5-Bromo-2-hydroxy-4-methylpyridine

5-Bromo-2-hydroxy-4-methylpyridine, this is an organic compound. It has unique chemical properties, let me talk about them one by one.
From the structural point of view, its pyridine ring is connected with bromine atoms, hydroxyl groups and methyl groups. Bromine atoms have certain electronegativity, which can change the polarity of molecules, and due to the large atomic radius of bromine, it also has an impact on the steric hindrance. In chemical reactions, bromine atoms are active and can participate in nucleophilic substitution reactions. For example, under suitable conditions, nucleophilic test agents can attack carbon atoms attached to bromine, causing bromine atoms to leave, and then form new compounds.
Hydroxy groups are strongly polar groups and can participate in the formation of hydrogen bonds. This property makes 5-bromo-2-hydroxy-4-methylpyridine have specific solubility in some solvents, and can also affect its intermolecular interactions. Hydroxyl groups can also undergo many reactions, such as esterification. Under the action of acid in the catalyst, the hydrogen atom in the hydroxyl group is substituted by the acyl group to form ester compounds.
Methyl as the power supply group will affect the electron cloud density distribution of the pyridine ring. It can increase the relative electron cloud density of the pyridine ring adjacent and para-position, which affects the activity and positional selectivity of the electrophilic substitution reaction. When the electrophilic reagent attacks, the adjacent and para-position of the methyl group are more likely to react. Overall, 5-bromo-2-hydroxy-4-methylpyridine is rich in chemical properties, and its substituents interact with each other, which makes it have many potential applications in the field of organic synthesis. It can be used as a key intermediate for the synthesis of various complex organic compounds.

5-Bromo-2-hydroxy-4-methylpyridine is one of the organic compounds. It has a wide range of uses and has shown its important value in many fields.
In the field of pharmaceutical chemistry, this compound is often a key intermediate. It can be converted into drug molecules with unique physiological activities through specific chemical reactions. Or participate in the construction of the core structure of the drug, which has a profound impact on the pharmacological action, pharmacodynamics and pharmacokinetic properties of the drug. Due to the strict requirements for the structural accuracy and characteristics of compounds in drug development, the special chemical structure of 5-bromo-2-hydroxy-4-methylpyridine can just meet the needs of specific drug synthesis routes and lay the foundation for the creation of new drugs.
In the field of materials science, it also plays an important role. It can be used as a starting material for the synthesis of functional materials. For example, when synthesizing materials with specific optical, electrical or thermal properties, by modifying and derivatizing their structures, other functional groups are introduced, thereby giving the material unique properties. Or it can be used to prepare organic Light Emitting Diode (OLED) materials, which can achieve high-efficiency luminescence properties by virtue of their structural properties, and have potential applications in the field of display technology.
Furthermore, in the field of organic synthetic chemistry, 5-bromo-2-hydroxy-4-methylpyridine has become an extremely active reaction substrate due to its presence of bromine atoms, hydroxyl groups and methyl groups. It can participate in a variety of classical organic reactions, such as nucleophilic substitution reactions, coupling reactions, etc. Through these reactions, chemists can construct complex and diverse organic molecular structures, providing rich strategies and means for the development of organic synthetic chemistry, and assisting in the synthesis of more novel and practical organic compounds.

