specific pharmacological activities, laying the foundation for the development of new drugs.
In the field of materials science, 5-bromo-2- (hydroxymethyl) pyridine also plays an important role. Because it contains active groups, it can participate in polymerization reactions to prepare functional polymer materials. Such materials may have unique optical and electrical properties, and have great application potential in optoelectronic devices, sensors and other fields.
In addition, in organic synthetic chemistry, it is often used as a starting material to synthesize complex organic compounds through multi-step reactions. With its activity check point, chemists can ingeniously design reaction routes to achieve efficient synthesis of target products and help the development of organic synthetic chemistry. In short, 5-bromo-2- (hydroxymethyl) pyridine plays an indispensable role in many fields, promoting the progress and development of related disciplines.

The method of synthesizing 5-bromo-2- (hydroxymethyl) pyridine has been around for a long time, and it has been evolving over the years. In the past, the method usually started from the starting material of pyridine and went through several steps of reaction to achieve the purpose of synthesis.
One method is to introduce bromine atoms at the 5th position under appropriate conditions based on pyridine. This step often requires delicate reaction conditions to ensure that the bromine atom falls precisely at the 5th position. Or use a brominating reagent, assisted by a catalyst, to carry out a bromination reaction. After 5-bromopyridine is obtained, hydroxymethyl is introduced at the 2nd position. This step can be achieved by the reaction of halogenated hydrocarbons and hydroxymethyl-containing reagents through mechanisms such as nucleophilic substitution. However, in this process, the control of reaction conditions is extremely critical. If there is a slight difference in temperature, solvent, and reactant ratio, side reactions may occur and the yield will decrease.
There is another method, using other nitrogen-containing heterocyclic compounds as starting materials, through a series of reactions such as cyclization and functional group transformation, the structure of 5-bromo-2- (hydroxymethyl) pyridine is gradually constructed. Although this approach is slightly complicated, if it is well designed, it can effectively avoid some side reactions and improve the purity and yield of the product. And with the advance of science and technology, new catalytic systems and reaction media continue to emerge, providing new opportunities for the synthesis of this compound. For example, the application of new metal catalysts can make the reaction conditions milder and better selectivity; the use of green reaction media is also in line with the current trend of environmental protection, making the synthesis process more sustainable. All of these are effective paths for the synthesis of 5-bromo-2- (hydroxymethyl) pyridine, but each has its own advantages and disadvantages, and needs to be selected according to the actual situation.

5-Bromo-2- (hydroxymethyl) pyridine, this substance is an organic compound. Looking at its physical properties, at room temperature, it often appears solid, with a color or nearly white, powdery and fine texture.
The melting point is about a specific numerical range. This temperature is the critical point for the substance to melt from a solid state to a liquid state. The characteristics of the melting point play a key role in the identification and purification of this substance. In organic solvents, its solubility shows a certain law. In common organic solvents, such as ethanol and dichloromethane, it can show a good state of dissolution and can fuse with the solvent to form a uniform solution. However, in water, the solubility is different, because its molecular structure contains hydrophilic hydroxymethyl groups, as well as hydrophobic pyridine rings and bromine atoms, so the degree of solubility in water is limited and only slightly soluble.
In addition, the density of this substance is higher than that of water, and if placed in water, it will sink to the bottom. Its stability is acceptable under normal conditions. However, when encountering hot topics, open flames or strong oxidants, there may be reactions. Therefore, when storing and using, it is necessary to pay attention to environmental factors and stay away from such dangerous conditions to prevent accidents and ensure safe operation.

5-Bromo-2- (hydroxymethyl) pyridine, this material has special properties and is related to chemistry. Its color state, under normal conditions, or white to off-white crystalline powder, looks fine and looks like frost and snow.
As for the melting point, the melting point is about a specific range, which is caused by the force between molecules. In its molecular structure, the bromine atom interacts with the hydroxymethyl and pyridine rings, resulting in a fixed melting point. When heated to a certain temperature, the lattice vibration intensifies, the molecules break free and melt into a liquid state. The boiling point is also determined by the complex interaction between molecules. To make it boil, energy needs to be supplied to break the attractive force between molecules. < Br >
In terms of solubility, it is quite soluble in organic solvents such as ethanol and acetone. Due to the principle of "similar miscibility", its molecules have a certain polarity and are similar to the polarity of organic solvents, so they are mutually soluble. However, in water, although there are hydroxymethyl groups that can form hydrogen bonds with water, the hydrophobicity of bromine atoms and pyridine rings is disturbed, so the solubility is limited.
In terms of chemical activity, bromine atoms are active and prone to substitution reactions. Nucleophiles attack, bromine can be replaced, and new groups can be introduced to expand the use of substances. Hydroxymethyl groups are also active and can be oxidized to aldehyde or carboxyl groups, or participate in esterification reactions to form esters with acids. The pyridine ring is alkaline and can form salts with acids, and the distribution of electron clouds on the ring is different, and it is prone to electrophilic substitution at specific positions.
Because of its many special chemical properties, it is widely used in the field of organic synthesis. It is an important building block for building complex organic molecules, and also plays an important role in pharmaceutical chemistry, materials science, etc. It can be used as raw materials to make new drugs and functional materials, with broad prospects.

I haven't heard the exact price of 5 - Bromo - 2 - (hydroxymethyl) pyridine on the market. However, if you want to know its price, you can ask for it from all ends.
First, consult the suppliers of chemical raw materials. Today, there are many specialized merchants in the sale of chemical materials. They have a wide range of supply and are familiar with the market of various materials. Call or visit their stores to inquire about the price of this compound in detail, and you can get a recent quotation. Different merchants have different quotations due to different supply, cost and profit considerations. Ask a few more to understand the approximate price range.
Second, explore on the online chemical product trading platform. Nowadays, e-commerce is popular, and many chemical products are sold on online platforms. Log in to such professional platforms to search for the compound, and the quotations of merchants listed on the platform can be used for reference. However, it should be noted that online prices may change due to factors such as promotions and bulk purchase discounts, and there are price differences between different platforms.
Third, refer to the procurement information of academic research institutions. Scientific research institutes often need such chemical reagents, and their procurement records may reveal price clues. However, such information is not easy to obtain, or you need to communicate with relevant institutions or consult their public procurement reports to have a chance to know.
Overall, in order to obtain the price range of 5-Bromo-2 - (hydroxymethyl) pyridine, you must search for information widely and compare the data of merchants, platforms and institutions in order to have a more accurate understanding of its price range. However, it is difficult to determine the exact price range at the moment, because the market is constantly changing, and prices are influenced by a variety of factors.