There are many ways to synthesize 5-bromo-2-hydroxy-4-methylpyridine. One method can also be started from 4-methylpyridine. Shilling 4-methylpyridine reacts with appropriate brominating reagents, such as bromine (Br ²), under specific reaction conditions. This reaction may need to be carried out in appropriate solvents, such as chloroform, dichloromethane and other halogenated hydrocarbon solvents, and may require the addition of catalysts, such as iron powder (Fe) or iron tribromide (FeBr ²). During the bromination reaction, bromine atoms will selectively replace hydrogen atoms at specific positions on the pyridine ring to obtain 5-bromo-4-methylpyridine.
Then, 5-bromo-4-methylpyridine is hydroxylated. This step can be reacted under high temperature and pressure by reacting with strong basic reagents, such as sodium hydroxide (NaOH) or concentrated solutions of potassium hydroxide (KOH). Hydroxyl groups (OH) in the alkali solution will replace bromine atoms, thereby introducing hydroxyl groups, resulting in 5-bromo-2-hydroxy-4-methylpyridine.
Another method can be started from suitable pyridine derivatives. For example, 2-methoxy-4-methylpyridine is used as the starting material. First, bromination is carried out with a brominating reagent. Also under suitable solvent and catalytic conditions, the bromine atom is substituted at the 5-position of the pyridine ring to generate 5-bromo-2-methoxy-4-methylpyridine. Then, the methoxy group is demethylated. The commonly used reagents are hydrobromic acid (HBr) or boron tribromide (BBr). Under appropriate reaction temperature and time control, the methoxy group is replaced by a hydroxyl group, and the target product is 5-bromo-2-hydroxy-4-methylpyridine.
Furthermore, organometallic reagents can also be used to participate in the reaction path. For example, the organolithium reagent or Grignard reagent containing pyridine structure is first prepared, and then it is nucleophilic substitution or addition reaction with suitable bromine and hydroxyl reagents. After subsequent treatment and purification, it is also expected to obtain 5-bromo-2-hydroxy-4-methylpyridine. However, this path requires high control of the reaction conditions, and the preparation and use of reagents need to be handled with caution.

I look at the "5 - Bromo - 2 - hydroxy - 4 - methylpyridine" you are inquiring about. The market price of this product is not easy to know. Due to the complex market conditions, many factors can affect its price.
First, the price of raw materials has a great impact. If the starting materials required for the preparation of this compound are scarce or expensive, the final price will also rise. The cover raw materials are the foundation of production, and the foundation is unstable, and price fluctuations are inevitable.
Second, the preparation method is also crucial. The delicate and efficient synthesis method can reduce costs and make the price accessible to the people; however, if the process is cumbersome and time-consuming, the price will be high.
Third, the balance between market supply and demand is also the main reason. If the demand for this product is strong and the supply is limited, the merchant will raise the price in pursuit of profit; on the contrary, if the supply exceeds the demand, the price may be reduced for promotional sales.
Fourth, the difference in region also causes the price to be different. In different places, due to transportation costs, tax differences, etc., the selling price may be high or low.
As for the example of "Tiangong Kaiwu", the book describes all kinds of crafts, but it is very different from today. In today's chemical market, technology is constantly changing, and trade is globalized, which is not comparable to ancient times. Although it is difficult to say exactly the price of "5 - Bromo - 2 - hydroxy - 4 - methylpyridine", if you want to know the details, you should consult chemical raw material suppliers, traders, or professional market survey reports to get a more accurate price.

5-Bromo-2-hydroxy-4-methylpyridine is an organic compound. When storing and transporting, the following matters should be paid attention to:
First, the storage environment must be dry and cool. This compound is susceptible to humid air. If placed in a humid place, reactions such as hydrolysis may occur, causing it to deteriorate. Therefore, it should be stored in a dry and ventilated warehouse, away from water sources and places where water vapor may invade.
Second, it needs to be stored away from light. Some chemical bonds in 5-bromo-2-hydroxy-4-methylpyridine are unstable under light conditions, and light or luminescent chemical reactions cause structural changes. Therefore, it should be stored in a brown bottle or an opaque container, and stored in a place without direct light.
Third, this compound may have certain toxicity and irritation. When storing, avoid direct contact with the human body, and the operator should wear appropriate protective equipment, such as gloves, goggles and masks. In case of accidental contact, rinse with plenty of water immediately, and seek medical treatment according to the specific situation.
Fourth, when transporting, ensure that the packaging is intact. The packaging material should be able to resist vibration, collision and friction to prevent the leakage of the compound due to the rupture of the container. At the same time, the transportation vehicle should also be kept dry, cool, and away from fire and heat sources.
Fifth, 5-bromo-2-hydroxy-4-methylpyridine chemicals should be transported and stored in accordance with relevant regulations and standards. Whether it is the choice of storage sites or the regulation of transportation processes, we must act in strict accordance with the law to ensure the safety of personnel and the environment from pollution.